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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Positive solu- tions for a quasilinear elliptic equations of Kirchhoff type显示文摘 | Alves C O Correa F J S A Ma T F | 2005 | Comput Math Appl2005，4，： | 1 |
| 3 | On the existence and con- centration behaviour of ground state solutions for a class of problems with critical growth 显示文摘 | Alves C O Souto M A S | 2002 | Comm Pure Appl Anal2002，3，： | 1 |
| 4 | Formation of complemen-t activating particles in aqueous solutions of Taxol:poss-ible role in hypersensitivity reactions显示文摘 | SZEBENI J ALVING C R SAVAV S | 2001 | Int Immunopharmacol2001，1，4： | 1 |
| 5 | On systems of elliptic equations involving subcritical or critical Sobolev exponents显示文摘 | Alves C O Filho D C de M Souto M A S | 2000 | Nonlinear Analysis2000，42，： | 1 |
| 6 | New multi-phase catalytic systems based on tin compounds active for vegetable oil transesterification reaction 显示文摘 | Abreu F R Melquizedeque B Alves Caio C S | 2005 | Journal of Molecular catalysis A : Chenmical2005，227，： | 1 |
| 7 | Changes in volatile com- position of Madeira wines during their oxidative ageing显示文摘 | Ci MARA J S ALVES M A MARQUES J C | 2006 | Anal Chim Acta2006，563，1： | 1 |
| 8 | Positive Solutions for a Quasilinear Elliptic Equation of Kirchhoff Type 显示文摘 | ALVES C O CORREA F J S A MAT F | 2005 | Comput Math Appl2005，49，： | 1 |
| 9 | Phosdhatidvlserine reverses reserpine: induced amnesia显示文摘 | ALVES C S ANDREATINI R CUNHA C D | 2000 | European Journal of Pharmacology2000，404，12： | 1 |
| 10 | Mitochondrial degradation in acetic acid-induced yeast apoptosis: the role of Pep4 and the ADP/ATP carrier显示文摘 | Pereira C Chaves S Alves S | 2010 | Mol Micr- obiol2010，76，6： | 1 |
| 11 | Nitriding of titanium disks and industrial dental implants using hollow cathode discharge显示文摘 | Jr ALVES C GUERRA NETO C L B MORAIS G H S | 2006 | Surface and Coatings Technology2006，200，： | 1 |
| 12 | Preferences of Older People for Environmental Attributes of Local Parks: The Use of Choice-Based Conjoint Analysis显示文摘 | ALVES S ASPINALL P A THOMPSON C W | 2008 | Facilities2008，26，1112： | 1 |
| 13 | Experimental and modeling study of gas dispersion in a double turbine stirred tank显示文摘 | Alves S S Maia C I Vasconcelos J M T | 2002 | Chemical Engineering Science2002，57，： | 1 |
| 14 | Effects of furadan in the brown mussel Perna pernaand in mangrove oyster Crassostrea rhizophorae显示文摘 | Alves S R C Severino P C Ibboston D P | 2002 | Marine Environmental Research2002，54，35： | 1 |
| 15 | Ultrasonic Evaluation of the Physical and MechanicalProperties of Granites显示文摘 | VASCONCELOS G LOURENCO PB ALVES C A S | 2008 | Ultrasonics2008，48，6： | 1 |
| 16 | Validity, reliability, feasibility and satisfaction of the mini-clinical evaluationexereise (mini-CEX) for cardiology residency training 显示文摘 | Alves de Lima A Barrero C Baratta S | 2007 | Med Teach2007，29，8： | 1 |
| 17 | Physical exercise prevents and mitigates non-alcoholic steatohepatitis-induced liver mitochondrial structural and bioenergetics impairments显示文摘 | Inês O. Gon?alves Emanuel Passos Silvia Rocha-Rodrigues Cátia V. Diogo Joan R. Torrella David Rizo Ginés Viscor Estela Santos-Alves Inês Marques-Aleixo Paulo J. Oliveira António Ascens?o José Magalh?es | 2014 | Mitochondrion2014，，： | 1 |
| 18 | The influence of the dispersion technique on the characteristics of the W-Cu powders and on the sintering behavior显示文摘 | da ALVES F C da PEREIRA A G S GOMES U U | 2003 | Powder Technology2003，134，12： | 1 |
| 19 | Structureproperty studies on the antioxidant activity of flavonoids present in diet显示文摘 | TEIXEIRA S SIQUET C ALVES C | 2005 | Free Radical Bio Med2005，39，8： | 1 |
| 20 | Mitochondrial degradation in acetic acid-induced yeast apoptosis: the role of Pep4 and the ADP/ATP carrier显示文摘 | Pereira C Chaves S Alves S | 2010 | Mol Microbiol2010，76，6： | 1 |
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