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| 1 | Conversion of mouse fibroblasts into oligodendrocyte progenitor-like cells through a chemical approach显示文摘Transplantation of oligodendrocyte progenitor cells (OPCs) is a promising way for treating demyelinating diseases. However, generation of scalable and autologous sources of OPCs has proven difficult. We previously established a chemical condition M9 that could specifically initiate neural program in mouse embryonic fibroblasts. Here we found that M9 could induce the formation of colonies that undergo mesenchymal-to-epithelial transition at the early stage of reprogramming. These colonies may represent unstable and neural lineage-restricted intermediates that have not established a neural stem cell identity. By modulating the culture signaling recapitulating the principle of OPC development, these intermediate cells could be reprogrammed towards OPC fate. The chemical-induced OPC-like cells (ciOPLCs) resemble primary neural stem cell-derived OPCs in terms of their morphology, gene expression, and the ability of self-renewal. Upon differentiation, ciOPLCs could produce functional oligodendrocytes and myelinate the neuron axons in vitro, validating their OPC identity molecularly and functionally. Therefore, our study provides a non-integrating approach to OPC reprogramming that may ultimately provide an avenue to patient-specific cell-based or in situ regenerative therapy. | Chang Liu Xu Hu Yawen Li Wenjie Lu Wenlin Li Nan Cao Saiyong Zhu Jinke Cheng Sheng Ding Mingliang Zhang | 2019 | Journal of Molecular Cell Biology2019，11，6： | 1 |
| 2 | 单细胞组学数据库的研究进展显示文摘随着测序技术的发展,目前单细胞测序已经成为生命科学各研究方向的前沿技术.单细胞测序技术是指在单个细胞的水平上对其携带的遗传信息进行高通量测序分析的技术.在2011年和2013年,单细胞测序技术分别被《Nature Methods》和《Science》列为年度最值得期待和关注的技术之一.随后单细胞测序数据呈现指数级增长,使得在海量的数据中寻找有用信息成为一个难题,整合单细胞测序数据的数据库有效地解决了该问题.概述了近年来有关单细胞数据库的研究进展,结合单细胞测序技术的重要性探讨单细胞数据库的功能特点及适用范围,并提出未来单细胞数据库发展的趋势. | 蔡浩洋 | 2022 | 四川师范大学学报(自然科学版)2022，45，4： | 0 |
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