维普中文期刊产品整合服务

Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound

查看全文 作　　者：Ramin Schirin-[1]Sokhan;Ron [1]Winograd;Christoph [1]Roderburg;Jhenee [1]Bubenzer;Nicole Cabral do [1]ó;Dorothee [2]Guggenberger;Hartmut [3]Hecker;Christian [1]Trautwein;Jens J W [1]Tischendorf 高影响力作者 机构地区：[1]Department of Medicine Ⅲ,University Hospital Aachen(RWTH),Aachen 52074,Germany;[2]Oncological Medical Practice,Aachen 52064,Germany;[3]Institute of Biometry,Medical School of Hannover,Hannover 30625,Germany高影响力机构 出　　处：《World Journal of Gastroenterology》索引2012年第18卷第6期,共5页高影响力期刊 摘　　要：AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy. 关 键 词：临床反应 转移性 造影 超声 化疗 结直肠癌 评价 响应预测
相关文献

参考文献(13)

引证文献(17)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费