Animal models for the study of hepatitis C virus infection and replication

查看全文 作　　者：Kristin L [1]MacArthur;Catherine H [2]Wu;George Y [2]Wu

机构地区：[1]Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, United States;[2]Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT 06030-1845, United States

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第23期,共5页

摘　　要：Hepatitis C virus (HCV) hepatitis, initially termed non-A, non-B hepatitis, has become one of the leading causes of cirrhosis and hepatocellular carcinoma worldwide. With the help of animal models, our understanding of the virus has grown substantially from the time of initial discovery. There is a paucity of available animal models for the study of HCV, mainly because of the selective susceptibility limited to humans and primates. Recent work has focused modification of animals to permit HCV entry, replication and transmission. In this review, we highlight the currently available models for the study of HCV including chimpanzees, tupaia, mouse and rat models. Discussion will include methods of model design as well as the advantages and disadvantages of each model. Particular focus is dedicated to knowledge of pathophysiologic mechanisms of HCV infection that have been elucidated through animal studies. Research within animal models is critically important to establish a complete understanding of HCV infection, which will ultimately form the basis for future treatments and prevention of disease. 关键词：丙型肝炎病毒动物模型病毒感染复制灵长类动物乙型肝炎小鼠模型设计方法

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Animal models for the study of hepatitis C virus infection and replication

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