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| 1 | Beneficial effects of adenosine triphosphate-sensitive K^+ channel opener on liver ischemia/reperfusion injury显示文摘AIM:To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury.METHODS:Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation.They were divided into 3 groups:Control Group,rats submitted to liver manipulation,Saline Group,rats received saline,and Diazoxide Group,rats received intravenous injection diazoxide(3.5 mg/kg) 15 min before liver reperfusion.4 h and 24 h after reperfusion,blood was collected for determination of aspartate transaminase(AST),alanine transaminase(ALT),tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),nitrite/nitrate,creatinine and tumor growth factor-β1(TGF-β1).Liver tissues were assembled for mitochondrial oxidation and phosphorylation,malondialdehyde(MDA) content,and histologic analysis.Pulmonary vascular permeability and myeloperoxidase(MPO) were also determined.RESULTS:Four hours after reperfusion the diazoxide group presented with significant reduction of AST(2009 ± 257 U/L vs 3523 ± 424 U/L,P = 0.005); ALT(1794 ± 295 U/L vs 3316 ± 413 U/L,P = 0.005); TNF-α(17 ± 9 pg/mL vs 152 ± 43 pg/mL,P = 0.013; IL-6(62 ± 18 pg/mL vs 281 ± 92 pg/mL); IL-10(40 ± 9 pg/mL vs 78 ± 10 pg/mL P = 0.03),and nitrite/nitrate(3.8 ± 0.9 μmol/L vs 10.2 ± 2.4 μmol/L,P = 0.025) when compared to the saline group.A significant reduction in liver mitochondrial dysfunction was observed in the diazoxide group compared to the saline group(P < 0.05).No differences in liver MDA content,serum creatinine,pulmonary vascular permeability and MPO activity were observed between groups.Twenty four hours after reperfusion the diazoxide group showed a reduction of AST(495 ± 78 U/L vs 978 ± 192 U/L,P = 0.032); ALT(335 ± 59 U/L vs 742 ± 182 U/L,P = 0.048),and TGF-β1(11 ± 1 ng/mL vs 17 ± 0.5 ng/mL,P = 0.004) serum levels when compared to the saline group.The control group did not present alterations when compared to the diazoxide and saline groups.CONCLUSION:Diazoxide maintains liver mitochondrial function,increases liver tolerance to ischemia/reperfusion injury,and reduces the systemic inflammatory response.These effects require further evaluation for using in a clinical setting. | Mateus Antunes Nogueira Ana Maria Mendona Coelho Sandra Nassa Sampietre Rosely Antunes Patzina Fabiano Pinheiro da Silva Luiz Augusto Carneiro D'Albuquerque Marcel Cerqueira Cesar Machado | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 2 | Pyrolysis kinetics of lignocellulosic materials three independent reaction model 显示文摘 | Orfao J Antunes F J A Figueiredo J L | 1999 | Fuel1999，78，3： | 1 |
| 3 | Microencapsulated chitosan-dextran sulfate nanoparticles for controlled delivery of bioactive molecules and cells in bone regeneration显示文摘 | Valente J F A Gaspar V M Antunes B P | 2013 | Polymer2013，54，： | 1 |
| 4 | Characterization of traditional and exotic apple varieties from Portugal part 1-nutritional, phytochemical and sensory evaluation显示文摘 | FELICIANO R P ANTUNES C RAMOS A | 2010 | Journal of Functional Foods2010，2，1： | 1 |
| 5 | Eevelopment and characterization of a cheese analogue containing aqueous soya extract (soya mill), whey and cow milk显示文摘 | Pereirag V Antunes L A F Dos Santos Ferreira da Silva R S | 1992 | Arquivo de Biologiay Tecnica1992，35，： | 1 |
| 6 | Alkaline PF Resins Linear Ex- tension by Urea Condensation with Hydroxybenzylalcohol Groups 显示文摘 | Pizzi A Stephanou A Antunes I | 1993 | Journal of Applied Polymer Science1993，50，12： | 1 |
| 7 | Comparison of a R744 cascade refrigeration system with R404A and R22 conventional systems for su- permarkets 显示文摘 | DA SILVA A FILHO E P B ANTUNES A H P | 2012 | Applied Thermal Engineering2012，41，： | 1 |
| 8 | Systemic cytokine levels in community-acquired pneumonia and their association with disease severity 显示文摘 | Antunes G Evans S A Lordan J L | 2002 | Eur Respir J2002，20，4： | 1 |
| 9 | Endometrial polyps in preand postmenopausal women: factors associated with malignancy显示文摘 | Antunes A Costa-Paiva L Arthuso M | 2007 | Maturitas2007，57，4： | 1 |
| 10 | Chemical, physi- cal, microstructural and sensory properties of set fat-free yogurts stabi- lized with whey protein concentrate 显示文摘 | ANTUNES A E C ANTUNES A J CARDELLO H | 2004 | Milchwissenschaft2004，59，34： | 1 |
| 11 | Bi- axial optical aceelerometer and high-angle inclinome- ter with temperature and cross-axis insensitivity显示文摘 | Antunes P F C Marques C A Varum H | 2012 | IEEE Sensors Journal2012，12，7： | 1 |
| 12 | TSH-stimulating hormone stimulates lipolysis in adipocytes in culture and raises serum free fatty acid levels in vivo显示文摘 | Gagnon A Antunes TT Ly T | 2010 | Metabolism2010，59，4： | 1 |
| 13 | Morphology development and phase inversion during dynamic vuleanisation of EPDM/PP blends 显示文摘 | ANTUNES C F MACHADO A V VAN DU1N M | 2011 | European Polymer Journal2011，47，7： | 1 |
| 14 | Early result on a prospective randomized trail : robotic-assisted laparoseopic prostatectomy (RALP) versus retropubic radical prostatectomy (RRP) study显示文摘 | PASSEROTTI C C ANTUNES A A OKANO M T R | 2011 | J Urol2011，185，41： | 1 |
| 15 | Catalytic cyclodehydration of xylose to furfural in the presence of zeolite H-Beta and a micro/ mesoporous Beta/TUD-1 composite material 显示文摘 | Lima S Antunes M Femandes A | 2010 | Applied Catalysis A General2010，388，12： | 1 |
| 16 | A study on the mechanical behaviour of WC/Co hardmetals显示文摘 | FERREIRA J A M P1NA AMARAL M A ANTUNES F V COSTA J D M | 2009 | International Journal of Refractory Metals & Hard Materials2009，27，： | 1 |
| 17 | Bone marrow-derived mononuclear cell vs mesenchymal stro- real cells in experimental allergic asthma 显示文摘 | Abreu Soraia C Antunes Mariana A Castro Julia C | 2013 | Respiratory physiology2013，187，2： | 1 |
| 18 | Morphologic and molecular features of hepatocellular adenoma with gadoxetic acid-enhanced MR imaging显示文摘 | Ba-Ssalamah A Antunes C Feier D | 2015 | Radiology2015，277，5： | 1 |
| 19 | Interleukin-6 release from human abdominal adipose ceils is regulated by thyroid stimulating hor- mone: effect of adipocyte differentiation and anatomic depot显示文摘 | ANTUNES Tr GAGNON A CHEN B | 2006 | Am J physiol Endocrinol Metab2006，290，6： | 1 |
| 20 | Alkaline PF resins linear extension by urea condensation with hydroxybenzyalchohol groups显示文摘 | PIZZI A STEPHANOU A ANTUNES I | 1993 | J Appl Polym Sci1993，50，： | 1 |
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