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Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer

查看全文 作　　者：Eeva [1]Salminen;Salla [1]Palmu;Tero [2]Vahlberg;Peter [3]J.Roberts;Karl-Owe S(o|¨)derstr(o|¨)[4]m 高影响力作者 机构地区：[1]Department of Oncology and Radiotherapy Turku University Hospital, 20510 Turku, Finland;[2]Department of Biostatistics University of Turku,20510 Turku,Finland;[3]Department of Surgery Turku University Hospital, 20510 Turku, Finland;[4]Department of Pathology Turku University Hospital, 20510 Turku,Finland高影响力机构 出　　处：《World Journal of Gastroenterology》索引2005年第11卷第21期,共5页高影响力期刊 基　　金：Supported by the Emil Aaltonen Foundation and Turku University Research Foundation 摘　　要：AIM: To assess the expression of Ki67 as prognosticator in rectal/recto sigmoid cancer.METHODS: Samples from 146 patients with rectal and recto sigmoid cancer were studied for expression of Ki67 and its prognostic significance in comparison with clinicopathological predictors of survival. Formalin-fixed, paraffin-embedded tissues from 6 (4.1%) patients with T1, 26 (17.8%) with T2, 94 (64.4%) with T3, and 20 (13.7%) with T4 tumors were studied. Ki67 expression was determined immunohistochemically. Samples were divided according to mean value into high (>40%) and low (≤40%) expression. Areas of extensive proliferation (>50%) were defined as 'hot spot' areas. RESULTS: Hot spot areas were present in samples regardless of histopathological grade. Lower TNM and Dukes stage and higher expression of Ki67 and presence of Ki67 hot spot areas in histopathological samples were associated with better survival, whereas no association was observed with histopathological grade (P = 0.78). In Cox multivariate regression analysis, significant prognostic factors were Dukes stage (P<0.001), presence of lymph node metastases (P = 0.015), age (P = 0.035) andpresence of Ki67 hot spot areas (P = 0.044). CONCLUSION: Proliferative activity as measured by Ki67 in rectal cancer is associated with survival improvement compared with patients with low Ki67. Areas of prognostically significant increased proliferation were found independently of histopathological tumor grade. 关 键 词：细胞增殖 增殖活性 免疫反应性 KI67 直肠S形肿瘤
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