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| 1 | Tripodalsporormielones A-C,unprecedented cage-like polyketides with complex polyvdent bridged and fused ring systems显示文摘A chemical investigation on Sporormiella sp.led to the isolation and structural elucidation of tripodalsporormielones Ae C(1-3),a new class of polyketide possessing unprecedented cage-like skeletons with polyvdent bridged and fused ring systems.These polyketides with cage-like skeletons were characterized as a high non-protonated carbon-containing system,which resulted in few HMBC correlations observed and made the accurate structures hard to be obtained by NMR.Especially,some signals of non-protonated sp;carbons are weak and even unobservable in compound 1.In order to establish the structure of 1,the calculated NMR with DP4 evaluation was applied to determine the structure from the plausible structure candidates obtained from the detailed NMR analysis.Based on NMR experiments and calculated NMR,the structures of isolated compounds were established and confirmed by X-ray technology.Through chiral isolation,the optically pure enantiomers of 1 and 3 were obtained,and their absolute configurations were determined based on ECD quantum chemical calculation.Based on the isolated compounds and our previous work,1-3 would be derived from 3-methylorcinaldehyde,and their plausible biosynthetic mechanism was proposed.Furthermore,1 exhibited obvious short-term memory improvement activity on an Alzheimer’s disease fly model. | Guodong Chen Bingxin Zhao Meijuan Huang Jia Tang Yanbing Li Liangdong Guo Rongrong He Dan Hu Xinsheng Yao Hao Gao | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 1 |
| 2 | 天然产物中炔基的生物合成机制研究及其应用显示文摘炔基是许多药物、活性天然产物以及功能材料等的重要官能团,因此,开发高效的炔类化合物合成策略具有重要意义。传统的合成策略包括通过化学反应直接制备,或以简单的炔类前体为底物,通过生物转化获得。随着合成生物学技术的飞速发展,从头生物合成有望成为炔类化合物合成的新策略。该策略绿色环保,易于操作,是对传统化学合成以及生物转化策略的有效补充。炔类化合物从头生物合成的关键是阐明天然产物中炔基的生物合成机制,获得炔基合成酶。本文重点总结了不同天然产物中炔基的生物合成研究进展,包括脂肪酸、聚酮、聚酮-非核糖体肽杂合体、氨基酸以及杂萜,并介绍了炔基合成酶在炔类化合物从头生物合成中的应用。尽管炔基的生物合成研究近年来取得了长足发展,但在炔基合成酶的种类挖掘及其底物特异性拓展方面还有待进一步加强,从而为炔类化合物的从头生物合成提供更多可供选择的酶工具。 | 吕建明 赵欢 胡丹 高昊 | 2021 | 合成生物学2021，2，5： | 1 |
| 3 | Thirteen new peptaibols with antimicrobial activities from Trichoderma sp.显示文摘From the fungus Trichoderma sp., we isolated seven novel 18-residue peptaibols, neoatroviridins E-K ( 1−7 ), and six new 14-residue peptaibols, harzianins NPDG J-O ( 8−13 ). Additionally, four previously characterized 18-residue peptaibols neoatroviridins A-D ( 14−17 ) were also identified. The structural configurations of the newly identified peptaibols ( 1−13 ) were determined by comprehensive nuclear magnetic resonance (NMR) and high-resolution electrospray ionization tandem mass spectrometry (HR-ESI-MS/MS) data. Their absolute configurations were further determined using Marfey’s method. Notably, compounds 12 and 13 represent the first 14-residue peptaibols containing an acidic amino acid residue. In antimicrobial assessments, all 18-residue peptaibols ( 1 − 7 , 14 − 17 ) exhibited moderate inhibitory activities against Staphylococcus aureus 209P, with minimum inhibitory concentration (MIC) values ranging from 8−32 μg·mL^(−1). Moreover, compound 9 exhibited moderate inhibitory effect on Candida albicans FIM709, with a MIC value of 16 μg·mL^(−1). | TANG Pan HUANG Dan ZHENG Kai-Xuan HU Dan DAI Ping LI Chuan-Hui QIN Sheng-Ying CHEN Guo-Dong YAO Xin-Sheng GAO Hao | 2023 | Chinese Journal of Natural Medicines2023，21，11： | 0 |
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