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Establishment of a rhesus monkey model of middle cerebral artery ischemia and reperfusion using a microcatheter embolization method

查看全文 作　　者：Jie [1]Yang;Jian [1]Guo;Hongbo [1]Zheng;Muke [1]Zhou;Li [1]He;Wenying [1]Cao;Li [1]Xiao;Jiachuan [2]Duan;Qiyong [3]Gong;Xiaoqi [3]Huang;Hongxia [2]Li;Li [2]Wang;Jingqiu [4]Cheng 高影响力作者 机构地区：[1]Department of Neurology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China;[2]National Chengdu Center for Safety Evaluation of Traditional Chinese Medicine, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China;[3]Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China;[4]Laboratory of Transplant Engineering and Immunology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China高影响力机构 出　　处：《Neural Regeneration Research》索引2010年第5卷第15期,共5页高影响力期刊 基　　金：the National High Technology Program of China,No.2006AA02A117 摘　　要：Nonhuman primates are closest to humans in terms of lineage,and middle cerebral artery ischemia/reperfusion responses of nonhuman primates are most similar to ischemic stroke in humans.Therefore,nonhuman primates could be utilized to simulate the process of ischemic stroke in the human.Few studies,however,have reported the use of endovascular technology to establish a rhesus monkey stroke model.In the present study,seven adult,male,rhesus monkeys were selected and,following anesthesia,a microcatheter was inserted into one side of the middle cerebral artery via the femoral artery to block blood flow,thereby resulting in middle cerebral artery occlusion.After 2 hours,the microcatheter was withdrawn to restore the middle cerebral artery blood flow and to establish ischemia/reperfusion.Results from angiography and magnetic resonance angiography confirmed occlusion and reopening of the middle cerebral artery.Magnetic resonance imaging revealed the existence of ischemic brain lesions,and neurological examination showed sustained functional deficits following surgery.The rhesus monkey middle cerebral artery ischemia/reperfusion models established by microcatheter embolization had the advantage of non-craniotomy invasion and reproducibility.The scope and degree of ischemic damage using this model was controllable.Therefore,this nonhuman primate model is an ideal model for cerebral ischemia and reperfusion. 关 键 词：脑缺血再灌注 动物模型 小导管 动脉 大脑 猕猴 缺血/再灌注损伤 非人灵长类动物
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