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| 1 | DNA条形码在新型毒品原植物恰特草种属鉴定中的应用研究显示文摘毒品原植物是指用来提炼、加工成鸦片、海洛因、甲基苯丙胺、吗啡等麻醉药物和精神药物的原植物。其中罂粟、古柯、大麻被称为世界三大毒品原植物。恰特草作为一种新型毒品原植物近两年被大量走私入境。 | 申钰柯 刘陈业 周旦 陈鹏升 陈云霞 | 2017 | 森林公安2017，0，3： | 4 |
| 2 | Leigongteng(Radix et Rhizoma Tripterygii) via compatibility with Jinqiancao(Herba Lysimachiae): its toxicity-reduced efficacy in H22-bearing mice显示文摘OBJECTIVE: To observe toxicity-reduced effects of Leigongteng(Radix et Rhizoma Tripterygii)(LGT) via compatibility with Jinqiancao(Herba Lysimachiae)(JQC) in H22-bearing mice and investigate the possible underlying mechanism, and further explore whether JQC can enhance LGT-evoked anti-tumor effect.METHODS: H22-bearing mice were orally administered with LGT alone and its compatibility with JQC, and tumors, serum, livers and kidneys were collected to evaluate the toxicity-reduced efficacy and the possible mechanism.RESULTS: LGT evoked significantly elevated biochemical indicators including serum alanine/aspartate transaminase(ALT/AST), creatinine(Cr) and urea nitrogen(BUN) as well as pathological damage in mice, which were all obviously reversed by JQC via compatibility at the ratios from 4/1 to 1/4.Further analysis indicated that pro-inflammatory cytokine tumor necrosis factor-alpha(TNF-α), and malondialdehyde(MDA) levels significantly decreased, while anti-inflammatory cytokine interleukin(IL)-10, and glutathione(GSH), GSH-s transferase(GST), GSH peroxidase(GSH-Px), superoxide dismutase(SOD) and catalase(CAT) levels all increased in livers and kidneys of mice. Besides, after compatibility with JQC at the ratios of 4/1, 2/1, 1/1,1/2 and 1/4, LGT-decreased tumor weight was further decreased by 48.4%, 57.3%, 54.0%, 49.3% and52.9%, respectively(all P < 0.01).CONCLUSION: JQC could reduce LGT-induced hepatotoxicity and nephrotoxicity, and enhance the antitumor efficacy via compatibility with JQC, and the toxicity-reduced mechanism could involve inhibiting hepatic and kidney oxidative stress and inflammation. | Wang Junming Li Jinhua Cai Hong Zhang Yueyue Li Jinyang Cui Ying | 2019 | Journal of Traditional Chinese Medicine2019，39，4： | 2 |
| 3 | Animal-mediated long-distance dispersals and migrations shaping the intercontinental disjunctions of Celastrus(Celastraceae)among five continents显示文摘The mechanisms underlying the origin,evolution,and distributional patterns of organisms are a major focus of biogeography.Vicariance and long-distance dispersal(LDD)are two important explanations for disjunctive distribution patterns among lineages.In-depth biogeographic studies of taxa that exhibit wide-ranging disjunctions can provide valuable information for addressing the relative importance of these biogeographic mechanisms.The genus Celastrus contains ca.30 species that are disjunctly distributed in five continents of both the Northern and Southern Hemispheres,providing an excellent system for historical biogeographic analyses.Here,we used sequence data from five markers(nuclear external transcribed spacer and internal transcribed spacer,and plastid psbA-trnH,rpl16,and trnL-F)to reconstruct the phylogeny of Celastrus and investigate its phylogenetic relationships with Tripterygium,estimate clade divergence times using the fossil-calibrated method,and infer its ancestral distribution range.Celastrus and Tripterygium were each supported as monophyletic.The morphology-based classification systems were not supported by the phylogenetic results.The divergence time between Celastrus and Tripterygium was estimated to be 26.22 Ma(95%highest posterior density:24.46-28.17 Ma),and the diversification of Celastrus were suggested to be linked to global warming events during the Miocene.Celastrus was suggested to have a tropical Asian origin,and dispersed to Central and South America,North America,Oceania,and Madagascar at different periods,most probably through LDD.Birds may have facilitated transoceanic migrations of Celastrus because of its bicolored fruits,which contain red and fleshy arils.Our results highlight the importance of key morphological innovations and animal-mediated dispersals for the rapid diversification of plant lineages across vast distributional ranges. | Yi-Xuan Zhu Feng-Wei Lei Ling Tong Xian-Yun Mu Jun Wen Zhi-Xiang Zhang | 2020 | Journal of Systematics and Evolution2020，58，6： | 1 |
| 4 | Maytenus erythroxylon Reissek(Celastraceae) ethanol extract presents antidiarrheal activity via antimotility and antisecretory mechanisms显示文摘AIM To investigate the acute toxicity,phytochemical profile,antidiarrheal activity and mechanisms of action of Maytenus erythroxylon(M.erythroxylon)ethanol extract.METHODS A castor oil-induced diarrhea model was used to evaluate antidiarrheal activity.Intestinal transit and gastric emptying protocols were used to evaluate a possible antimotility effect.KATP channels,nitric oxide,presynapticα2-adrenergic and tissue adrenergic receptors were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory mechanisms.RESULTS All tested doses of the extract(62.5,125,250 and 500 mg/kg)possessed antidiarrheal activity,with a significant decrease of the evacuation index.This activity is possibly related to a reduced gastric emptying(125,250 and 500 mg/kg)and to a decreased percentage of intestinal transit for all tested doses.That last effect seems to be modulated by nitric oxide,KATP channels and tissue adrenergic receptors.Besides,the extract also presented antisecretory effect due to a decrease of intestinal fluid accumulation.CONCLUSION The antidiarrheal effect of M.erythroxylon found in this study involves antimotility and antisecretory mechanisms that may be attributed to the chemical compounds found in this species:saponins,flavonoids,tannins,triterpenes and steroids. | Rodrigo de Oliveira Formiga Zelma Glebya Maciel Quirino Margareth de Fátima Formiga Melo Diniz Alexsandro Fernandes Marinho Josean Fechine Tavares Leonia Maria Batista | 2017 | World Journal of Gastroenterology2017，23，24： | 1 |
| 5 | CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITY OF CELASTRACEAE PLANTS显示文摘Ⅰ. INTRODUCTIONDihydroagarofuran sesquiterpenoids are the main chemical constituents of Celastraceae plants. Since the Celastraceae plants were used as agricultural insecticides, we are quite interested in the investigation on the insecticidal activity of this kind of compound. Our previous note reported that three sesquiterpenoids (1—3) were isolated | 涂永强 吴大刚 | 1992 | Chinese Science Bulletin1992，37，14： | 0 |
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