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| 1 | Electroacupuncture at Tianshu(ST25) and Zusanli(ST36) alleviates stress-induced irritable bowel syndrome in mice by modulating gut microbiota and corticotropin-releasing factor显示文摘OBJECTIVE: To investigate whether electroacupuncture(EA) at bilateral Tianshu(ST25) and Zusanli(ST36) acupoints could alleviate stress-induced irritable bowel syndrome(IBS) and evaluate its effect on gut microbiota and corticotropin-releasing factor(CRF). METHODS: Thirty C57BL/6 mice were randomly divided into the normal, water avoidance stress(WAS), and WAS+EA groups(10 mice per group). An experimental model of IBS was established by exposing the animals to WAS. The mice were treated with EA at the bilateral Tianshu(ST25) and Zusanli(ST36) acupoints. The abdominal withdrawal reflex test was conducted to evaluate visceral sensitivity in IBS. Gut microbiota was analyzed using 16S r RNA sequencing and analysis. The expression of CRF was determined using immuneofluorescence and quantitative real-time polymerase chain reaction. RESULTS: EA alleviated visceral hypersensitivity in a mouse model of WAS-induced IBS. It modulated the dysbiosis of gut microbiota induced by WAS. Moreover, it suppressed the WAS-induced overexpression of CRF in colon tissues. CONCLUSION: The findings of this study suggest that EA alleviated WAS-induced IBS via mechanisms possibly involving the modulation of the dysbiosis of gut microbiota and suppression of CRF expression. | SUN Mengzhu ZHANG Yujie SONG Yafang GUO Jing ZHAO Tingting WANG Yuhang PEI Lixia SUN Jianhua | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 1 |
| 2 | 肠易激综合征发病机制常见模型相关性分析显示文摘动物模型是肠易激综合征(irritable bowel syndrome, IBS)基础研究的基石,当前以发病机制为依托制备的动物模型应用较为广泛,但是常见大小鼠的模型制备方法各不相同,模型复杂多样,存在诸多问题,缺乏对发病机制和模型制备之间相关性的深入探讨。本研究对发病机制和应用较多的动物模型匹配程度进行对比分析,阐明其优缺点以及应用前景,可为IBS的基础研究提供模型制备依据。构建准确、高效、稳定的动物模型,才能够更好地验证研究中聚焦的发病机制。 | 李月婕 林璐璐 齐翎羽 杨娜娜 黄金 杨静雯 刘存志 | 2023 | 中国中医基础医学杂志2023，29，5： | 1 |
| 3 | 基于“神经-内分泌-免疫”网络探讨针刺治疗功能性胃肠病机制显示文摘功能性胃肠病(functional gastrointestinal disorders,FGIDs)是临床常见的消化系统疾病,主要表现为餐后饱胀不适、嗳气、腹痛、腹泻、腹胀等胃肠道症状,无明显器质性改变,包括功能性消化不良(functional dyspepsia,FD)、肠易激综合征(irritable bowel syndrome,IBS)、功能性腹胀、功能性便秘等。全球发病率约为40%^([1])。 | 韩名媛 梁吉 孙忠人 吕晓琳 朱嘉民 王羽心 杨成妍 高睿泽 尹洪娜 | 2023 | 中国中西医结合杂志2023，43，7： | 0 |
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