Population genetics and forensic efficiency of 30 InDel markers in four Chinese ethnic groups residing in Sichuan

查看全文 作　　者：Fei [1]Wang;Guanglin [1]He;Zheng [1]Wang;Mengge [1]Wang;Jing [1]Liu;Xing [1]Zou;Shouyu [1]Wang;Mengyuan [1]Song;Ziwei [1]Ye;Mingkun [1]Xie;Yiping [1]Hou

机构地区：[1]Institute of Forensic Medicine,West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,Chengdu,China

出　　处：《Forensic Sciences Research》索引2022年第7卷第3期,共5页

基　　金：study was carried out with the grants from the National Natural Science Foundation of China[grant number 81571854];the Open Project of Key Laboratory of Forensic Genetics in Ministry of Public Security[grant number 2017FGKFKT01];the Fundamental Research Funds for the Central Universities[grant number 20826041 A4408,YJ201651 and 2012017yjsy187]. 摘　　要：Sichuan Province is located at the transitional junction regions of the Qinghai-Tibet Plateau and the low-altitude plains.It also serves as the corridor of Sino Tibetan-speaking population migration and expansion since neolithic expansion of Proto-Tibeto-Burman populations from Middle/Upper Yellow River during Majiayao period(3300-2000 BC).However,the population structure and the corresponding genetic diversity of forensic-related markers in this region remain unclear.Thus,we genotyped 30 insertion-deletion(InDel)markers in 444 samples from four ethnic groups(Han,Tibetan,Hui and Yi)from Sichuan Province using the Investigator■ DIPplex kit to explore the characteristics of population genetics and forensic genetic focuses.All the loci were found to be in Hardy-Weinberg Equlibrium(HWE)after applying a Bonferroni correction and no pairwise loci showed prominent linkage disequilibrium.The combined matching probability(CMP)and the combined power of discrimination(CPD)are larger than 1.8089×10^(11)and 0.9999999995,respectively.Principal component analysis,multi-dimen-sional scaling plots and Neighbour-Joining tree among 65 worldwide populations indicated that Sichuan Hui and Han are genetically close to Hmong-Mien and Tai-Kadai-speaking popula-tions,and Sichuan Tibetan and Yi bear a strong genetic affinity with Tibeto-Burman-speaking populations.The model-based genetic structure further supports the genetic affinity between the studied populations and linguistically close populations. 关键词：Forensic sciences INDEL population genetics Sichuan Han Sichuan Yi Sichuan Tibetan Sichuan Hui

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Population genetics and forensic efficiency of 30 InDel markers in four Chinese ethnic groups residing in Sichuan

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