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| 1 | Association of interleukin-10 polymorphisms with risk of irritable bowel syndrome:A meta-analysis显示文摘AIM:To clarify the current understanding of the association between interleukin-10(IL-10)polymorphisms and the risk of irritable bowel syndrome(IBS).METHODS:We searched for studies in any language recorded in PubMed,Embase and Cochrane library before August 2013.The associations under allele contrast model,codominant model,dominant model,and recessive model were analyzed.The strengths of the association between IL-10 polymorphisms and IBS risk were estimated using odds ratios(OR)with 95%confidence interval(CI).Fixed effects model was used to pool the result if the test of heterogeneity was not significant,otherwise the random-effect model was selected.RESULTS:Eight case-control studies analyzing three single-nucleotide polymorphisms rs1800870(-1082 A/G),rs1800871(-819C/T),and rs1800872(-592A/C)of the IL-10 gene,which involved 928 cases and 1363 controls,were eligible for our analysis.The results showed that rs1800870 polymorphisms were associated with a decreased risk of IBS(GG+GA vs AA:OR=0.80,95%CI:0.66-0.96),(AA+GA vs GG:OR=0.68,95%CI:0.52-0.90).Subgroup analysis revealed such association only existed in Caucasian ethnicity(AA+GA vs GG,OR=0.70,95%CI:0.55-0.89).The rs1800872 polymorphisms were associated with an increased risk of IBS in Asian ethnicity(CC vs GG:OR=1.29,95%CI:1.01-1.16).There were no associations between rs1800871 polymorphisms and the IBS risk.CONCLUSION:The results suggest that IL-10 rs1800870confers susceptibility to the risk of IBS in Caucasian ethnicity,and the rs1800872 may associate with IBS risk in Asians.However,no significant associations are found between rs1800871 and IBS risk. | Shan-Yu Qin Hai-Xing Jiang Dong-Hong Lu You Zhou | 2013 | World Journal of Gastroenterology2013，19，48： | 7 |
| 2 | IL-8基因-251T/A和+781C/T多态性与南通地区肝癌遗传易感性的关联研究显示文摘目的了解南通地区人群白细胞介素8(IL-8)基因启动子区(rs4073)、第1内含子区(rs2227306)位点寡核苷酸多态性(SNP)的分布特点,探讨上述位点各基因型及联合基因型与肝细胞癌(HCC)患病风险的关系,分析各基因型与不同暴露因素在HCC发生中的相互作用。方法采用病例对照研究方法,利用限制性片段长度多态性聚合酶链反应(RFLP-PCR)技术对454例肝癌患者及446名健康对照者IL-8基因-251位点和+781位点进行基因分型。结果 1-251位点杂合突变基因型AT者罹患HCC的风险增加(OR=1.99,95%CI:1.01-3.85),+781位点突变基因型CT、TT者罹患HCC的风险增加(CT基因型OR=1.78,95%CI:1.03-3.10;TT基因型OR=1.36,95%CI:1.01-2.62)。2携带-251、+781两位点AT-CT、TT-CT及AT-CC联合基因型的个体罹患HCC的风险增加(AT-CT联合基因型OR=2.10,95%CI:1.52-2.90;TT-CT联合基因型OR=3.33,95%CI:1.01-10.50;AT-CC联合基因型OR=3.67,95%CI:2.28-5.90)。3-251位点SNP与饮酒、HBV感染、肝癌家族史因素在HCC的发生中存在正交互作用,该位点SNP与年龄、性别、吸烟因素在HCC的发生中存在负交互作用;+781位点SNP与饮酒、肝癌家族史因素在HCC的发生中存在正交互作用,该位点SNP与年龄、性别、吸烟、HBV感染因素在HCC的发生中存在负交互作用。结论南通地区人群IL-8基因-251、+781位点寡核苷酸多态性与HCC患病风险存在关联,并与不同暴露因素在HCC发生中存在交互作用。 | 陆小华 朱小庆 张玉宇 储玉山 茅国新 | 2015 | 介入放射学杂志2015，24，4： | 2 |
| 3 | 白细胞介素10-819C/T多态性和幽门螺杆菌感染在胃癌中交互作用研究显示文摘目的:探讨恩施人群IL-10-819C/T多态性与胃癌关联性及其与幽门螺杆菌感染交互作用。方法采用多聚酶链反应-限制性片段长度多态性( PCR-RFLP)方法分析142例胃癌患者和136名正常对照IL-10-819C/T基因型。纯合突变型( TT)为170bp、25bp,杂合基因型( CT)为195 bp、170 bp,野生基因型( CC)为195 bp。分析各基因型与发病中易感性关系以及与幽门螺杆菌感染的交互作用。采用SPSS19.0进行分析。基因型和等位基因频率比较采用非条件Logistic回归分析,基因型Hardy-Weinberg平衡法χ2检验。计量资料符合正态分布则采用( x-±s)表示,用t检验;以P<0.05为差异具有统计学意义。结果非条件Logistic分析表明认携带CC/CT基因型幽门螺杆菌感染个体胃癌罹患风险是携带TT基因非幽门螺杆菌感染个体的3.33倍( OR=3.33,95%CI:2.34,5.01, P=0.000)(RERI=1.66,95%CI:1.27,2.19;API=0.49,95%CI:0.36,0.79; S=1.27,95%CI:1.11,1.94)。结论 IL-10-819C/T多态性增加恩施地区胃癌罹患风险,且与幽门螺杆菌感染存在胃癌发病中存在协同效应。 | 马兵 黎磊 | 2016 | 中华普外科手术学杂志(电子版)2016，10，3： | 2 |
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