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| 1 | Cancer nanotechnology: Enhancing tumor cell response to chemotherapy for hepatocellular carcinoma therapy显示文摘Hepatocellular carcinoma(HCC)is one of the deadliest cancers due to its complexities,reoccurrence after surgical resection,metastasis and heterogeneity.In addition to sorafenib and lenvatinib for the treatment of HCC approved by FDA,various strategies including transarterial chemoembolization,radiotherapy,locoregional therapy and chemotherapy have been investigated in clinics.Recently,cancer nanotechnology has got great attention for the treatment of various cancers including HCC.Both passive and active targetings are progressing at a steady rate.Herein,we describe the lessons learned from pathogenesis of HCC and the understanding of targeted and non-targeted nanoparticles used for the delivery of small molecules,monoclonal antibodies,miRNAs and peptides.Exploring current efficacy is to enhance tumor cell response of chemotherapy.It highlights the opportunities and challenges faced by nanotechnologies in contemporary hepatocellular carcinoma therapy,where personalized medicine is increasingly becoming the mainstay.Overall objective of this review is to enhance our understanding in the design and development of nanotechnology for treatment of HCC. | Yongbing Sun Wen Ma Yuanyuan Yang Mengxue He Aimin Li Lei Bai Bin Yu Zhiqiang Yu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 8 |
| 2 | 磁性药物载体在抗肿瘤方面的研究进展显示文摘通过外加磁场的引导作用,使负载抗癌药物的磁性载体靶向定位于靶区,提高靶组织的药物浓度,有效降低药物对正常组织或细胞的毒副作用及其他不良反应。磁性药物载体还具有靶向性、缓释、控释等优点,已成了肿瘤靶向治疗常用的新型载体系统。本文综述了磁性药物载体磁性纳米颗粒、磁性脂质体、磁性微球在肿瘤治疗与诊断中的应用进展。 | 马丽霞 余兰 | 2019 | 药学研究2019，38，4： | 7 |
| 3 | Magnetic resonance imaging-guided and targeted theranostics of colorectal cancer显示文摘Colorectal cancer(CRC)is the most common gastrointestinal tract cancer worldwide and is associated with high morbidity and mortality.The development of nanosized drug delivery systems has provided a new direction in CRC treatment.Among these systems,magnetic nanoparticle(MNP)-based multifunctional platforms provide a novel strategy for magnetic resonance imaging(MRI)-related cancer theranostics.At the beginning o f this original review,the carcinogenesis and treatment status o f CRC are summarized.Then,diversified preparation and functionalization methods of MNPs are systematically analyzed,followed by MRIinvolved theranostic strategies.The latest progress in MRI-mediated multimode diagnosis and image-guided targeted therapy in CRC management is the main focus.Finally,the major challenges in promoting MRI-induced precise theranostics of CRC in clinical practice are discussed. | Yanan Li Jingqi Xin Yongbing Sun Tao Han Hui Zhang Feifei An | 2020 | Cancer Biology & Medicine2020，17，2： | 2 |
| 4 | One-dimensional nanochains consisting of magnetic core and mesoporous aluminosilicate for use as efficient nanocatalysts显示文摘Magnetic assembly at the nanoscale level brings potential possibilities in obtaining novel delicate nanostructures with unique physical, photonic or electronic properties. Interface surfactant micelle-directed assembly strategy holds great promising in fabricating ordered mesoporous materials with multifunctionality and pore parameter tunability. Combing these, herein, one-dimensional (1D) nanochains with well-aligned silica-coated magnetic particles as core and mesoporous aluminosilicate as shell are rational fabricated for the first time through magnetic field induced interface coassembly in biliquid system followed by the incorporation of Al species via in-situ chemical modification and transformation strategy. The obtained magnetic mesoporous aluminosilicate nanochains (MMAS-NCs) possess well-defined core-shell-shell sandwich nanostructure, tunable perpendicular mesopore channels in the shell (2.7–7.6 nm), high surface area (359 m^(2)·g^(-1)), abundant acidic sites, and superparamagnetism with a magnetization saturation of 13.8 emu·g^(-1). Thanks to the unique properties, the MMAS-NCs exhibit excellent performance in acting as magnetically recyclable superior solid acid catalysts and nanostirrers with high conversion of over 96.8%, selectivity of 95.0% in the deprotection reaction of benzaldehyde dimethylacetal to benzaldehyde. Moreover, MMAS-NCs exhibit an interesting pore size effect on the catalytic activity, namely, in the pore size range of 2–8 nm, the catalysts with larger pores show significantly enhanced catalytic activity due to the balanced mass transport and density of surface active sites. | Tong Zhang Qin Yue Panpan Pan Yuan Ren Xuanyu Yang Xiaowei Cheng Fahad A.Alharthi Abdulaziz A.Alghamdi Yonghui Deng | 2021 | Nano Research2021，14，11： | 0 |
| 5 | 保护气氛和样品状态对水热法制备Nd_(2)Fe_(14)B磁粉的影响显示文摘利用水热法,采用Nd(NO_(3))_(3)·6H_(2)O、Fe(NO_(3))_(3)·9H_(2)O和H_(3)BO_(3)为原料制备了Nd-Fe-B前驱体,再依次通过高温氧化退火,还原-扩散退火成功制备了主相为Nd_(2)Fe_(14)B的磁性粉体。利用X射线衍射(XRD)、振动样品磁强计(VSM)、扫描电子显微镜和透射电子显微镜(TEM)等表征手段,对产物的物相组成、磁性能及微观组织结构进行了分析,研究了还原-扩散退火过程中N_(2)、Ar和5%H_(2)/Ar混合气3种不同保护气氛以及片状和粉状两种不同样品状态对产物组成和性能的影响。结果表明,在N2中反应无法合成Nd_(2)Fe_(14)B相,在Ar中虽能成功合成Nd_(2)Fe_(14)B相,但因软磁相和非磁相杂质的存在,磁性能较差。粉状样品也无法在还原-退火过程中合成Nd_(2)Fe_(14)B相。只有片状样品在5%H2/Ar混合气的保护下进行还原-扩散退火,才可以成功合成杂质相少,磁性能高,颗粒尺寸为0.6~2μm,以Nd_(2)Fe_(14)B相为主相的磁粉。 | 王玲 张敏刚 朱峰帅 胡季帆 | 2021 | 功能材料2021，52，7： | 0 |
| 6 | 磁性纳米颗粒在环境中类固醇激素检测的应用与研究进展显示文摘类固醇激素(steroid hormones,SHs)作为动植物激素及合成代谢类激素,被广泛应用于农业、畜牧业及药业生产。为控制其在生产及环境中的用量和保障生物体的生命健康安全,准确测量食品中的类固醇激素成为一项重要任务。作为新兴的样品前处理方法,磁性固相萃取技术(magnetic-solid phase extraction,MSPE)被越来越多地应用于类固醇激素的检测中,该技术可极大缩短样品基质的分离时长,同时具有良好的吸附效率。主要综述近年来类固醇激素的主要检测技术,利用不同类型磁性纳米材料制备的新型磁性吸附剂及这些磁性纳米材料在SHs检测中的应用,总结不同基质、不同类型的磁性材料。同时,讨论研究磁性固相萃取在类固醇激素检测分析中的最新应用,为其在食品安全分析中的应用提供充分的理论依据。 | 刘宇尘 周剑 王敏 | 2022 | 食品工业2022，43，5： | 0 |
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