Scanning for signatures of geographically restricted selection based on population genomics analysis

查看全文 作　　者：DENG [1,2]LiBin;TANG [1]XiaoLi;KANG [3]Jian;WANG [4]QingYun;ZENG [1]ChangQing

机构地区：[1]Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101300, China;[2]Graduate University of Chinese Academy of Sciences, Beijing 100049, China;[3]Department of Mathematical Sciences, School of Science, Tsinghua University, Beijing 100084, China;[4]School of Mathematical Sciences, Beijing Normal University, Beijing 100875, China

出　　处：《Chinese Science Bulletin》索引2007年第52卷第19期,共8页

摘　　要：Natural selection, as the driving force of human evolution, has direct impact on population differentiation. However, it is still unclear to what extent the genetic differentiation has been caused by natural selection. To explore this question, we performed a genome-wide scan with single nucleotide polymorphism (SNP) data from the International HapMap Project. Single locus FST analysis was applied to assess the frequency difference among populations in autosomes. Based on the empirical distribution of FST, we identified 12669 SNPs correlating to population differentiation and 1853 candidate genes subjected to geographic restricted natural selection. Further interpretation of gene ontogeny revealed 121 categories of biological process with the enrichments of candidate genes. Our results suggest that natural selection may play an important role in human population differentiation. In addition, our analysis provides new clues as well as research methods for our understanding of population differentiation and natural selection. 关键词：单核苷酸基因多态性染色体扫描技术

相关文献

参考文献（10）
引证文献（3）
耦合文献（0）

参考文献(10)

引证文献(3)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Scanning for signatures of geographically restricted selection based on population genomics analysis

参考文献(10)

引证文献(3)

用户提示