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| 1 | Veno occlusive disease: Update on clinical management显示文摘Hepatic veno-occlusive disease is a clinical syndrome characterized by hepatomegaly, ascites, weight gain and jaundice, due to sinusoidal congestion which can be caused by alkaloid ingestion, but the most frequent cause is haematopoietic stem cell transplantation (STC) and is also seen after solid organ transplantation. The incidence of veno occlusive disease (VOD) after STC ranges from 0 to 70%, but is decreasing. Survival is good when VOD is a mild form, but when it is severe and associated with an increase of hepatic venous pressure gradient > 20 mmHg, and mortality is about 90%. Prevention remains the best therapeutic strategy, by using non-myeloablative conditioning regimens before STC. Prophylactic administration of ursodeoxycholic acid, being an antioxidant and antiapoptotic agent, can have some benefit in reducing overall mortality. Defibrotide, which has pro-fibrinolytic and antithrombotic properties, is the most effective therapy; decompression of the sinusoids by a transjugular intrahepatic portosystemic shunt (TIPS) can be tried, especially to treat VOD after liver transplantation and when multiorgan failure (MOF) is not present. Liver transplantation can be the last option, but can not be considered a standard rescue therapy, because usually the concomitant presence of multiorgan failure contraindicates this procedure. | M Senzolo G Germani E Cholongitas P Burra AK Burroughs | 2007 | World Journal of Gastroenterology2007，13，29： | 19 |
| 2 | New insights into the coagulopathy of liver disease and liver transplantation显示文摘The liver is an essential player in the pathway of coagulation in both primary and secondary haemostasis. Only von Willebrand factor is not synthetised by the liver, thus liver failure is associated with impairment of coagulation. However, recently it has been shown that the delicate balance between pro and antithrombotic factors synthetised by the liver might be reset to a lower level in patients with chronic liver disease. Therefore, these patients might not be really anticoagulated in stable condition and bleeding may be caused only when additional factors, such as infections, supervene. Portal hypertension plays an important role in coagulopathy in liver disease, reducing the number of circulating platelets, but platelet function and secretion of thrombopoietin have been also shown to be impaired in patients with liver disease. Vitamin K deficiency may coexist, so that abnormal clotting factors are produced due to lack of gamma carboxylation. Moreover during liver failure, there is a reduced capacity to clear activated haemostatic proteins and protein inhibitor complexes from the circulation. Usually therapy for coagulation disorders in liver disease is needed only during bleeding or before invasive procedures. When end stage liver disease occurs, liver transplantation is the only treatment available, which can restore normal haemostasis, and correct genetic clotting defects, such as haemophilia or factor V Leiden mutation. During liver transplantation haemorrage may occur due to the pre-existing hypocoagulable state, the collateral circulation caused by portal hypertension and increased fibrinolysis which occurs during this surgery. | M Senzolo P Burra E Cholongitas AK Burroughs | 2006 | World Journal of Gastroenterology2006，12，48： | 12 |
| 3 | Randomised controlled trials of ursodeoxycholic - acid therapy for primary biliary cirrhosis : a meta-analysis 显示文摘 | GOULIS J LEANDRO G BURROUGHS AK | 1999 | Lancet1999，354，： | 1 |
| 4 | Transjugular intrahepatic porto- systemic shunt versus endoscopic therapy; randomized trials for secondary prophylaxis of vaficeal bleeding, an updated rneta - analysis显示文摘 | BURROUGHS AK VANGELI M | 2002 | Scand J Gastroenterol2002，37，3： | 1 |
| 5 | Controversies in the management of bleeding esophageal varices (2) 显示文摘 | Terblanche J Burroughs AK Hobbs KE | 1989 | N Engl J Med1989，320，22： | 1 |
| 6 | Non-invasive tests for liver fibrosis:encouraging or discouraging results显示文摘 | Burroughs AK Cholongitas E | 2007 | J Hepatol2007，46，5： | 1 |
| 7 | Grading of cellular rejection after orthotopic liver transplantation 显示文摘 | Hudson M Burroughs AK | 1995 | Hepatology1995，21，1： | 1 |
| 8 | Assessment of value of consensus definitions inacute variceal bleeding显示文摘 | | 2001 | Lancet2001，357，： | 1 |
| 9 | Gastrointestinal bleeding:Carvedilol-the best beta-blocker for primary prophylaxis显示文摘 | Tsochatzis EA Triantos CK Burroughs AK | 2009 | Nat Rev Gastroenterol Hepatol2009，6，12： | 1 |
| 10 | Management of varices inpatients with cirrhosis 显示文摘 | QBrien J Triantos C Burroughs AK | 2013 | Nat Rev Gastroenterol Hepatol2013，10，7： | 1 |
| 11 | Lamivudine prophylaxis against reinfection in liver transplantation for hepatitis B cirrhosis显示文摘 | L Grellier D Mutimer M Ahmed D Brown AK Burroughs K Rolles P McMaster P Beranek F Kennedy H Kibbler P McPhillips E Elias G Dusheiko | 1996 | 1996 (9036)1996，，9036： | 1 |
| 12 | Peptic ulcer and its course In cirrhosis:an endoscopic and clinical prospective study显示文摘 | Siringo S Burroughs AK Bolondi L | 1995 | J Hepatol1995，22，6： | 1 |
| 13 | Desmopressin and bleeding time in patients with cirrhosis显示文摘 | Burroughs AK Matthews K Quadira M | | 0，，： | 1 |
| 14 | Gastro- intestinal bleeding: carvedilol - the best beta - blocker for pri- mary prophylaxis? 显示文摘 | TSOCHATZIS EA TRIANTOS CK BURROUGHS AK | 2009 | Nat Rev Gastroenterol Hepatol2009，6，12： | 1 |
| 15 | Peptic ulcer and its course incirrhosis: an endoscopic and clinical prospective study 显示文摘 | Siringo S Burroughs AK Bolondi L | 1995 | J Hepatol1995，22，6： | 1 |
| 16 | How to prevent varices from bleeding: shades of grey-the case for nonselective beta blockers显示文摘 | Thalheimer U Bosch J Burroughs AK | 2007 | Gastroenterology2007，133，6： | 1 |
| 17 | Liver grafts from anti-hepatitis B core positive donors: a systematic review显示文摘 | Cholongitas E Papatheodoridis GV Burroughs AK | 2010 | J Hepatol2010，52，2： | 1 |
| 18 | Correction of both prothrombin time and primary haemostasis by recombinant factor Ⅶ during therapeutic alcohol inection显示文摘 | Papatheodoridis G Chung S Keshav S Pasi J Burroughs AK | | 0，，： | 1 |
| 19 | Systematic review and meta-analysis of intraoperative versus preoperative endoscopic sphincterotomy in patients with gallbladder and suspected common bile duct stones显示文摘 | Gurusamy K Sahay SJ Burroughs AK | 2011 | Br J Surg2011，98，7： | 1 |
| 20 | Grading of cellular rej ection after orthotopic liver transplantation显示文摘 | Datta-Gupta S Hudson M Burroughs AK | 1995 | Hepatology1995，21，1： | 1 |
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