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| 1 | Role of microbiota on lung homeostasis and diseases显示文摘The lungs, as a place of gas exchange, are continuously exposed to environmental stimuli, such as allergens, microbes, and pollutants. The development of the culture-independent technique for microbiological analysis, such as 16 S rRNA sequencing,has uncovered that the lungs are not sterile and, in fact, colonized by diverse communities of microbiota. The function of intestinal microbiota in modulating mucosal homeostasis and defense has been widely studied; however, the potential function of lung microbiota in regulating immunity and homeostasis has just begun. Increasing evidence indicates the relevance of microbiota to lung homeostasis and disease. In this review, we describe the distribution and composition of microbiota in the respiratory system and discuss the potential function of lung microbiota in both health and acute/chronic lung disease. In addition, we also discuss the recent understanding of the gut-lung axis, because several studies have revealed that the immunological interaction among the gut, the lung, and the microbiota was involved in this issue. | Jian Wang Fengqi Li Zhigang Tian | 2017 | Science China(Life Sciences)2017，60，12： | 18 |
| 2 | Gut-liver axis:gut microbiota in shaping hepatic innate immunity显示文摘Gut microbiota play an essential role in shaping immune cell responses. The liver was continuously exposed to metabolic products of intestinal commensal bacterial through portal vein and alteration of gut commensal bateria was always associated with increased risk of liver inflammation and autoimmune disease. Considered as a unique immunological organ, the liver is enriched with a large number of innate immune cells. Herein, we summarize the available literature of gut microbiota in shaping the response of hepatic innate immune cells including NKT cells, NK cells, γδ T cells and Kupffer cells during health and disease. Such knowledge might help to develop novel and innovative strategies for the prevention and therapy of innate immune cell-related liver disease. | xunyao wu zhigang tian | 2017 | Science China(Life Sciences)2017，60，11： | 13 |
| 3 | Macleaya cordata extract alleviated oxidative stress and altered innate immune response in mice challenged with enterotoxigenic Escherichia coli显示文摘This study examines the effects of dietary Macleaya cordata extract(MCE) on bacterial burden and resistance to enterotoxigenic Escherichia coli(ETEC) in ICR mice. ICR mice were randomly distributed into one of the following groups:(i) basal diet;(ii)basal diet with 200 mg kg–1 MCE;(iii) basal diet challenged with ETEC;and(iv) basal diet with 200 mg kg–1 MCE and challenged with ETEC. Following a 7-day period of pre-treatment, CTRL-ETEC and MCE-ETEC mice were subjected to oral infection using 5×108 E. coli SEC 470. The results showed dietary 200 mg kg–1 MCE markedly reduced intestinal ETEC burden(P<0.05) and the disease-associated mortality was significantly alleviated in the MCE treated group(P<0.05). In addition,dietary MCE markedly alleviated ETEC-induced oxidative stress, evidenced by the lowered methane dicarboxylic aldehyde(MDA) abundance and enhanced activities of catalase and glutathione peroxidase(P<0.05). Furthermore, MCE mice exhibited higher immune activity, which might have further mediated ETEC infection. These results indicate MCE plays a preventative role with respect to ETEC infection. Future research should aim to develop MCE as a therapeutic approach to the promotion of intestinal health and a safeguard against ETEC infection. | Guiping Guan Sujuan Ding Yulong Yin Veeramuthu Duraipandiyan Naif Abdullah Al-Dhabi Gang Liu | 2019 | Science China(Life Sciences)2019，62，8： | 12 |
| 4 | 痤疮发病机制的免疫学研究进展显示文摘痤疮是一种常见的炎症性皮肤病,炎症反应贯穿了疾病的整个过程。研究表明,固有免疫和适应性免疫的多个环节均参与了痤疮的炎症反应,其中皮肤屏障功能的改变,Toll样受体、NOD样受体、炎症小体的活化,固有免疫分子的调节及相关细胞因子的产生均可直接或间接地参与痤疮的炎症反应。此外,体内T、B淋巴细胞受到刺激后,自身活化、增殖和分化产生一系列生物学效应也可诱导免疫应答,引起痤疮的炎症反应。深入了解痤疮的免疫反应机制的研究进展,有助于进一步开展相关研究和开发潜在的治疗靶点,为痤疮的治疗提供更好的手段。 | 邵蕾 梁景耀 陈丽洁 刘玉梅 王建琴 | 2017 | 国际皮肤性病学杂志2017，43，6： | 10 |
| 5 | STING信号通路及其功能显示文摘固有免疫反应是宿主抵御外来病原微生物的第一道防线。宿主可以通过模式识别受体识别病原体相关的分子模式,进而起始抗病毒免疫反应。干扰素激活蛋白(STING)是固有免疫反应中一个重要分子,其在防御病毒及胞内细菌感染、介导Ⅰ型干扰素产生过程中发挥重要功能。STING既可以直接识别环二核苷酸,也可以作为接头蛋白促进下游信号通路的转导;STING作为信号转导级联反应中的重要组成部分,既可以在病原体(病毒、细菌、寄生虫等)感染时发挥免疫防御作用,也可以在肿瘤发生时发挥抗肿瘤免疫反应。当STING信号通路过度激活时,也可能引起一系列的自身免疫性疾病。 | 陈巍 柯志意 黄卫人 | 2017 | 医学综述2017，23，14： | 6 |
| 6 | Genome re-sequencing analysis uncovers pathogenecity-related genes undergoing positive selection in Magnaporthe oryzae显示文摘Rice blast caused by Magnaporthe oryzae(M.oryzae) is one of the most destructive diseases,which causes significant rice yield losses and affects global food security.To better understand genetic variations among different isolates of M.oryzae in nature,we re-sequenced the genomes of two field isolates,CH43 and Zhong-10-8-14,which showed distinct pathogenecity on most of the rice cultivars.Genome-wide genetic variation analysis reveals that ZHONG-10-8-14 exhibits higher sequence variations than CH43.Structural variations(SVs) detection shows that the sequence variations primarily occur in exons and intergenic regions.Bioinformatics analysis for gene variations reveals that many pathogenecity-related pathways are enriched.In addition,193 candidate effectors with various DNA polymorphisms were identified,including two known effectors AVR-Pik and AVR-Pital.Comparative polymorphism analysis of thirteen randomly selected effectors suggests that the genetic variations of effectors are under positive selection.The expression pattern analysis of several pathogenecity-related variant genes indicates that these genes are differentially regulated in two isolates,with much higher expression levels in Zhong-10-8-14 than CH43.Our data demonstrate that the genetic variations of effectors and pathogenecity-related genes are under positive selection,resulting in the distinct pathogenicities of CH43 and Zhong-10-8-14 on rice. | Jidong Cao Yongqi Yu Junkai Huang Rui Liu Yan Chen Suiyan Li Jun Liu | 2017 | Science China(Life Sciences)2017，60，8： | 6 |
| 7 | cGAS-STING信号通路和自身免疫性疾病显示文摘cGAS-STING信号通路是天然免疫系统中重要的模式识别及效应通路之一,主要负责识别存在于细胞浆的DNA分子,并激活下游信号通路产生Ⅰ型干扰素(IFN-Ⅰ)和其他炎症因子。cGAS-STING通路的适当激活有助于机体实现自我保护,而过度激活则可导致自身反应性炎症疾病和自身免疫性疾病(AID)的发生。如今,越来越多的研究证实,cGAS-STING信号通路的异常与AID的发生发展密切相关。因此,了解cGAS-STING通路的发生机制有助于提高人们对AID的认识,从而更好地实现对AID的诊治。本文就近年来cGAS-STING信号通路与AID的相关性研究进展进行综述。 | 俞宛君 夏圣 | 2021 | 中国免疫学杂志2021，37，14： | 5 |
| 8 | Regional immunity in tissue homeostasis and diseases显示文摘The immune system functions in the organ/tissue of the body.The immune cell differentiation and function are influenced by the organ/tissue microenvironments in which they reside,and the interaction of immune cells with the organ/tissue microenvironments may affect and even determine the outcome of the immune responses(Hu and Pasare,2013;Zajac and Harrington,2014).It has been | Zhigang Tian Xuetao Cao Yongyan Chen Qunyan Lyu | 2016 | Science China(Life Sciences)2016，59，12： | 4 |
| 9 | Toll样受体相关疾病研究进展显示文摘Toll样受体(Toll-like receptors, TLRs)家族存在于所有活的多细胞生物中。研究表明,TLRs在对机体天然免疫、识别病原体方面包括感染性、自身免疫性、过敏性、炎症和癌症在内的多种疾病的发病机制中发挥了非常重要的作用。简要介绍了TLRs家族受体相关的常见疾病,结合已有的成果对相关疾病相关受体的研究方法及应用现状进行阐述。最后,对Toll样受体为人类克服相关疾病的未来发展方向进行展望。 | 杨宏鹏 张首国 曹莹 彭涛 温晓雪 王林 胡利明 | 2022 | 科学技术与工程2022，22，35： | 4 |
| 10 | 革兰氏阳性病原菌表面毒力因子及其宿主识别机制显示文摘革兰氏阳性病原菌拥有多种毒力因子,它们在病原菌生长及侵染宿主的各个时期发挥着重要作用.它们不仅参与病原菌的细胞分裂和增殖,同时还介导病原菌黏附和侵染宿主.基于本研究组近十年来对两种重要的人类病原微生物肺炎链球菌和金黄色葡萄球菌的研究,并整合国内外相关研究进展,简要综述了病原菌重要表面毒力因子的结构和功能,以及与宿主天然免疫模式识别受体相互作用的分子机制. | 江永亮 金腾川 陈宇星 周丛照 | 2017 | 中国科学:生命科学2017，47，1： | 3 |
| 11 | Rab20 is critical for bacterial lipoprotein tolerization-enhanced bactericidal activity in macrophages during bacterial infection显示文摘Bacterial cell wall component-induced tolerance represents an important protective mechanism during microbial infection.Tolerance induced by the TLR2 agonist bacterial lipoprotein(BLP)has been shown to attenuate the inflammatory response,and simultaneously to augment antimicrobial function,thereby conferring its protection against microbial sepsis.However,the underlying mechanism by which BLP tolerance augments bactericidal activity has not been fully elucidated.Here,we reported that the induction of BLP tolerance in murine macrophages upregulated the expression of Rab20,a membrane trafficking regulator,at both the mRNA and protein levels upon bacterial infection.The knockdown of Rab20 with Rab20 specific siRNA(siRab20)did not affect the phagocytosis of Escherichia coli(E.coli),but substantially impaired the intracellular killing of the ingested E.coli in BLP-tolerized macrophages.Furthermore,Rab20 was associated with GFP-E.coli containing phagosomes,and BLP tolerization resulted in the enhanced maturation of GFP-E.coli-containing phagosomes associated with Rab20 and strong lysosomal acidification.The knockdown of Rab20 substantially diminished lysosome acidification and disturbed the fusion of GFP-E.coli containing phagosomes with lysosomes in BLP-tolerized macrophages.These results demonstrate that Rab20 plays a critical role in BLP tolerization-induced augmentation of bactericidal activity via promoting phagosome maturation and the fusion of bacteria containing phagosomes with lysosomes. | Shuqi Zhao Dalin Xi Junwei Cai Wenting Chen Jing Xiang Na Peng Juan Wang Yong Jiang Zhuzhong Mei Jinghua Liu | 2020 | Science China(Life Sciences)2020，63，3： | 2 |
| 12 | cGAS-STING通路在肠道屏障中的作用研究进展显示文摘干扰素基因刺激因子(STING)是一种内质网内的衔接蛋白,可通过其上游的DNA感受器环鸟苷酸腺苷酸合成酶(cGAS)识别胞质中异常存在的双链DNA(dsDNA),诱导Ⅰ型干扰素(IFN-I)的产生,参与机体的天然免疫过程。肠道是一个高度复杂的微环境,与潜在的有害病原体不断相互作用,目前已有大量研究表明cGAS-STING通路可影响肠道屏障功能,但它在肠道稳态中的作用是相互矛盾的。为进一步深入探究cGAS-STING通路在肠道相关疾病中的作用,本文就cGAS-STING通路在调控肠道机械屏障、生物屏障、免疫屏障、化学屏障的正常生理功能中的具体机制进行综述,为针对cGAS-STING通路的胃肠道前瞻性治疗策略提供新思路。 | 吕梦婷 章越凡 | 2022 | 中南药学2022，20，11： | 1 |
| 13 | 酵母双杂交技术筛选与STING蛋白相互作用的蛋白显示文摘目的 应用酵母双杂交技术筛选出与干扰素刺激因子(stimulator of IFN genes,STING)相作用的分子,为深入研究STING蛋白的分子水平的功能奠定基础。方法 利用基因克隆的方法构建酵母双杂交质粒 pGBKT7-STING。应用酵母杂交技术从人胚肾cDNA 库中筛选出与STING蛋白相互作用的蛋白,并在酵母中从新验证其相互作用。结果 应用酵母双杂交系统筛选出与STING蛋白相作用的19个候选分子,成功构建 pGBKT7-STING 质粒,且可以在酵母中表达。结论 应用酵母双杂交技术可筛选出与STING蛋白相互作用蛋白。 | 刘晶莹 李胜龙 宋佳 富丹 | 2019 | 牡丹江医学院学报2019，40，3： | 0 |
| 14 | Advancement in regional immunity and its clinical implication显示文摘Organs in our body have formed their own unique immune surveillance system that is finely tuned by in situ milieu. Sequestrated tissue-resident immune cells differ from their counterparts in circulation and participate in tissue physiological activities and the maintenance of local homeostasis. Dysregulation of regional immunity leads to organ-specific inflammatory injuries. Here we review the recent developments in the field of tissue-resident immune cells and organ-specific regional immunity, and discuss their clinical implication. | chen zhou luxi sun lidan zhao xuan zhang | 2017 | Science China(Life Sciences)2017，60，11： | 0 |
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