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| 1 | Immunoregulatory effects of Tripterygium wilfordii Hook Fand its extracts in clinical practice显示文摘Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of T and B cells;ratio of T cell subsets;inflammatory response of monocytes, macrophages, and immunoglobulins;and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation. | Dan Luo Zhengyun Zuo Hongyan Zhao Yong Tan Cheng Xiao | 2019 | Frontiers of Medicine2019，13，5： | 19 |
| 2 | Organic anion transporter 1 and 3 contribute to traditional Chinese medicine-induced nephrotoxicity显示文摘With the internationally growing popularity of traditional Chinese medicine(TCM), TCM-induced nephropathy has attracted public attention. Minimizing this toxicity is an important issue for future research. Typical nephrotoxic TCM drugs such as Aristolochic acid, Tripterygium wilfordii Hook. f, Rheum officinale Baill, and cinnabar mainly damage renal proximal tubules or cause interstitial nephritis. Transporters in renal proximal tubule are believed to be critical in the disposition of xenobiotics. In this review, we provide information on the alteration of renal transporters by nephrotoxic TCMs, which may be helpful for understanding the nephrotoxic mechanism of TCMs and reducing adverse effects. Studies have proven that when administering nephrotoxic TCMs, the expression or function of renal transporters is altered, especially organic anion transporter 1 and 3. The alteration of these transporters may enhance the accumulation of toxic drugs or the dysfunction of endogenous toxins and subsequently sensitize the kidney to injury.Transporters-related drug combination and clinical biomarkers supervision to avoid the risk of future toxicity are proposed. | SHEN Qing-Qing WANG Jing-Jing ROY Debmalya SUN Li-Xin JIANG Zhen-Zhou ZHANG Lu-Yong HUANG Xin | 2020 | Chinese Journal of Natural Medicines2020，18，3： | 11 |
| 3 | Triptolide, A Potential Autophagy Modulator显示文摘As a major active component extracted from traditional Chinese herb Tripterygium wilfordii Hook F, triptolide exhibits multiple pharmacological effects. Autophagy is an evolutionary conserved intracellular catabolic process involved in cytoplasmic materials degradation. Autophagic dysfunction contributes to the pathologies of many human diseases, which makes it a promising therapeutic target. Recent studies have shown that triptolide exerts neuroprotection, anti-tumor activities, organ toxicity, and podocyte protection by modulating autophagy. This article highlights the current information on triptolide-modulated autophagy, analyzes the possible pathways involved, and describes the crosstalk between autophagy and apoptosis modulated by triptolide, in hope of providing implications for the roles of autophagy in pharmacological effects of triptolide and expanding its novel usage as an autophagy modulator. | WEI Yan-ming WANG Yong-hui XUE Hui-qing LUAN Zhi-hua LIU Bi-wang REN Jin-hong | 2019 | Chinese Journal of Integrative Medicine2019，25，3： | 10 |
| 4 | Benefits and Safety of Tripterygium Glycosides and Total Glucosides of Paeony for Rheumatoid Arthritis: An Overview of Systematic Reviews显示文摘Objective: To summarize the evidence from systematic reviews(SRs) on the benefits and safety of Tripterygium glycosides(TG) and total glucosides of paeony(TGP), commonly used to treat rheumatoid arthritis(RA) in China, for patients with RA. Methods: SRs of randomized controlled trials(RCTs) on TG or TGP in treating RA were included, by searching 8 databases from their inception until December 2017. Two authors extracted data independently. We assessed the quality of SRs using AMSTAR and graded the quality of evidence according to the GRADE approach. Results: Eleven SRs containing an average of 7.6 RCTs, involving a total of 7,012 participants were included in this overview. On the basis of included SRs, TG and TGP could improve the following indexes for RA patients: American College of Rheumatology(ACR) 20 response rate, ACR50 response rate and ACR70 response rate, swollen joint count, tender joint count, erythrocyte sedimentation rate and C-reactive protein. Moreover, TGP could reduce incidence of hepatotoxicity. The most common adverse effects of TG were gastrointestinal discomfort and gonad toxicity, while for TGP was mild to moderate diarrhea. The overall quality of evidence for these findings ranged from 'low' to 'moderate'. Conclusions: TG and TGP might be 2 potentially effective complementary and alternative drugs for patients with RA. Nevertheless, due to gonad toxicity, TG should only be considered in elderly patients or patients without reproductive needs. More evidence from high quality RCTs and SRs is warranted to support the use of TG and TGP for RA patients. | LUO Jing SONG Wei-jiang XU Yuan CHEN Guang-yao HU Qi TAO Qing-wen | 2019 | Chinese Journal of Integrative Medicine2019，25，9： | 8 |
| 5 | Effects of adding tripterygium glycosides to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on albuminuria in patients with diabetic nephropathy显示文摘Introduction::Tripterygium glycosides (TGs) have been widely used in China to treat diabetic nephropathy (DN);however, proof of their use is scarce. The present study aimed to evaluate the effectiveness and safety of adding TGs to angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs).Methods::By searching Embase, MEDLINE, Cochrane Library, SINOMED, China National Knowledge Infrastructure, VIP Information/Chinese Scientific Journals, and WANFANG databases, we identified previous studies that met the specific selection criteria and included them in the meta-analysis. Analyses were performed using Review Manager (version 5.3).Results::Nine randomized controlled trials were included in the final meta-analysis. Patients were compared before and after treatment with ACE inhibitors or ARBs plus TGs, or ACE inhibitors or ARBs alone. The results revealed that treatment with ACE inhibitors or ARBs plus TGs resulted in significantly greater reductions in 24-h urinary total protein (UTP) levels (trial duration <2 months, mean difference [MD]: -0.25;95% confidence interval [ CI]: -0.32, -0.18;trial duration between 2 and 6 months, MD: -0.39;95% CI: -0.44, -0.33;trial duration >6 months, MD: -2.09;95% CI: -2.89, -1.29) compared with treatment using ACE inhibitors or ARBs alone. Additionally, ACE inhibitors or ARBs plus TGs showed better results after longterm administration. Treatment with ACE inhibitors or ARBs plus TGs resulted in significantly greater reductions in serum creatinine (SCr) compared with ACE inhibitors or ARBs alone (MD: -9.87;95% CI: -13.76, -5.97). Conclusion::In patients with DN, adding TGs to ACE inhibitors or ARBs significantly lowered both the 24-h UTP and SCr levels. Therefore, ACE inhibitors or ARBs plus TGs might improve the treatment of DN in patients. | Fang Jin-Ying Yang Yue Zhang Zheng Jiang Shi-Min Yu Tian-Yu Li Wen-Ge | 2020 | Chronic Diseases and Translational Medicine2020，6，1： | 8 |
| 6 | Effect of cream, prepared with Tripterygium wilfordii Hook F and other four medicinals, on joint pain and swelling in patients with rheumatoid arthritis: a double-blinded, randomized, placebo controlled clinical trial显示文摘OBJECTIVE: To investigate the effectiveness a cream onjoint pain and swelling in patients with rheumatoid arthritis(RA). The cream, topically used, in was prepared with Tripterygium wilfordii Hook F(TwHF), Mangxiao(Nalrii Sulfas), Chuanxiong(Rhizoma Chuanxiong), stir-frying with liquid adjuvant Ruxiang(Olibanum), and stir-frying with liquid adjuvant Moyao(Myrrh).METHODS: Patients were 1∶1 randomized to addon TwHF cream twice a day or placebo for 4 weeks.The primary endpoint was achievement rate of20% improvement in American College of Rheuma-tology criteria(ACR20) at week 4. Secondary endpoints were ACR50, 28-joint count Disease Activity Score(DAS28) improvement and safety profiles.Statistical analyses were performed using intention to treat analysis(ITT) set.RESULTS: A total of 70 active RA patients were enrolled. At week 4, the ACR20 was 34.3%(12/35) in TwHF cream group and 11.4%(4/35) in placebo group(P = 0.015). Similarly, a higher ACR50 responder proportion was seen in TwHF cream group with 17.1%(6/35) comparing to it in placebo group with 2.9%(1/35)(P = 0.046). The TwHF cream group also had more improvement than the placebo group on DAS28-ESR(1.1 vs 0.5, P = 0.001), DAS28-CRP(1.4 vs 0.7, P = 0.001), tender joint count(5.5 vs2.6, P = 0.018), swollen joint count(3.5 vs 1.6, P =0.003) and Physician's global assessment(25.8 vs13.0, P = 0.002), as well as C-reactive protein(11.2 vs 2.7, P = 0.048). Except 2 skin allergy events in TwHF cream group, no other substantive adverse events were observed.CONCLUSION: On the short term, TwHF cream is likely to be an effective and safety complimentary treatment in patients with active RA. | Jiao Juan Wei Chengchung Tang Xiaopo Gong Xun Yin Haibo Jiang Quan | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 6 |
| 7 | 火把花根片治疗类风湿性关节炎12例疗效观察显示文摘火把花根片是以卫矛科雷公藤属植物昆明山海棠[Tripterygium hypoglaucum(Levl)Hutch]去皮的根心制备。我所药理研究证明其具有显著的抗炎作用和免疫抑制效果,临床治疗慢性肾炎疗效颇为满意,总有效率为87.12%。我们将其治疗类风湿性关节炎也获满意疗效,兹简介如下。 一、病例选择:凡符合下列4项以上者即列为本组治疗观察对象:1.慢性进行性或游走性多关节疼痛,病程在三个月以上;2.关节肿胀,尤其是对称性小关节肿胀,如梭形指;3.关节晨僵,关节功能受限或障碍;4.关节畸形,尤其是掌指关节尺侧偏向畸形,或指(趾)关节过屈、过伸;5.类风湿因子(RF)试验阳性,或血沉增快;6.X线表现符合类风湿性关节炎改变。本组12例,年龄20~60岁者11例,病程1~10年以上,平均69.5月。 二、药物及用法:火把花根片由四川省中药研究所制药厂生产。每片0.2g,相当于生药2g。每次口服1~2片,一日3次,30天一疗程。 | 张忠祥 马朝俊 | 1990 | 中药药理与临床1990，6，5： | 5 |
| 8 | Effects of Huatan Tongluo decoction on vascular endothelial growth factor receptor 2 expression in synovial tissues of rats with collagen-induced arthritis显示文摘OBJECTIVE: To determine the therapeutic effect and potential mechanism of Huatan Tongluo decoction on rats with collagen-induced arthritis.METHODS: Forty specific pathogen-free Wistar rats were selected, and 10 were randomly selected as the control(group 1). The remaining rats were injected intradermally with emulsified type Ⅱ bovine collagen at the tail base and back, followed by a booster 7 d post first immunization. After establishing collagen-induced arthritis(CIA), rats were randomly divided into three groups(n = 10). The rats were treated orally for 30 d as follows: group 1, saline; group 2, model(saline); group 3, tripterygium polyglycoside(TP; 7.81 mg/kg, positive control);group 4, Huatan Tongluo decoction(HTTL; 7.5 g/kg). Body weight, ankle swelling and arthritis index were measured over the course of the study. The rats were sacrificed 30 d after treatment. Morphological changes in the synovium were observed by hematoxylin and eosin staining. Pannus formation and synovial thickness in the left ankle were observed by color Doppler ultrasoundVascular endothelial growth factor(VEGF) and VEGFR2 protein levels were measured by immunohistochemistry.VEGF/VEGFR2 mRNA levels were measured by real-time quantitative polymerase chain reaction.RESULTS: Compared with the model group, a significantly lower arthritis index was observed in the positive control group(P < 0.05) and HTTL group(P < 0.01), after treatment. Both positive control and HTTL reduced intra-articular pannus formation and synovial thickening. Furthermore, VEGF mRNA,and VEGFR2 protein and mRNA levels were significantly downregulated(P < 0.05) in the treatment groups.CONCLUSION: Inhibition of the expression of VEGF and VEGFR2 in synovial tissues and the formation of pannus and synovial hyperplasia may be part of the mechanism of HTTL for relieving the symptoms of rheumatoid arthritis in CIA rats. | Chen Jinchun Qiu Mingshan Li Yihan Zhang Qian Zhang Yiyan Lin Shuangjie Zhang Shaohong Qian Lixia Gao Hai Li Liang-cheng | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 4 |
| 9 | The Effects of Lei Gong Teng on Reproductive Hormones显示文摘The serum reproductive hormone levels were examined with radioimmunoassay in women of child-bearing age before and after treatment with the prescriptions containing Lei Gong Teng (雷公藤Radix Tripterygii Wilfordii). The results showed that Lei Gong Teng could induce amenorrhea, but it was reversible. | 顾江红 朱彩凤 王蔚 王联欢 缪卫群 | 2001 | Journal of Traditional Chinese Medicine2001，21，1： | 3 |
| 10 | Decreased bone mineral density in female patients with systemic lupus erythematosus after long term administration of Tripterygium Wilfordii Hook F显示文摘Objective To investigate the possible bone changes in female patients with systemic lupus erythematosus (SLE) induced by long term administration of Tripterygium Wilfordii Hook F (TW) Methods 70 female SLE patients were divided into 4 groups accordiog to their drug history: SLE disease control group, corticosteroids treatment group, TW treatment group, and both corticosteroids and TW treatment group Bone mineral density (BMD) of the lumbar spine 2-4 and biochemical markers of bone turnover were studied Results Long term administration of TW could significantly decrease BMD levels in female SLE patients ( P <0 05) The patients receiving TW for more than 5 years had significantly lower BMD levels compared with those for less than 5 years The degree of decreased BMD induced by TW was less severe compared with that of prednisone No significant differences were observed in the biochemical markers of bone turnover among four groups ( P >0 05) Conclusion Long term administration of TW could decrease BMD levels in women Osteoporosis may be an important problem for SLE patients treated with | 黄岚 冯树芳 王洪复 | 2000 | Chinese Medical Journal2000，，2： | 3 |
| 11 | A NEW DITERPENE LACTONE FROM TRIPTERYGIUM WILFORDII显示文摘A new diterpene lactone with an ent--kaurane skeleton, named antriptolactone(1)was isolated from the roots of Tripterygium wilfordii cellected in Anhui province. Its structurewas elucidated by spectral data and chemical transformtion. | De Quan YU Feng Zhi XIE Xiao Tian LIANG Institute of Mateia Medica, Chinese Academy of Medial Sciences, Beijeng, 100050 | 1992 | Chinese Chemical Letters1992，3，6： | 3 |
| 12 | Combination therapy of tripterygium glycosides plus valsartan in diabetic nephropathy treatment: A systematic review and meta-analysis显示文摘Objective: To assess the efficacy and safety of the combination therapy of Chinese herbal medicines,tripterygium glycosides, plus valsartan for the treatment of diabetic nephropathy(DN).Methods: A comprehensive research of 12 electronic databases was performed. Data of the included studies were extracted and analyzed independently by two authors, and were synthesized using Review Manager(version 5.2) and Stata(version 12.0).Results: A total of 12 randomized controlled trials(RCTs) involving 829 patients were included. Pooled results showed that the combination therapy significantly increased total efficacy of DN patients [RR = 1.35,95% CI(1.22, 1.50), P < 0.001], the level of serum albumin [Mean difference(MD)= 3.87, 95% CI(3.12,4.62), P < 0.001], and significantly decreased 24 h urinary protein level [MD =-0.97, 95% CI(-1.19,-0.76), P < 0.001], urinary albumin-excretion rate [MD =-145.53, 95% CI(-227.95,-63.11), P < 0.001],and urinary β2-microglobuli level [MD =-11.86, 95% CI(-13.02,-10.69), P < 0.001]. No significant differences were found in levels of serum creatinine [MD =-0.26, 95% CI(-7.52, 7.00), P > 0.05), blood urea nitrogen [MD = 0.25, 95% CI(-0.23, 0.74), P > 0.05], and endogenous creatinine clearance rate[MD =-0.43, 95% CI(-3.48, 2.62), P > 0.05]. However, tripterygium glycosides plus valsartan seemed to exert higher adverse reaction rate than valsartan monotherapy [MD = 3.41, 95% CI(1.34, 8.66), P < 0.05].There were no publication bias for all of the pooled effect sizes.Conclusion: Combination therapy of tripterygium glycosides plus valsartan may be effective for the treatment of DN. However, the safety of the combination therapy need to be further confirmed. | Wan-chun Ye Jian-zhong Ye Cheng Zheng Xiao-wei He Jia-jie Huang Ren Ye | 2019 | Chinese Herbal Medicines2019，11，2： | 3 |
| 13 | Effect of Tripterygium Vilfordii on Adrenal Cortex in Rat with Adjuvant Arthritis显示文摘(张明敏)(刘沛霖)(叶望云)EffectofTripterygiumVilfordiionAdrenalCortexinRatwithAdjuvantArthritis￥ZHANGMing-min;LIUPei-lin;YEWang-yun(Tongji... | 张明敏 刘沛霖 叶望云 | 1994 | Journal of Huazhong University of Science and Technology(Medical Sciences)1994，14，3： | 2 |
| 14 | 雷公藤贴膏外用治疗类风湿性关节炎的初步观察显示文摘近年来,雷公藤(Tripterygium wilforclii Hookiff)治疗类风湿性关节炎(RA)取得显著疗效,口服制剂使用居多,而外用制剂尚未见报告,现将我院用雷公藤贴膏外用治疗RA的初步观察报告如下。 临床资料 一、病例选择:均按美国风湿病协会(ARA)标准诊断为典型或肯定的RA,分期按湖北省雷公藤治疗类风湿性关节炎协作组制定的标准。 二、一般资料:共22例,男11例,女11例。 | 李瑞林 | 1989 | 中药药理与临床1989，5，6： | 2 |
| 15 | Animal-mediated long-distance dispersals and migrations shaping the intercontinental disjunctions of Celastrus(Celastraceae)among five continents显示文摘The mechanisms underlying the origin,evolution,and distributional patterns of organisms are a major focus of biogeography.Vicariance and long-distance dispersal(LDD)are two important explanations for disjunctive distribution patterns among lineages.In-depth biogeographic studies of taxa that exhibit wide-ranging disjunctions can provide valuable information for addressing the relative importance of these biogeographic mechanisms.The genus Celastrus contains ca.30 species that are disjunctly distributed in five continents of both the Northern and Southern Hemispheres,providing an excellent system for historical biogeographic analyses.Here,we used sequence data from five markers(nuclear external transcribed spacer and internal transcribed spacer,and plastid psbA-trnH,rpl16,and trnL-F)to reconstruct the phylogeny of Celastrus and investigate its phylogenetic relationships with Tripterygium,estimate clade divergence times using the fossil-calibrated method,and infer its ancestral distribution range.Celastrus and Tripterygium were each supported as monophyletic.The morphology-based classification systems were not supported by the phylogenetic results.The divergence time between Celastrus and Tripterygium was estimated to be 26.22 Ma(95%highest posterior density:24.46-28.17 Ma),and the diversification of Celastrus were suggested to be linked to global warming events during the Miocene.Celastrus was suggested to have a tropical Asian origin,and dispersed to Central and South America,North America,Oceania,and Madagascar at different periods,most probably through LDD.Birds may have facilitated transoceanic migrations of Celastrus because of its bicolored fruits,which contain red and fleshy arils.Our results highlight the importance of key morphological innovations and animal-mediated dispersals for the rapid diversification of plant lineages across vast distributional ranges. | Yi-Xuan Zhu Feng-Wei Lei Ling Tong Xian-Yun Mu Jun Wen Zhi-Xiang Zhang | 2020 | Journal of Systematics and Evolution2020，58，6： | 1 |
| 16 | Efficacy of Bushen Culuan decoction(补肾促卵方)on ovarian follicle and follicular granulosa cells in mice with premature ovarian insufficiency induced by tripterygium wilfordii polyglycoside显示文摘OBJECTIVE:To investigate the protective efficacy of Bushen Culuan decoction补肾促卵方,BCD)on ovarian follicle and follicular granulosa cells in mice with premature ovarian insufficiency(POI)induced by tripterygium wilfordii polyglycoside,and to study the potential mechanism underlying the action.METHODS:Eighty female Balb/c mice were randomly divided into 4 groups(n=20 each):blank group,model group,Bushen Culuan decoction intervening group(BCD group)and estradiol valerate intervening group(EV group).In the first 14 model establishing d,mice in model group,BCD group and EV group were under Tripterygium wilfordii polyglycoside(TWP)gavage to establish POI models.In the 14-day therapeutic stage,mice in BCD group were taken BCD 18.35 mg·kg^(-1)·d^(-1),mice in EV group were taken EV solution 0.15 mg·kg^(-1)·d^(-1),while mice in blank group and model group were taken normal saline.When the mice accomplished therapy,whole blood was collected for serum hormone including follicle stimulating hormone(FSH),luteal hormone(LH),estradiol(E2),antimullerian hormone(AMH)levels and vascular endothelial growth factor(VEGF),bone morphogenetic protein-7(BMP-7)measurement.Ovarian tissues were harvested for morphologic observation,follicle counting,ovarian follicular graulosa cell apoptosis test and testing BMP-7 and caspase-3 expressions.RESULTS:The body weights of the mice kept growing stably in the process expect in TWP intervening stage.Compared with model group,BCD group had significantly higher ovarian index,serum E_(2),AMH,VEGF,BMP-7 levels and significantly lower FSH level(P<0.05).Meanwhile the VEGF level in BCD group was higher than in EV group(P<0.05).Compared with model group,the histopathological damage and GCs apoptosis were mitigated;developing follicle counting,BMP-7 expression were up-regulated,and caspase-3 expression was downregulated in BCD groups(P<0.05).CONCLUSION:BCD treatment could attenuate pathological process in POI ovaries,suppress GC apoptosis,probably through promoting BMP-7 expression and following inhibiting caspase-3 activation. | MA Kun YUAN Yuan CHEN Yanxia YUAN Bochao WANG Kaili TIAN Caidie LI Jiani | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 1 |
| 17 | Tripterygium wilfordii Hook F is efficacious in the treatment of Henoch-Schönlein purpura nephritis in children显示文摘I read with interest the recently published article by Huang et al.[1]The article is very informative and has brought an utmost important insight on chronic glomerulonephritis in children.It is an interesting issue,because glomerulonephritis such as Schonlein-Henoch nephritis(HSPN)may lead to renal failure in children and adolescents.The well-presented clinical features and histopathological changes described in the article are valuable for pediatricians in diagnosing HSPN in the high-risk population. | Shu-Jiong Mao Xian-Mei Huang | 2016 | World Journal of Pediatrics2016，12，3： | 1 |
| 18 | ULTRASTRUCTURAL OBSERVATION ON MACROPHAGE-LYMPHOCYTE INTERACTIONS IN SEMEN FROM TRIPTERYGIUM WILFORDII HOOK.F. TAKERS显示文摘Sixty-nine specimens from Tripterygium Wilfordii Hook.f. (TWH) users were investigated by electron microscopy. No macrophages were demonstrated in the 21 specimens collected prior to the administration of TWH. However, it was found in 23 out of the 48 semen specimens obtained following the TWH administration. The macrophages were functionally active as shown by the presence of a large number of cytoplasmic processes and pseudopodia on the surface, and primary and secondary lysosomes in the cytoplasm. The macrophages phagocytized sperm debris and degenerated or dead spermatids with formation of specific phagosomes. Around those macrophages, lymphocytes were commonly noted. The cytoplasmic processes of the two cell types could come into contact or even fuse with each other, leading to tight junction-like structure; in some of the contacts, the plasma membranes were found dissolved so as to form direct cytoplasmic linkage. | 贾太和 孙辉臣 王晓旭 修贺明 丁卫东 郝晓东 武丽 王更新 雷建章 | 1994 | Chinese Medical Journal1994，，12： | 1 |
| 19 | 中药对抗雷公藤副作用的临床观察显示文摘雷公藤(Tripterygium wilfordii Hook)是著名的毒性药物,该药的副作用已有专门论述。但至今尚未见到有关对抗其副作用的报道。笔者于1991年6月~1992年2月,用本所研制的“消风病”——雷公藤醋酸乙酯提取物片。(每片含提取物20mg)治疗类风湿性关节炎门诊病人55例,取得了满意的效果,同时对在治疗过程中出现的副作用进行了观察,并根据中医辨证,选用中药以对抗之,现将初步结果报告如下。 | 胡祖光 刘惠纯 张天喜 | 1992 | 中药药理与临床1992，8，5： | 1 |
| 20 | LOW-DOSE CYCLOSPORIN A AND TRIPTERYGIUM WOLFORDII INHIBITED PORCINE INTESTINAL ALLOGRAFT REJECTION显示文摘The aim of this study was to evaluate whether Tripterygium wolfordii(TW) could be used as an inamunosuppressant,and whether antirejection therapy with low-dose cyclosporin A(CsA) alone in intestinal transplentation in pigs. | 廖彩仙 黎介寿 | 1994 | Chinese Medical Journal1994，，9： | 0 |
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