Acrylamide exposure impairs blood-cerebrospinal fluid barrier function

查看全文 作　　者：Xue [1]Yao;Licheng [1]Yan;Lin [2]Yao;Weijun [3]Guan;Fanxu [1]Zeng;Fuyuan [2]Cao;Yanshu [1]Zhang

机构地区：[1]College of Public Health,Hebei United University;[2]Experimental Animal Center, Hebei United University;[3]Key Laboratory of Hebei Health and Safety on Coal Industry, Hebei United University

出　　处：《Neural Regeneration Research》索引2014年第9卷第5期,共6页

基　　金：supported by State Key Development Program for Basic Research of China,No.2012CB525002;the National Natural Science Foundation of China,No.30771823 摘　　要：Previous studies show that chronic acrylamide exposure leads to central and peripheral neuropathy. However, the underlying mechanisms remained unclear. In this study, we examined the permeability of the blood-cerebrospinal fluid barrier, and its ability to secrete transthyretin and transport leptin of rats exposed to acrylamide for 7, 14, 21 or 28 days. Transthyretin levels in cerebrospinal fluid began to decline on day 7 after acrylamide exposure. The sodium fluorescein level in cerebrospinal fluid was increased on day 14 after exposure. Evans blue concentration in cerebrospinal fluid was increased and the cerebrospinal fluid/serum leptin ratio was decreased on days 21 and 28 after exposure. In comparison, the cerebrospinal fluid/serum albumin ratio was increased on day 28 after exposure. Our findings show that acrylamide exposure damages the blood-cerebrospinal fluid barrier and impairs secretory and transport functions. These changes may underlie acrylamide-induced neurotoxicity. 关键词：丙烯酰胺屏障功能脑脊液曝光血清白蛋白血液蛋白水平甲状腺素

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Acrylamide exposure impairs blood-cerebrospinal fluid barrier function

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