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Recent advances in mammalian reproductive biology

查看全文 作  者:Lu [1]Wen;Qiang [1]Liu;Jingjing [3]Xu;Xixi [1]Liu;Chaoyi [3]Shi;Zuwei [3]Yang;Yili [3]Zhang;Hong [3]Xu;Jiang [5]Liu;Hui [4]Yang;Hefeng [3]Huang;Jie [1]Qiao;Fuchou [1]Tang;Zi-Jiang [2]Chen 高影响力作者 机构地区:[1]Beijing Advanced Innovation Center for Genomics,Department of Obstetrics and Gynecology Third Hospital,College of Life Sciences,Peking University,Beijing 100871,China;[2]National Research Center for Assisted Reproductive Technology and Reproductive Genetics,Jinan 250021,China;[3]International Peace Maternity and Child Health Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Key Laboratory of Embryo Original Diseases,Shanghai 200030,China;[4]Institute of Neuroscience,State Key Laboratory of Neuroscience,Key Laboratory of Primate Neurobiology,CAS Center for Excellence in Brain Science and Intelligence Technology,Shanghai Research Center for Brain Science and Brain-Inspired Intelligence,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China;[5]CAS Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China高影响力机构 出  处:《Science China(Life Sciences)》索引2020年第63卷第1期,共41页高影响力期刊 摘  要:Reproductive biology is a uniquely important topic since it is about germ cells, which are central for transmitting genetic information from generation to generation. In this review, we discuss recent advances in mammalian germ cell development,including preimplantation development, fetal germ cell development and postnatal development of oocytes and sperm. We also discuss the etiologies of female and male infertility and describe the emerging technologies for studying reproductive biology such as gene editing and single-cell technologies. 关 键 词:PREIMPLANTATION fetal germ cell OOGENESIS SPERMATOGENESIS female infertility male infertility gene editing single-cell sequencing
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