Biotin biosynthesis in Mycobacterium tuberculosis: physiology, biochemistry and molecular intervention

查看全文 作　　者：Wanisa [1]Salaemae;Al [1]Azhar;Grant [1]W.Booker;Steven [1]W.Polyak

机构地区：[1]School of Molecular and Biomedical Sciences,University of Adelaide,South Australia 5005,Australia

出　　处：《Protein & Cell》索引2011年第2卷第9期,共5页

基　　金：supported by the National Health and Medical Research Council of Australia and the Australian Academy of Science International Linkage Scheme. 摘　　要：Biotin is an important micronutrient that serves as an essential enzyme cofactor.Bacteria obtain biotin either through de novo synthesis or by active uptake from exogenous sources.Mycobacteria are unusual amongst bacteria in that their primary source of biotin is through de novo synthesis.Here we review the importance of biotin biosynthesis in the lifecycle of Mycobacteria.Genetic screens designed to identify key metabolic processes have highlighted a role for the biotin biosynthesis in bacilli growth,infection and survival during the latency phase.These studies help to establish the biotin biosynthetic pathway as a potential drug target for new anti-tuberculosis agents. 关键词：synthesis. phase. SYNTHESIS

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Biotin biosynthesis in Mycobacterium tuberculosis: physiology, biochemistry and molecular intervention

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