Lycium barbarum polysaccharides protects retinal ganglion cells against oxidative stress injury

查看全文 作　　者：Lian [1]Liu;Xiao-Yuan [1]Sha;Yi-Ning [2]Wu;Meng-Ting [1]Chen;Jing-Xiang [1]Zhong

机构地区：[1]Department of Ophthalmology,Affiliated First Hospital of Jinan University,Guangzhou,Guangdong Province,China;[2]Department of Ophthalmology,Guangdong Women and Children Hospital,Guangzhou,Guangdong Province,China

出　　处：《Neural Regeneration Research》索引2020年第15卷第8期,共6页

基　　金：supported by grants from Project of Administration of Traditional Chinese Medicine of Guangdong Province of China,No.20161071(to LL);Medical Scientific Research Foundation of Guangdong Province of China,No.A2019098(to LL) 摘　　要：The accumulation of excessive reactive oxygen species can exacerbate any injury of retinal tissue because free radicals can trigger lipid peroxidation,protein damage and DNA fragmentation.Increased oxidative stress is associated with the common pathological process of many eye diseases,such as glaucoma,diabetic retinopathy and ischemic optic neuropathy.Many studies have demonstrated that Lycium barbarum polysaccharides(LBP)protects against oxidative injury in numerous cells and tissues.For the model of hypoxia we used cultured retinal ganglion cells and induced hypoxia by incubating with 200μM cobalt chloride(CoCl2)for 24 hours.To investigate the protective effect of LBP and its mechanism of action against oxidative stress injury,the retinal tissue was pretreated with 0.5 mg/mL LBP for 24 hours.The results of flow cytometric analysis showed LBP could effectively reduce the CoCl2-induced retinal ganglion cell apoptosis,inhibited the generation of reactive oxygen species and the reduction of mitochondrial membrane potential.These findings suggested that LBP could protect retinal ganglion cells from CoCl2-induced apoptosis by reducing mitochondrial membrane potential and reactive oxygen species. 关键词：CASPASE cell apoptosis cobalt chloride Lycium barbarum polysaccharides mitochondrial membrane potential oxidative stress injury reactive oxygen species retinal ganglion cells

相关文献

参考文献（41）
引证文献（32）
耦合文献（79）

参考文献(41)

引证文献(32)

耦合文献(79)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Lycium barbarum polysaccharides protects retinal ganglion cells against oxidative stress injury

参考文献(41)

引证文献(32)

耦合文献(79)

用户提示