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| 1 | The key target of neuroprotection after the onset of ischemic stroke: secretory pathway Ca^(2+)-ATPase 1显示文摘The regulatory mechanisms of cytoplasmic Ca2+ after myocardial infarction-induced Ca2+ overload involve secretory pathway Ca2+-ATPase 1 and the Golgi apparatus and are well understood. However, the effect of Golgi apparatus on Ca2+ overload after cerebral ischemia and reperfusion remains unclear. Four-vessel occlusion rats were used as animal models of cerebral ischemia. The expression of secretory pathway Ca2+-ATPase 1 in the cortex and hippocampus was detected by immunoblotting, and Ca2+ concentrations in the cytoplasm and Golgi vesicles were determined. Results showed an overload of cytoplasmic Ca2+ during ischemia and reperfusion that reached a peak after reperfusion. Levels of Golgi Ca2+ showed an opposite effect. The expression of Golgi-specific secretory pathway Ca2+-ATPase 1 in the cortex and hippocampus decreased before ischemia and reperfusion, and increased after reperfusion for 6 hours. This variation was similar to the alteration of calcium in separated Golgi vesicles. These results indicate that the Golgi apparatus participates in the formation and alleviation of calcium overload, and that secretory pathway Ca2+-ATPase 1 tightly responds to ischemia and reperfusion in nerve cells. Thus, we concluded that secretory pathway Ca2+-ATPase 1 plays an essential role in cytosolic calcium regulation and its expression can be used as a marker of Golgi stress, responding to cerebral ischemia and reperfusion. The secretory pathway Ca2+-ATPase 1 can be an important neuroprotective target of ischemic stroke. | Li-hua Li Xiang-rong Tian Zhi-ping Hu | 2015 | Neural Regeneration Research2015，10，8： | 13 |
| 2 | 分析细胞学家薛绍白研究员显示文摘中医世家分析细胞学家薛绍白研究员于1934年8月23日出生于天津。薛先生在家中排行老大,下有一个弟弟和三个妹妹。薛先生出生于中医世家,祖父及父亲润珊公均在天津市行医,造福于一方百姓。润珊公为我国近代著名中医学和中医教育家施今墨先生的嫡传弟子。润珊公学徒期间就在施家住宿,伙食上与施家长子待遇相同。出师后润珊公在天津市行医,尤其擅长妇科、消化科和儿科。薛先生少小时家道尚属殷实,故而自幼便受到了非常良好的教育。薛先生从天津培才小学毕业后,初中阶段升入天津市南开中学,高中升入天津市第三中学(时校址天津城西北角铃铛阁大街),中、小学母校皆为历史名校。薛先生1952年中学毕业之后,考入北京师范大学生物系,1956年本科毕业后保送进入动物生理研究班,并于1958年研究班毕业后留校任教。薛先生的教学和科研事业始于北京师范大学,一生工作时间之中除了两次都不到一年的国际访问,他将其宝贵年华和精力都贡献给了北京师范大学。 | 崔宗杰 | 2019 | 中国细胞生物学学报2019，41，10： | 0 |
| 3 | 高尔基器钙库显示文摘回顾学科在高尔基器钙库钙研究方面所作出的贡献,以及该领域的近期概况.重点阐述高尔基器钙库概念的提出,以及目前已知的高尔基器钙库相关功能蛋白如SPCA1/2、GAAP的结构与功能. | 崔宗杰 | 2023 | 北京师范大学学报(自然科学版)2023，59，4： | 0 |
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