MicroRNAs in lung cancer

查看全文 作　　者：Pooja [1,2]Joshi;Justin [1,2]Middleton;Young-Jun [1,2]Jeon;Michela [1,2,3]Garofalo

机构地区：[1]Department of Molecular Virology,Immunology and Medical Genetics,Comprehensive Cancer Center,The Ohio State University Wexner Medical Center;[2]The Ohio State University,Columbus,OH 43210,United States;[3]Transcriptional Networks in Lung Cancer Group,Cancer Research UK Manchester Institute,University of Manchester,Manchester M20 4BX,United Kingdom

出　　处：《World Journal of Methodology》索引2014年第4卷第2期,共14页

摘　　要：Micro RNAs have become recognized as key players in the development of cancer. They are a family of small non-coding RNAs that can negatively regulate the expression of cancer-related genes by sequenceselective targeting of m RNAs, leading to either m RNA degradation or translational repression. Lung cancer is the leading cause of cancer-related death worldwide with a substantially low survival rate. Micro RNAs have been confirmed to play roles in lung cancer development, epithelial-mesenchymal transition and response to therapy. They are also being studied for their future use as diagnostic and prognostic biomarkers and as potential therapeutic targets. In this review we focus on the role of dysregulated micro RNA expression in lung tumorigenesis. We also discuss the role of micro RNAs in therapeutic resistance and as biomarkers. We further look into the progress made and challenges remaining in using micro RNAs for therapy in lung cancer. 关键词：LUNG CANCER MICRORNA MIRNA

相关文献

参考文献（146）
引证文献（13）
耦合文献（31）

参考文献(146)

引证文献(13)

耦合文献(31)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

MicroRNAs in lung cancer

参考文献(146)

引证文献(13)

耦合文献(31)

用户提示