Perspectives of DNA microarray and next-generation DNA sequencing technologies

查看全文 作　　者：TENG XiaoKun1 & XIAO HuaSheng1,2 1 National Engineering Center for Biochip at Shanghai,Shanghai 201203,China 2 Shanghai-MOST Key Laboratory of Health and Disease Genomics,Chinese National Human Genome Center,Shanghai 201203,China

出　　处：《Science China(Life Sciences)》索引2009年第52卷第1期,共10页

基　　金：Supported by the National High-Tech Research Program of China (Grant No.2006AA020704);Shanghai Science and Technology Commission (Grant No.05DZ22201) 摘　　要：DNA microarray and next-generation DNA sequencing technologies are important tools for high-throughput genome research,in revealing both the structural and functional characteristics of genomes.In the past decade the DNA microarray technologies have been widely applied in the studies of functional genomics,systems biology and pharmacogenomics.The next-generation DNA sequencing method was first introduced by the 454 Company in 2003,immediately followed by the establishment of the Solexa and Solid techniques by other biotech companies.Though it has not been long since the first emergence of this technology,with the fast and impressive improvement,the application of this technology has extended to almost all fields of genomics research,as a rival challenging the existing DNA microarray technology.This paper briefly reviews the working principles of these two technologies as well as their application and perspectives in genome research. 关键词：DNA MICROARRAY next generation DNA SEQUENCING genome

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Perspectives of DNA microarray and next-generation DNA sequencing technologies

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