Radiation-induced meningiomas: clinical, pathological, cytokinetic, and cytogenetic characteristics(英文)

查看全文 作　　者：Al-Mefty [1]O;Topsakal [1]C;Pravdenkova [1]S;Sawyer [1]JR;Harrison [1]MJ 机构地区：[1]University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA. 出　　处：《中国神经肿瘤杂志》索引2004年第2卷第2期,共1页 摘　　要：OBJECTIVE: Radiation-induced meningiomas are known to occur after high and low-dose cranial radiation therapy. The goal of this study was to discern the distinguishing findings and characteristics of radiation-induced meningiomas. METHODS: The records of 16 patients (seven men and nine women) who fulfilled the criteria for radiation-induced meningiomas were retrospectively reviewed.Clinical, histopathological, cytokinetic,and cytogenetic findings as well as the patients' outcome were analyzed. The mean age of the patients was 38.8 years and the mean tumor latency was 26. 5 years. Five patients had multiple meningiomas in the irradiated field. The recurrence rate was 100% after the initial resection; 62% of patients had a second recurrence and 17% had a third recurrence. Thirtyeight percent of patients had atypical or malignant histopathological findings. The presence of progesterone receptors and low 关 键 词：放射性脑膜瘤 病理学 细胞动力学 细胞生成