Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease

查看全文 作　　者：Shane [1]V.Hegarty;Gerard W.O’[1]Keeffe;Aideen [1]M.Sullivan

机构地区：[1]Department of Anatomy and Neuroscience,Biosciences Institute,University College Cork

出　　处：《Neural Regeneration Research》索引2014年第9卷第19期,共4页

基　　金：supported by grants from the Irish Research Council(R13702 and R15897;SVH/AS/G’OK);the Health Research Board of Ireland(HRA/2009/127;GO’K/AS);Science Foundation Ireland(10/RFP/NES2786;GO’K) 摘　　要：Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson's disease. In Parkinson's disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson's disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5. 关键词：胶质细胞源性神经营养因子神经发育帕金森病监管机构多巴胺能神经元治疗疗法 NEURTURIN

相关文献

参考文献（34）
引证文献（6）
耦合文献（0）

参考文献(34)

引证文献(6)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease

参考文献(34)

引证文献(6)

用户提示