维普中文期刊产品整合服务

Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma

查看全文 作　　者：Dénes Gr[1]g;János Regly-[2]Mérei;Sándor [3]Paku;László [4]Kopper;Péter [4]Nagy 高影响力作者 机构地区：[1]Department of Transplantation and SurgerySemmelweis University,Budapest,Hungary;[2]Third Department of SurgerySemmelweis University,Budapest,Hungary;[3]Joint Research Organization of the Hungarian Academy of Sciences and Semmelweis UniversityBudapest,Hungary;[4]First Department of Pathology and Experimental Cancer ResearchSemmelweis University,Budapest,Hungary高影响力机构 出　　处：《World Journal of Gastroenterology》索引2005年第11卷第32期,共4页高影响力期刊 基　　金：Supported by the National Science Foundation of Hungary, No.OTKA 42674 摘　　要：AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples.METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens: AFP, β-catenin, p53, CD44, MSH-2,MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups.RESULTS: Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nuclear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples.CONCLUSION: AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data onin vivo human tumors. 关 键 词：α-胎蛋白 基因表达 压力预兆标记 肝细胞癌 病理机制
相关文献

参考文献(24)

引证文献(6)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费