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| 1 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | Fate and Transport of Antibiotic Residues and Antibiotic Resistance Genes following Land Application of Manure Waste显示文摘 | Chee-Sanford Joanne C Mackie Roderick I Koike Satoshi Krapac Ivan G Lin Yu-Feng Yannarell Anthony C Maxwell Scott Aminov Rustam I | 2009 | Journal of Environmental Quality2009，，3： | 3 |
| 4 | The neuropathology of HIV/AIDS 显示文摘 | ANTHONY I C BELL J E | 2008 | Int Rev Psychiatry2008，20，1： | 1 |
| 5 | Growth re- sponses of Tilapia zillii fed diets containing various levels of ascorbic acid and cobalt chloride 显示文摘 | ANADU D I ANOZIE O C ANTHONY A D | 1990 | Aquaculture1990，88，34： | 1 |
| 6 | Comparing the incidence of anterior cruciate ligament injury in collegiate lacrosse,soccer,and basketball players implications for anterior cruciate ligament mechanism and prevention显示文摘 | LEANNE C S MIHATA ANTHONY I | 2006 | The American Journal of Sports Medicine2006，34，： | 1 |
| 7 | Electrochemical remediation produces a new high-nitrogen compound from NTO wastewaters显示文摘 | MICHAEL P C ANTHONY I D LYNNE W | 2007 | Journal of Hazardous Materials2007，149，： | 1 |
| 8 | Growth responses of Tilapia zillii fed diets containing various levels of ascorbic acid and cobalt chloride 显示文摘 | Anadu D I Anozie O C Anthony A D | 1990 | Aquaculture1990，88，： | 1 |
| 9 | Revisiting the Miles and Snow Strategic Framework: Uncovering Interrelationships between Strategic Types, Capabilities, Environmental Un- certainty, and Firm Performance显示文摘 | DESARBO W S ANTHONY D I BENEDETTO C | 2005 | Strategic Man- agement Journal2005，26，1： | 1 |
| 10 | Activation of Cennabinoid CB2 Receptor-Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury显示文摘 | Choi I Y Ju C Anthony Jalin A M | 2013 | Am J Pathol2013，182，3： | 1 |
| 11 | Human thrombin and FXa mediate porcine endothelial cell activation;modulation by expression of TFPI-CD4 and hirudin-CD4 fusion proteins 显示文摘 | Riesbeck K McVey J H Geoff K C Edward G D T Robert I L Anthony D | 2001 | Xenotransplantation2001，8，4： | 1 |
| 12 | Growth responses of Tilapia zillii fed diets containing various levels of ascorbic acid and cobalt chloride显示文摘 | Anadu D I Anozie O C Anthony A D | 1990 | Aquaculture1990，88，： | 1 |
| 13 | Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat 显示文摘 | Angela C Sveva B Michela P Saverio S Andrea C Lisa G Jenny T Martina P Elisabetta L Gino G Igor V Emanuele C Annalisa A Laura I Giovanni F Z Anthony A Paolo D C and Saverio S | 2007 | Journal of Molecular and Cellular Cardiology2007，42，4： | 1 |
| 14 | Bats are a major natural reservoir for hepaeiviruses and pegiviruses显示文摘 | Quan P L Firth C Conte J M Williams S H Zam- brana-Torrelio C M Anthony S J Ellison J A Gilbert A T Kuzmin I V Niezgoda M Osinubi M O Re-cuenco S Markotter W Breiman R F Kalemba L Malekani J Lindblade K A Rostal M K Ojeda-Flores R Suzan G Davis L B Blau D M Ogunkoya A B Alvarez Castillo D A Moran D Ngam S Akaibe D Agwanda B Briese T Epstein J H Daszak P Rup- precht C E Holmes E C Lipkin W I | 2013 | PNAS2013，110，20： | 1 |
| 15 | Phase Diagram Prediction for a Blend of PPE/Epoxy Resin During Reaction Induced Phase Separation 显示文摘 | Yoshiyuki I Anthony J R Nigel C | 2003 | Polymer2003，44，： | 1 |
| 16 | Hyperparathyroidism in a Patient with Wilson' s Disease 显示文摘 | George A Michael I Anthony C | 1990 | Clin Chem1990，36，3： | 1 |
| 17 | Regulatory T cell activity in primary and persistent Epstein-Barr virus infection显示文摘 | Wingate P J Mc Aulay K A Anthony I C | 2009 | J Med Virol2009，81，5： | 1 |
| 18 | Molecular epidemiology of norovirus in outbreaks of gastroenteritis in southwest Germany from 2001 to 2004显示文摘 | Anthony C I Stefan O Brockmann | 2006 | J Clin Microbiol2006，44，4： | 1 |
| 19 | The mean-ing of cognitive impairment in the elderly显示文摘 | Folstein M Anthony J C Parhad I | 1985 | J Am Geriatr Soc1985，33，2： | 1 |
| 20 | Dexmedetomidine and meperidine additively reduce the shivering threshold in humans显示文摘 | ANTHONY G LIN C M SULEMAN M I | 2003 | Stroke2003，34，5： | 1 |
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