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| 1 | Microfluidic 3D printing polyhydroxyalkanoates-based bionic skin for wound healing显示文摘Biomimetic scaffolds with extracellular matrix(ECM)-mimicking structure have been widely investigated in wound healing applications,while insufficient mechanical strength and limited biological activity remain major challenges.Here,we present a microfluidic 3D printing biomimetic polyhydroxyalkanoates-based scaffold with excellent mechanical properties and hierarchical porous structures for enhanced wound healing.This scaffold is composed of poly(3-hydroxybutyrate-4-hydroxybutyrate)and polycaprolactone,endowing it with excellent tensile strength(2.99 MPa)and degradability(80%of weight loss within 7 d).The ECM-mimicking hierarchical porous structure allows bone marrow mesenchymal stem cells(BMSCs)and human umbilical vein endothelial cells(HUVECs)to proliferate and adhere on the scaffolds.Besides,anisotropic composite scaffolds loaded with BMSCs and HUVECs can significantly promote re-epithelization,collagen deposition and capillary formation in rat wound defects,indicating their satisfactory in vivo tissue regenerative activity.These results indicate the feasibility of polyhydroxyalkanoates-based biomimetic scaffolds for skin repair and regeneration,which also provide a promising therapeutic strategy in diverse tissue engineering applications. | Wentai Guo Xiaocheng Wang Chaoyu Yang Rongkang Huang Hui Wang Yuanjin Zhao | 2022 | Materials Futures2022，1，1： | 1 |
| 2 | In Situ 3D Bioprinting Living Photosynthetic Scaffolds for Autotrophic Wound Healing显示文摘Three-dimensional(3D)bioprinting has been extensively explored for tissue repair and regeneration,while the insufficient nutrient and oxygen availability in the printed constructs,as well as the lack of adaptive dimensions and shapes,compromises the overall therapeutic efficacy and limits their further application.Herein,inspired by the natural symbiotic relationship between salamanders and algae,we present novel living photosynthetic scaffolds by using an in situ microfluidic-assisted 3D bioprinting strategy for adapting irregular-shaped wounds and promoting their healing.As the oxygenic photosynthesis unicellular microalga(Chlorella pyrenoidosa)was incorporated during 3D printing,the generated scaffolds could produce sustainable oxygen under light illumination,which facilitated the cell proliferation,migration,and differentiation even in hypoxic conditions.Thus,when the living microalgae-laden scaffolds were directly printed into diabetic wounds,they could significantly accelerate the chronic wound closure by alleviating local hypoxia,increasing angiogenesis,and promoting extracellular matrix(ECM)synthesis.These results indicate that the in situ bioprinting of living photosynthetic microalgae offers an effective autotrophic biosystem for promoting wound healing,suggesting a promising therapeutic strategy for diverse tissue engineering applications. | Xiaocheng Wang Chaoyu Yang Yunru Yu Yuanjin Zhao | 2022 | Research2022，，3： | 1 |
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