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| 1 | Nuclear transport proteins: structure, function, and disease relevance显示文摘Proper subcellular localization is crucial for the functioning of biomacromolecules,including proteins and RNAs.Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic compartments.In humans,approximately 60 proteins are involved in nuclear transport,including nucleoporins that form membrane-embedded nuclear pore complexes,karyopherins that transport cargoes through these complexes,and Ran system proteins that ensure directed and rapid transport.Many of these nuclear transport proteins play additional and essential roles in mitosis,biomolecular condensation,and gene transcription.Dysregulation of nuclear transport is linked to major human diseases such as cancer,neurodegenerative diseases,and viral infections.Selinexor(KPT-330),an inhibitor targeting the nuclear export factor XPO1(also known as CRM1),was approved in 2019 to treat two types of blood cancers,and dozens of clinical trials of are ongoing.This review summarizes approximately three decades of research data in this field but focuses on the structure and function of individual nuclear transport proteins from recent studies,providing a cutting-edge and holistic view on the role of nuclear transport proteins in health and disease.In-depth knowledge of this rapidly evolving field has the potential to bring new insights into fundamental biology,pathogenic mechanisms,and therapeutic approaches. | Yang Yang Lu Guo Lin Chen Bo Gong Da Jia Qingxiang Sun | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 1 |
| 2 | 流感病毒跨种传播与感染致病机制研究进展显示文摘A型流行性感冒病毒(influenza A virus,IAV)属于正黏病毒科(Orthomyxoviridae),是单股负链分节段的RNA病毒。IAV基因组由8个节段构成,分别是聚合酶碱性蛋白2(polymerase basic protein 2,PB2)、聚合酶碱性蛋白1(polymerase basic protein 1,PB1)、聚合酶酸性蛋白(polymerase acid protein,PA)、血凝素(hemagglutinin,HA)、核蛋白(nucleoprotein,NP)、神经氨酸酶(neuraminidase,NA)、基质(matrix,M)蛋白和非结构蛋白(nonstructural protein,NS)节段。根据HA和NA的遗传性和抗原性的不同,可以将IAV分为18种HA亚型(H1-H18)和11种NA亚型(N1-N11)。 | 陈化兰 朱启运 徐帅 | 2023 | 兰州大学学报(医学版)2023，49，5： | 0 |
| 3 | A型流感病毒复制过程的研究进展显示文摘流感病毒(Influenza virus)在全球范围内广泛传播,根据其核蛋白(Nucleoprotein,NP)与基质蛋白(Matrix protein,M)抗原性的不同,将流感病毒分为4种类型:A、B、C和D型。每年季节性流行的A型和B型流感病毒(Influenza A and B viruses)感染导致全世界约50万人死亡。相比之下,C型流感病毒感染造成的临床症状较轻,而感染猪和牛的D型流感病毒与人类疾病无关^([1])。 | 王劭 | 2023 | 中国预防兽医学报2023，45，7： | 0 |
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