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| 1 | Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis显示文摘AIM:To evaluate the impact of metadoxine(MTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis(AH).METHODS:This study was an open-label clinical trial,performed at the'Hospital General de México,Dr.Eduardo Liceaga'.We randomized 135 patients who met the criteria for severe AH into the following groups:35 patients received prednisone(PDN)40 mg/d,35patients received PDN+MTD 500 mg three times daily,33 patients received pentoxifylline(PTX)400 mg three times daily,and 32 patients received PTX+MTD 500 mg three times daily.The duration of the treatment for all of the groups was 30 d.RESULTS:In the groups treated with the MTD,thesurvival rate was higher at 3 mo(PTX+MTD 59.4%vs PTX 33.3%,P=0.04;PDN+MTD 68.6%vs PDN20%,P=0.0001)and at 6 mo(PTX+MTD 50%vs PTX18.2%,P=0.01;PDN+MTD 48.6%vs PDN 20%,P=0.003)than in the groups not treated with MTD.A relapse in alcohol intake was the primary independent factor predicting mortality at 6 mo.The patients receiving MTD maintained greater abstinence than those who did not receive it(74.5%vs 59.4%,P=0.02).CONCLUSION:MTD improves the 3-and 6-mo survival rates in patients with severe AH.Alcohol abstinence is a key factor for survival in these patients.The patients who received the combination therapy with MTD were more likely to maintain abstinence than those who received monotherapy with either PDN or PTX. | Fátima Higuera-de la Tijera Alfredo I Servín-Caamano Aurora E Serralde-Zúniga Javier Cruz-Herrera Eduardo Pérez-Torres Juan M Abdo-Francis Francisco Salas-Gordillo JoséL Pérez-Hernández | 2015 | World Journal of Gastroenterology2015，21，16： | 8 |
| 2 | Malnutrition negatively impacts the quality of life of patients with cirrhosis: An observational study显示文摘AIM To verify how malnutrition is related to health-related quality of life(HRQL) impairment in patients with cirrhosis.METHODS Data was retrospectively abstracted from medical records and obtained by direct interview. We included patients with cirrhosis from any etiology, evaluated at the Liver Clinic from Gastroenterology Department in a tertiary healthcare center, from June 2014 to June 2016. Child-Pugh score, data about complications, and demographic, clinical and anthropometric characteristics of patients were obtained. Nutritional status was evaluated by the Subjective Global Assessment(SGA). HRQL was evaluated through the Chronic Liver Disease Questionnaire. Patients were requested to assess their global HRQL with the following code: 0 = impairment of HRQL, when it was compared with other healthy subjects; 1 = good HRQL, if it was similar to the quality of life of other healthy subjects. To compare the primary outcome between malnourished and well-nourished groups, the χ~2 test, Fisher's exact test or Student's t-test were used, based on the variable type. Associations between predictor variables and deterioration of HRQL were determined by calculating the hazard ratio and 95% confidence interval using Cox proportional hazards regression. RESULTS A total of 127 patients with cirrhosis were included, and the mean age was 54.1 ± 12.3 years-old. According to Child-Pugh scoring, 25(19.7%) were classified as A(compensated), 76(59.8%) as B, and 26(20.5%) as C(B/C = decompensated). According to SGA, 58(45.7%) patients were classified as well-nourished. Sixty-nine patients identified HRQL as good, and 76 patients(59.8%) perceived impairment of their HRQL. Multivariate analysis to determine associations between predictor variables and self-perception of an impairment of HRQL found strong association with malnutrition(P < 0.0001). The most important impaired characteristics in malnourished patients were: Presence of body pain, dyspnea on exertion with daily activities, decreased appetite, generalized weakness, trouble lifting or carrying heavy objects, and decreased level of energy(P < 0.0001).CONCLUSION Malnutrition is a key factor related to impairment of HRQL in patients with cirrhosis. | Gabriela Rojas-Loureiro Alfredo Servín-Caamano Elizabeth Pérez-Reyes Luis Servín-Abad Fátima Higuerade la Tijera | 2017 | World Journal of Hepatology2017，9，5： | 3 |
| 3 | The effect of ionic products from bioactive glass dissolution on osteoblast proliferation and collagen production显示文摘 | Patricia V Marivalda M P Alfredo M G | 2004 | Biomaterials2004，25，： | 1 |
| 4 | Horizontal and vertical variability of soil properties in a trace element contaminated area显示文摘 | Pilar Burgos Engracia Madejón Alfredo Pérez-de-Mora Francisco Cabrera | 2007 | International Journal of Applied Earth Observations and Geoinformation2007，，1： | 1 |
| 5 | Spatial variability of the chemical characteristics of a trace-element-contaminated soil before and after remediation显示文摘 | Pilar B Engracia M Alfredo P | 2006 | Geoderma2006，30，： | 1 |
| 6 | Microbial production of fructosyltransferases for synthesis of prebiotics显示文摘 | ALFREDO E M ROSANE M P ELDA S S | 2008 | Biotechnology Letters2008，30，11： | 1 |
| 7 | Re - engineering the toilet for sustainable wastewater management 显示文摘 | Tove AL Irene P Alfredo A | 2001 | ES&T2001，35，9： | 1 |
| 8 | A DSP-based FFF-Analyzer for the Fault Diagnosis of Rota- ting Machine Based on Vibration Analysis 显示文摘 | GIOVANNI B CONSOLATINA L ALFREDO P | 2001 | IEEE Instru- mentation and Measurement Technology Conference2001，3，21： | 1 |
| 9 | “In Situ” Amendments and Revegetation Reduce Trace Element Leaching in a Contaminated Soil显示文摘 | Alfredo Pérez-de-Mora Pilar Burgos Francisco Cabrera Engracia Madejón | 2007 | Water Air and Soil Pollution (-)2007，，1： | 1 |
| 10 | A self-organizing approach to background subtraction for visual surveillance applications 显示文摘 | Lucia M Alfredo P | 2008 | IEEE Transactions on IP2008，17，7： | 1 |
| 11 | Solid phase extraction of Pb(II) in water samples using a new hybrid inorganic-organic mesoporous silica prior to its determination by FAAS显示文摘 | Damián Pérez-Quintanilla Alfredo Sánchez Isabel del Hierro Mariano Fajardo Isabel Sierra | 2009 | Microchimica Acta (-)2009，，3： | 1 |
| 12 | Preparation, characterization, and Zn 2+ adsorption behavior of chemically modified MCM-41 with 5-mercapto-1-methyltetrazole显示文摘 | Damián Pérez-Quintanilla Alfredo Sánchez Isabel del Hierro Mariano Fajardo Isabel Sierra | 2007 | Journal of Colloid And Interface Science2007，，2： | 1 |
| 13 | Use of two biomar- kers ( CYP450 and acetylcholinesterase) in zebra mussel for the biomonitoring of Lake Maggiore (northern Italy) 显示文摘 | FRANCESCO R ANDREA B ALFREDO P | 2006 | Ecotoxicol- ogy and Environmental Safety2006，63，： | 1 |
| 14 | A self-organizing approach to background subtraction for visual surveillance applications 显示文摘 | Lucia M Alfredo P | 2008 | IEEE Transactions on Image Processing2008，17，7： | 1 |
| 15 | Electron transfer via or- ganic dyes for solar conversion 显示文摘 | ALFREDO O CEORGINA P | 1999 | Solar Energy Materials and Solar Cells1999，59，： | 1 |
| 16 | 显示文摘 | ALFREDO A M IGUEL P | 1992 | J Chem Phys1992，96，： | 1 |
| 17 | Re-engineering the toilet for sustainable wastewater management 显示文摘 | Tove A L Irene P Alfredo A | 2001 | ES&T2001，35，9： | 1 |
| 18 | A self-organizing approach to background subtraction for visual surveillance applications显示文摘 | LUCIA M ALFREDO P | 2008 | IEEE Transactions on Image Processing2008，17，7： | 1 |
| 19 | Airway clearance therapy in cystic fibro sis patients显示文摘 | Giovanna P Alfredo C | 2009 | Agricultural Biomed2009，80，： | 1 |
| 20 | Cyclic Elastoplastic Analysis of StructuresConcerning a Fatigue Assessment According to the LocalStrain Approach: An Overview 显示文摘 | Abilio M P De Jesus Helder F S G Pereira* Alfredo SRibeiro | 2008 | Journal of PressureVessel Technology2008，130，8： | 1 |
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