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| 1 | Xueshuantong improves cerebral blood perfusion in elderly patients with lacunar infarction显示文摘A total of 64 patients with acute lacunar infarction were enrolled within 24 hours of onset. The patients received conventional therapy (antiplatelet drugs and hypolipidemic drugs) alone or conventional therapy plus 450 mg Xueshuantong once a day. The main ingredient of the Xueshuantong lyophilized powder used for injection was Panax notoginseng saponins. Assessments were made at admission and at discharge using the National Institutes of Health Stroke Scale, the Activity of Daily Living and the Mini-Mental State Examination. Additionally, the relative cerebral blood flow, relative cerebral blood volume and relative mean transit time in the region of interest were calculated within 24 hours after the onset of lacunar infarction, using dynamic susceptibility contrast magnetic resonance perfusion imaging technology. Patients underwent a follow-up MRI scan after 4 weeks of treatment. There was an improvement in the Activity of Daily Living scores and a greater reduction in the scores on the National Institutes of Health Stroke Scale in the treatment group than in the control group. However, the Mini-Mental State Examination scores showed no significant differences after 4 weeks of treatment. Compared with the control group, the relative cerebral blood flow at discharge had increased and showed a greater improvement in the treatment group. Furthermore, there was a reduction in the relative mean transit time at discharge and the value was lower in the treatment group than in the control group. The experimental findings indicate that Xueshuantong treatment improves neurological deficits in elderly patients with lacunar infarction, and the mechanism may be related to increased cerebral perfusion. | Qifeng Gui Yunmei Yang Shihong Ying Minming Zhang | 2013 | Neural Regeneration Research2013，8，9： | 27 |
| 2 | 老年糖尿病合并脑小血管病中医证型的临床研究显示文摘随着人口老龄化加速和脑血管疾病危险因素高发,老年糖尿病合并脑小血管病(cerebral small vessel diseases,CSVD)日益增多。脑小血管指大脑小的穿支动脉和小动脉(直径40~200μm)、毛细血管及小静脉,它们构成了脑组织血供的基本单位,对脑功能的维持起着重要作用。而糖尿病作为CSVD的一个重要危险因素,易破坏小血管,故糖尿病患者中CSVD发病率较高。因CSVD存在临床症状较轻、 | 陈玖 李友第 归崎峰 杨云梅 | 2015 | 中华危重症医学杂志(电子版)2015，8，4： | 5 |
| 3 | Communicating with the non-dominant hemisphere:Implications for neurological rehabilitation显示文摘Aphasic syndromes usually result from injuries to the dominant hemisphere of the brain. Despite the fact that localization of language functions shows little interindividual variability, several brain areas are simultaneously activated when language tasks are undertaken. Mechanisms of language recovery after brain injury to the dominant hemisphere seem to be relatively stereotyped, including activations of perilesional areas in the acute phase and of homologues of language areas in the non-dominant hemisphere in the subacute phase, later returning to dominant hemisphere activation in the chronic phase. Plasticity mechanisms reopen the critical period of language development, more specifically in what leads to disinhibition of the non-dominant hemisphere when brain lesions affect the dominant hemisphere. The non-dominant hemisphere plays an important role during recovery from aphasia, but currently available rehabilitation therapies have shown limited results for efficient language improvement. Large-scale randomized controlled trials that evaluate well-defined interventions in patients with aphasia are needed for stimulation of neuroplasticity mechanisms that enhance the role of the non-dominant hemisphere for language recovery. Ineffective treatment approaches should be replaced by more promising ones and the latter should be evaluated for proper application. The data generated by such studies could substantiate evidence-based rehabilitation strategies for patients with aphasia. | Fabricio Ferreira de Oliveira Sheilla de Medeiros Correia Marin Paulo Henrique Ferreira Bertolucci | 2013 | Neural Regeneration Research2013，8，13： | 2 |
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