|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Retinoic acid inducible gene-I,more than a virus sensor显示文摘Retinoic acid inducible gene-I(RIG-I)is a caspase recruitment domain(CARD)containing protein that acts as an intracellular RNA receptor and senses virus infection.After binding to double stranded RNA(dsRNA)or 5′-triphosphate single stranded RNA(ssRNA),RIG-I transforms into an open conformation,translocates onto mitochondria,and interacts with the downstream adaptor mitochondrial antiviral signaling(MAVS)to induce the production of type Ⅰ interferon and inflammatory factors via IRF3/7 and NF-κB pathways,respectively.Recently,accumulating evidence suggests that RIG-I could function in non-viral systems and participate in a series of biological events,such as inflammation and inflammation related diseases,cell proliferation,apoptosis and even senescence.Here we review recent advances in antiviral study of RIG-I as well as the functions of RIG-I in other fields. | Feng Liu Jun Gu | 2011 | Protein & Cell2011，2，5： | 5 |
| 2 | 视黄酸诱导基因1样受体(RLR)识别和调控的研究进展显示文摘天然免疫系统通过模式识别受体(PRR)识别病毒、细菌等病原体的病原体相关分子模式(PAMP),进而启动天然免疫反应、帮助机体清除入侵病原体。视黄酸诱导基因1(RIG-1)样受体(RLR)是PRR中具有DEx D/H-box RNA解螺旋酶结构域的一类受体,目前发现的RLR包括视黄酸诱导基因1(RIG-1/DDX58)、黑素瘤分化相关分子5(MDA5/IFIH1)和遗传学和生理学实验室蛋白2(LGP2/DHX58)。它们参与多种机体生理和病理过程,如抗病毒反应、自身免疫性疾病、肿瘤,其主要功能是识别病毒的寡聚核糖核苷酸,激活线粒体抗病毒信号蛋白[MAVS(IPS-1/VISA/cardif)]等关键接头分子,最终导致转录因子干扰素诱导因子3(IRF3)和核因子κB(NF-κB)活化,诱导1型干扰素和炎性细胞因子,从而介导宿主抗病毒免疫。本文重点阐述RLR在抗病毒免疫反应中识别RNA机制的研究进展。 | 李天亮 韩超峰 曹雪涛 | 2016 | 细胞与分子免疫学杂志2016，32，4： | 5 |
| 3 | 天然免疫受体RIG-Ⅰ的翻译后修饰及其功能调控显示文摘RIG-Ⅰ样受体(RIG-Ⅰ-like receptors,RLRs)属于DEx D/H box RNA解旋酶家族,在胞浆中感知RNA病毒相关分子模式(Pathogen-associated molecular patterns,PAMPs),介导下游信号转导和转录因子的活化,启动机体抗病毒天然免疫应答。 | 张华 韩超峰 曹雪涛 | 2015 | 中国免疫学杂志2015，31，7： | 2 |
| 4 | Cytosolic DNA sensing by cGAS:regulation,function,and human diseases显示文摘Sensing invasive cytosolic DNA is an integral component of innate immunity.cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special asymmetric cyclic-dinucleotide,2/3/-cGAMP,as the secondary messenger to bind and activate STING for subsequent production of type I interferons and other immune-modulatory genes.Hyperactivation of cGAS signaling contributes to autoimmune diseases but serves as an adjuvant for anticancer immune therapy.On the other hand,inactivation of cGAS signaling causes deficiency to sense and clear the viral and bacterial infection and creates a tumor-prone immune microenvironment to facilitate tumor evasion of immune surveillance.Thus,cGAS activation is tightly controlled.In this review,we summarize up-to-date multilayers of regulatory mechanisms governing cGAS activation,including cGAS pre-and post-translational regulations,cGAS-binding proteins,and additional cGAS regulators such as ions and small molecules.We will also reveal the pathophysiological function of cGAS and its product cGAMP in human diseases.We hope to provide an up-to-date review for recent research advances of cGAS biology and cGAS-targeted therapies for human diseases. | Le Yu Pengda Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 5 | Linking innate and adaptive immunity显示文摘The evolution of mechanisms to fight pathogens in plants and animals is reflected in the complexity of the components of their so-called immune systems. Higher vertebrates have | SHI Yi GAO George Fu | 2012 | Chinese Science Bulletin2012，57，31： | 0 |
| 6 | Regulation of cellular innate antiviral signaling by ubiquitin modification显示文摘主人模式识别受体(PRR ) 认出入侵病毒产生的联系病原体的分子的模式并且开始导致干扰素规章的因素的激活的一系列发信号的串联 3 (IRF3 ) 并且原子 factor-B (NF-B ) 和类型的随后的正式就职我干扰素(IFN ) 。由 ubiquitin 的蛋白质的 Posttranslational 修正在调停或调整起一个必要作用被触发病毒的调停 PRRs 的发信号。Deubiquitination 是 ubiquitination 的可逆过程,它在调整调停 PRRs 的发信号的角色最近被探索了。在这评论,我们首先在调停 PRRs 的发信号总结 ubiquitination 事件那被主人和病毒的 deubiquitinating 上的病毒的 nucleic 酸然后焦点触发被触发病毒的发信号的调停酶的规定调制 IRF3 和 NF-B 和类型的随后的正式就职的激活我 IFN。 | Dandan Lin Bo Zhong | 2015 | Acta Biochimica et Biophysica Sinica2015，47，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员