| 1 | 彩色多普勒血流显像探查老年性白内障患者黄斑区病变的应用价值显示文摘目的观察彩色多普勒血流显像(CDFI)探查老年性白内障患者黄斑区病变的应用价值。方法横断面描述性研究。2017年12月1~30日就诊于北京同仁医院眼科中心的老年性白内障患者720例1380只眼纳入研究。其中,男性330例629只眼,女性390例751只眼;平均年龄(70.35±19.05)岁;右眼716只眼。视力0.05~0.8。眼底均可观察。所有患眼均行频域OCT、CDFI检查。采用德国Carl Zeiss Meditec公司Cirrus HD-Model 5000 OCT仪对患眼黄斑区进行扫描,测量黄斑中心凹厚度(CFT)和平均厚度(AT)。采用意大利百胜医疗集团MyLab 90彩色多普勒超声诊断仪行CDFI检查。两种方法对黄斑区病变的检出率比较行χ^2检验;采用评价诊断试验的统计方法,制作交叉表比较频域OCT与CDFI对黄斑区病变诊断的一致性。CFT、AT以及黄斑区有无前膜、视网膜皱褶、视网膜囊样水肿、硬性渗出、黄斑裂孔或板层黄斑裂孔、神经上皮层浅脱离、RPE脱离、玻璃体黄斑牵拉与CDFI黄斑区病变检出相关性行logistic回归分析。结果1380只眼中,频域OCT检查发现黄斑区病变239只眼(17.3%);CDFI探查发现黄斑区异常回声161只眼(11.7%)。频域OCT、CDFI对黄斑区病变的检出率比较,差异有统计学意义(χ^2=851.661,P<0.001),但检出结果一致性较好(κ=0.766,P=0.000)。Logistic回归分析结果显示,CDFI黄斑区病变检出与视网膜皱褶、视网膜层间囊肿及CFT相关(r=1.396、1.041、0.120,P<0.01)。结论CDFI可以有效发现影响老年性白内障患者视力预后的黄斑区病变。 | 沈琳 杨文利 李栋军 王子杨 陈伟 赵琦 李逸丰 崔蕊 鲜军舫 | 2020 | 中华眼底病杂志2020，36，1： | 4 |
| 2 | Infl iximab relieves blood retinal barrier breakdown through the p38 MAPK pathway in a diabetic rat model显示文摘AIM:To clarify the mechanism of infliximab treatment in diabetic macular edema(DME) and to provide a new alternative therapy for DME.METHODS:Rats were randomly divided into the control group,the model group and the infliximab treatment group.A diabetic rat model was created.The concentration of TNF-α in the vitreous body was detected by ELISA.The expressions of B-Raf,p38,claudin-1 and occludin in the retina were detected by Western blot.The integrity of the blood retinal barrier(BRB) was measured using Evan's blue as a tracer.RESULTS:After three months and six months of the diabetes model,the vitreous TNF-α level in the model group was higher than that of the control group.It was also higher in treated group than that of the control group but was lower than that of the model group.The differences among the three groups were statistically significant(at 3 mo,F=857.098,P<0.001;6 mo,F=1261.897,P<0.001).The retina B-Raf and p38 levels in the model group were higher than that of the control group.They were also higher in treated group than that of the control group but were lower than that of the model group.The differences among the three groups were statistically significant(B-Raf at 3 mo,F=106.596,P<0.001 and at 6 mo,F=200.681,P<0.001;p38 at 3 mo,F=41.662,P<0.001 and at 6 mo,F=67.979,P<0.001).The retina claudin-1 and occludin levels in the model group were lower than that of the control group.They were also lower in treated group than that of the control group but were higher than that of the model group.The differences among three groups were statistically significant(claudin-1 at3 mo,F=139.088,P<0.001 and at 6 mo,F=128.415,P<0.001;occludin at 3 mo,F=92.733,P<0.001 and at 6 mo,F=104.478,P<0.001).The retinal Evans blue leakage in the model group was higher than that of the control group.It was also higher in treated group than that of the control group but was lower than that of the model group.The differences among the three groups were statistically significant(at 3 mo,F=447.946,P<0.001;at 6 mo,F=1610.732,P<0.001).CONCLUSION:In a diabetic rat model,infliximab may relieve TNF-α induced BRB breakdown via the B-Raf and p38 signaling pathway. | Mao-Song Xie Yong-Zheng Zheng Li-Bin Huang Guo-Xing Xu | 2017 | International Journal of Ophthalmology(English edition)2017，10，12： | 2 |
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