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1One-Pot Protolignin Extraction by Targeted Unlocking Lignin-Carbohydrate Esters via Nucleophilic Addition-Elimination Strategy显示文摘Protolignin extraction can facilitate structure elucidation and valorization of lignin in biorefinery,but is rather challenging due to the complex chemical bonds present.Here,we developed the in situ generated NH3-reline(IGNR)system to realize one-pot protolignin extraction from lignocellulose.In the IGNR system,reline consisting of choline chloride and urea acted as both a solvent and a nucleophile generator,and the nucleophilic addition-elimination mechanism was verified by model compound studies.The in situ generated NH3 could precisely cleave the lignin-carbohydrate esters in lignocellulose with a near-quantitative retention of carbohydrates.The extracted IGNR-Protolignin exhibited native lignin substructure with high molecular weight and highβ-O-4′content(41.5 per 100 aromatic units).In addition,the up-scaled kilogram reaction demonstrated the feasibility of the IGNR system for potential industrial application in a green and sustainable pathway.This work represents a breakthrough toward protolignin extraction in practice with the future goal of achieving total biorefinery.Yuhan Lou Xinyue Sun Yanyan Yu Suqing Zeng Yilin Li Yongzhuang Liu Haipeng Yu 2023Research2023,,4:0
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