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| 1 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 2 | 7-year survey after percutaneous dilatational tracheotomy on a medical intensive care unit显示文摘 | PIA L ANNEMARIE S EMEL G | 2010 | J Investigat Med2010，58，8： | 1 |
| 3 | Transmission of a live Eimeria acervulina vaccine strain and response to infection in vaccinated and contact-vaccinated broilers显示文摘 | Francisca C V Annemarie B Arjan S J | 2012 | Vaccine2012，30，2： | 1 |
| 4 | Localization of γ-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease显示文摘 | Irfan Rahman Annemarie A.M van Schadewijk Pieter S Hiemstra Jan Stolk J.Han J.M van Krieken William MacNee Willem I de Boer | 2000 | Free Radical Biology and Medicine2000，，： | 1 |
| 5 | Apoptosis of human abdominal preadipocytes before and after differentiation into adipocytes in culture显示文摘 | Denise P AnneMarie G Alexander S | 2003 | Metabolism2003，52，8： | 1 |
| 6 | Liposome mediated depletion of mac- rophages mechanism of action preparation of liposomes and appli- cation显示文摘 | NICO R ANNEMARIE S | 1994 | JlmmunolMethods1994，174，12： | 1 |
| 7 | Scald burns in the bathroom: accidental or inflicted? 显示文摘 | SINTHA D S ANNEMARIE M C CAN R | 2004 | Pe diateics2004，113，： | 1 |
| 8 | Children as passengers in automobiles:the neglected minority on the nation's highways显示文摘 | Annemarie S Seymour C | 1975 | Pediatrics1975，56，2： | 1 |
| 9 | Expression of VEGF and PEDF in choroidal neovascular membranes following verteporfin photodynamic therapy 显示文摘 | OLCAY T ANNEMARIE A KEI S | 2006 | Am J Ophthalmol2006，142，1： | 1 |
| 10 | Scoping review on health-related physical fitness in patients with inflammatory bowel disease:Assessment,interventions,and future directions显示文摘BACKGROUND Reaching the Selecting Therapeutic Targets in Inflammatory Bowel Disease-II(STRIDE-II)therapeutic targets for inflammatory bowel disease(IBD)requires an interdisciplinary approach.Lifestyle interventions focusing on enhancing and preserving health-related physical fitness(HRPF)may aid in improving subjective health,decreasing disability,or even controlling inflammation.However,ambiguity remains about the status and impact of HRPF(i.e.body composition,cardiorespiratory fitness,muscular strength,muscular endurance,and flexibility)in IBD patients,hindering the development of physical activity and physical exercise training guidelines.AIM To review HRPF components in IBD patients and the impact of physical activity and physical exercise training interventions on HRPF.METHODS A systematic search in multiple databases was conducted for original studies that included patients with IBD,assessed one or more HRPF components,and/or evaluated physical activity or physical exercise training interventions.RESULTS Sixty-eight articles were included.No study examined the complete concept of HRPF,and considerable heterogeneity existed in assessment methods,with frequent use of non-validated tests.According to studies that used gold standard tests,cardiorespiratory fitness seemed to be reduced,but findings on muscular strength and endurance were inconsistent.A limited number of studies that evaluated physical activity or physical exercise training interventions reported effects on HRPF,overall showing a positive impact.CONCLUSION We performed a scoping review using a systematic and iterative approach to identify and synthesize an emerging body of literature on health-related physical fitness in patients with IBD,highlighting several research gaps and opportunities for future research.Findings of this review revealed a gap in the literature regarding the accurate assessment of HRPF in patients with IBD and highlighted important methodological limitations of studies that evaluated physical activity or physical exercise training interventions.This scoping review is a step towards performing studies and systematic reviews in the future,which was not possible at present given the heterogeneity in endpoints and designs of the available studies on this topic.Future well-designed studies are required to determine the optimal training paradigm for improving HRPF in patients with IBD before guidelines can be developed and integrated into the therapeutic strategy. | Karlijn Demers Michiel T J Bak Bart C Bongers Annemarie C de Vries Daisy M A E Jonkers Marieke J Pierik Laurents P S Stassen | 2023 | World Journal of Gastroenterology2023，29，38： | 1 |
| 11 | Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial显示文摘 | Annemarie E Brouwer Adul Rajanuwong Wirongrong Chierakul George E Griffin Robert A Larsen Nicholas J White Thomas S Harrison | 2004 | The Lancet2004，，9423： | 1 |
| 12 | Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial显示文摘 | Annemarie E Brouwer Adul Rajanuwong Wirongrong Chierakul George E Griffin Robert A Larsen Nicholas J White Thomas S Harrison | 2004 | The Lancet . 2004 (9423)2004，，9423： | 1 |
| 13 | Design of short high-power TE11-HEu mode converters in highly overmoded corrugated waveguides 显示文摘 | Manfred T Annemarie J Mario S A | 1991 | IEEE Trans on Microw Theory Tech1991，39，2： | 1 |
| 14 | Endothelial dysfunction contributes to renal function- associated cardiovascular mortality in a population with mild renal insufficiency: the hoom study显示文摘 | Frank S Coenvan G Annemarie B | 2006 | J Am Soc Nephrol2006，17，4： | 1 |
| 15 | Conjugation,immunoreactivity,and immunogenicity of calixarenes;model study to potential calixarene-based Ac3+chelators显示文摘 | Marcel H B Grote Gansey Annemarie Sde Haan Ebo S Bos | 1999 | Bioconjugate Chemistry1999，10，4： | 1 |
| 16 | When can a veterinarian be expected to detect classical swine fever virus among breeding sows in a herd during an outbreak?显示文摘 | Bas E Annemarie B Arjan S | 2005 | Pre Vet Med2005，67，23： | 1 |
| 17 | Transforming growth factor-β1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease显示文摘 | Willem I de boer Annemarie van schadewijk Jacobk S | 1998 | Am J Respir Crit Care Med1998，158，： | 1 |
| 18 | Effects of climate-in- duced increases in summer drought on riparian plant species: a meta-analysis显示文摘 | Annemarie G G Jos T A V Merel B S | 2014 | Freshwater Biology2014，59，5： | 1 |
| 19 | Maternal and perinatal outcome of preeclampsia with an onset before 24 weeks' gestation Audit in a tertiary referral center显示文摘 | Ingrid P M Gaugler S Annemarie G H | 2006 | European Journal of Obstetrics & Gynecology and Reproductive Biology2006，128，： | 1 |
| 20 | Global gene expression analysis reveals specific patterns of cell junctions in non-small cell lung cancer subtypes显示文摘 | Ruprecht Kuner Thomas Muley Michael Meister Markus Ruschhaupt Andreas Buness Elizabeth C. Xu Phillipp Schnabel Arne Warth Annemarie Poustka Holger Sültmann Hans Hoffmann | 2008 | Lung Cancer2008，，1： | 1 |
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