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“Anti-HBc alone” in human immunodefi ciency virus-positive and immuno-suppressed lymphoma patients

查看全文 作　　者：Yu Xuan [1]Koo;Daniel SW [2]Tan;Iain BH [2]Tan;Richard [2]Quek;Miriam [2]Tao;Soon Thye [2]Lim 高影响力作者 机构地区：[1]Yong Loo Lin School of Medicine,NationalUniversity of Singapore,10 Medical Drive,Singapore 117597,Singapore;[2]Department of Medical Oncology,National Cancer Centre Singapore,11 Hospital Drive,Singapore 169610,Singapore高影响力机构 出　　处：《World Journal of Gastroenterology》索引2009年第15卷第30期,共2页高影响力期刊 摘　　要：Hepatitis B virus (HBV) infection is endemic in various parts of the world. A proportion of patients have resolved prior exposure to HBV, as evidenced by the clearance of circulating hepatitis B surface antigen and the appearance of antibody to hepatitis B core antigen (anti-HBc), which could produce protective antibody to hepatitis B surface antigen (anti-HBs). With time, anti-HBs in some patients may become negative. Such patients are described as having occult HBV infection or 'anti-HBc alone'. In the context of immunodef icient patients, such as HIV patients or lymphoma patients undergoing immunosuppressive immunotherapy, the lack of protective anti-HBs may increase the risk of hepatitis B reactivation. Serum HBV DNA testing may be necessary in 'anti-HBc alone' patients, to detect patients at a high risk of developing HBV infection allowing appropriate prophylactic management. 关 键 词：人类免疫缺陷病毒 免疫反应 HBC 淋巴瘤 患者 阳性 乙型肝炎表面抗原 乙型肝炎病毒
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