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| 1 | 海洋生物诞生过程、新资源发掘与高值利用显示文摘本文以46亿年来地球、海洋及生命的形成与演化为主线,简要回顾了生命体由简单到复杂、从低级向高级、从水生到陆生逐级演化的历史进程,以及重大环境变化事件对生物毁灭性灭绝、生物适应与多样性演化的影响,阐明海洋尤其热带海洋在生命诞生、孕育及庇护等过程中所发挥的不可替代作用。同时,分析了热带海洋生物资源多样性中心形成的重要自然环境因素及可能机制。并针对印太交汇区深海极端环境微生物生态系统、浅海典型的海草/藻床、珊瑚礁、生物多样性和热带渔业资源,论述了热带海洋生物多样性资源的保护、发掘与高值开发利用。 | 刘建国 刘洋 王海艳 庞通 肖永双 杨娜 | 2021 | 海洋与湖沼2021，52，2： | 4 |
| 2 | Adverse Effect of TiO2 Nanoparticles on Antioxidant System and Antitumor Activities of Macroalgae Gracilaria lemaneiformis显示文摘Recently,the widespread use of TiO2 nanoparticles(nano-TiO2)has attracted the global concern regarding their adverse effects to aquatic organisms.Nanoparticles may get to the aquatic environments and harm the growth of algae.This paper presents the studies of nano-TiO2 concentrations influence on the photosynthetic characteristics,antioxidant system and antitumor activity of marine macroalgae Gracilaria lemaneiformis after exposed to 0,5,10,20 or 40 mg L^-1 of nano-TiO2.Results showed that the photosynthetic pigment content of G.lemaneiformis obviously decreased and the antioxidant defense system was significantly disturbed after exposure to nano-TiO2.Compared with control,the maximum level of malondialdehyde showed 3.3-fold increase for 15 days exposure to nano-TiO2.The activity of superoxide dismutase and catalase enhanced obviously by 1.10-2.24-fold.The aqueous extract of G.lemaneiformis(AEGL)possesses anticancer activity against HepG2 liver cancer cells proliferation and the 48 h-cell inhibition exceeds 35%.But the toxicity of nano-TiO2 would inhibit the anticancer activity of AEGL.When G.lemaneiformis was exposed to nano-TiO2,the effect of the aqueous extract of G.lemaneiformis on the cell inhibition,reactive oxygen species production,apoptosis,cycle arrest of HepG2 cells significantly lessened,and which were linearly associated with nano-TiO2 exposure concentration.Those results further confirmed that nano-TiO2 can inhibit the anticancer activity of G.lemaneiformis.The results in this work imply that macroalgae can be an effective biomarker of nano-TiO2 contaminant,and can be useful indicator to evaluate ecological effects of increasing pollutants in marine ecosystem. | LIU Jie YIN Pinghe ZHAO Ling | 2019 | Journal of Ocean University of China2019，18，5： | 0 |
| 3 | 小檗碱对小鼠艾氏腹腔积液肿瘤细胞增殖的影响及其机制显示文摘目的探讨小檗碱对小鼠艾氏腹腔积液肿瘤细胞的影响,并阐述其作用机制。方法将50只小鼠随机分为空白对照组、环磷酰胺(CTX)组、小檗碱3组(不同剂量),每组各10只。每只鼠注入0.5 ml艾氏腹腔积液肿瘤细胞,CTX组予CTX 5 mg/kg,小檗碱组分别予小檗碱5、10、15 mg/kg腹腔注射。计算小鼠生存时间及生命延长率,并测定巨噬细胞吞噬功能、肿瘤坏死因子α(TNF-α)细胞杀伤率和自然杀伤(NK)细胞活性。结果存活时间空白对照组、CTX组、小檗碱不同剂量(5、10、15 mg/kg)组分别为(12.2±3.3)d、(17.8±4.6)d、(15.4±2.8)d、(17.5±3.0)d、(19.8±2.7)d,除空白对照组外,各组生命延长率分别为39.7%、29.2%、42.8%、59.7%。用药组与空白对照组比较差异均有统计学意义(P<0.05);CTX组与小檗碱组比较差异无统计学意义(P>0.05);小檗碱组随给药剂量增加存活时间有所延长,用药剂量与小鼠存活时间呈正相关,差异有统计学意义(P<0.05)。用药组巨噬细胞吞噬功能、TNF-α细胞杀伤率、NK细胞活性与空白对照组比较差异有统计学意义(P<0.05,P<0.01);CTX组与小檗碱组比较差异无统计学意义(P>0.05);小檗碱组间巨噬细胞吞噬功能比较差异无统计学意义(P>0.05)。TNF-α细胞杀伤率随小檗碱剂量增大呈增高趋势,小檗碱15 mg/kg组NK细胞的活性有所降低,但差异无统计学意义(P>0.05)。结论小檗碱对小鼠肿瘤具有一定的抑制和促溶作用,可明显延长小鼠存活时间。 | 李佳青 刘丽红 李文妍 王旭瑞 | 2012 | 临床误诊误治2012，25，12： | 0 |
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