Impact of short-term ambient air pollution exposure on the risk of severe COVID-19

查看全文 作　　者：Baihuan [1,2,3]Feng;Jiangshan [4]Lian;Fei [1,2,3]Yu;Dan [1,2,3]Zhang;Weizhen [1,2,3]Chen;[1,2,3]QiWang;Yifei [1,2,3]Shen;Guoliang [1,2,3]Xie;Ruonan [1,2,3]Wang;Yun [1,2,3]Teng;Bin [1,2,3]Lou;Shufa [1,2,3]Zheng;Yida [4,5]Yang;Yu [1,2,3,4]Chen 机构地区：[1]Department of Laboratory Medicine,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China;[2]Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province,Hangzhou 310000,China;[3]Institute of Laboratory Medicine,Zhejiang University,Hangzhou 310000,China;[4]Department of Infectious Diseases,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China;[5]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,China 出　　处：《Journal of Environmental Sciences》索引2024年第1期,共9页 基　　金：supported by the National Natural Science Foundation of China (Nos.82072377 and 81971919)。 摘　　要：Ecological studies suggested a link between air pollution and severe COVID-19 outcomes,while studies accounting for individual-level characteristics are limited.In the present study,we aimed to investigate the impact of short-term ambient air pollution exposure on disease severity among a cohort of 569 laboratory confirmed COVID-19 patients admitted to designated hospitals in Zhejiang province,China,from January 17 to March 3,2020,and elucidate the possible biological processes involved using transcriptomics.Compared with mild cases,severe cases had higher proportion of medical conditions as well as unfavorable results in most of the laboratory tests,and manifested higher air pollution exposure levels.Higher exposure to air pollutants was associated with increased risk of severe COVID-19 with odds ratio(OR)of 1.89(95%confidence interval(CI):1.01,3.53),2.35(95%CI:1.20,4.61),2.87(95%CI:1.68,4.91),and 2.01(95%CI:1.10,3.69)for PM_(2.5),PM_(10),NO_(2)and CO,respectively.OR for NO_(2)remained significant in two-pollutant models after adjusting for other pollutants.Transcriptional analysis showed 884 differentially expressed genes which mainly were enriched in virus clearance related biological processes between patients with high and low NO_(2)exposure levels,indicating that compromised immune response might be a potential underlying mechanistic pathway.These findings highlight the impact of shortterm air pollution exposure,particularly for NO_(2),on COVID-19 severity,and emphasize the significance in mitigating the COVID-19 burden of commitments to improve air quality. 关 键 词：Air pollution COVID-19 SEVERITY TRANSCRIPTOMICS Immune response