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| 1 | Effectiveness of contrast-enhanced harmonic endoscopic ultrasound for the evaluation of solid pancreatic masses显示文摘AIM:To evaluate the usefulness of contrast-enhanced harmonic endoscopic ultrasound(CH-EUS)in differentiating between pancreatic adenocarcinomas and other pancreatic disease.METHODS:This retrospective cohort study evaluated90 patients who were seen between November 2010and May 2013.All these patients had solid pancreatic masses that had a hypoechoic appearance on EUS.All patients underwent CH-EUS to evaluate this diagnostic method’s usefulness.The mass lesions observed on CH-EUS were classified into three categories based on their echo intensity:hypoenhanced,isoenhanced,and hyperenhanced lesions.We adjusted the sensitivity and the specificity of each category for detecting malignancies.We also estimated the accuracy of CH-EUS by comparing it to a pathological diagnosis.RESULTS:Of the 90 patients,62 had a pancreatic adenocarcinoma.Fifty-seven out of 62 pancreatic adenocarcinomas showed a hypoenhanced pattern on CHEUS.The sensitivity was 92%,the specificity 68%and the accuracy approximately 82%.The area under the curve of the receiver operating characteristic analysis for CH-EUS was 0.799.There is a significant association between the hypoenhanced pattern on CH-EUS and pancreatic duct adenocarcinoma(χ2=35.264,P<0.001).In pathological examinations,the number of specimens for EUS-fine needle aspiration(EUS-FNA)was considered insufficient for diagnosis in three patients,and in two patients,the results were reported to be negative for malignancy.Pancreatic masses in all five patients revealed a hypoenhanced pattern with CH-EUS.Three patients were diagnosed with pancreatic adenocarcinoma based on the pathology results of a biopsy,and the remaining two patients were clinically diagnosed with malignancy.CONCLUSION:CH-EUS is useful for distinguishing between pancreatic adenocarcinoma and other pancreatic disease.When a pancreatic mass shows a hypoenhanced pattern on CH-EUS but involves either insufficient samples or negative results with EUS-FNA,clinicians might consider performing another pathologic diagnosis on the basis of an EUS-FNA sample or a biopsy. | Jin-Seok Park Hyung Kil Kim Byoung Wook Bang Sang Gu Kim Seok Jeong Don Haeng Lee | 2014 | World Journal of Gastroenterology2014，20，2： | 7 |
| 2 | 超声内镜对比增强与弹性成像在胰腺癌诊断中的意义显示文摘超声内镜结合了内镜技术与超声技术,在其基础上衍生出超声内镜对比增强和弹性成像等新技术。目前,大量研究显示,相比于传统影像学技术,超声内镜对比增强在发现胰腺癌原发灶、判断是否合并局部血管侵犯、淋巴结转移及肝脏转移等方面具有传统影像学不可替代的优势,可为胰腺癌,特别是小胰腺癌的诊断、TNM分期以及明确根治性手术适应证等方面提供重要依据。超声内镜弹性成像亦可做为胰腺癌诊断的重要辅助手段。此外,在超声内镜引导下可以行细针穿刺活检,获取病理学标本。 | 叶童 宗晔 冀明 张澍田 赵海英 李鹏 | 2021 | 中国实用内科杂志2021，41，5： | 4 |
| 3 | Endoscopic ultrasound in gastroenterology:From diagnosis to therapeutic implications显示文摘Since its advent in 1980,the scope of endoscopic ultrasound(EUS)has grown to include a wide range of indications,and it is now being incorporated as an integral part of everyday practice in the field of gastroenterology.Its use is extending from an adjuvant imaging aid to utilization as a therapeutic tool for various gastrointestinal disorders.EUS was first used to visualize remote organs,such as the pancreas and abdominal lymph nodes.When fine needle aspiration was introduced,the indications for EUS expanded to include tissue sampling for diagnostic purposes.At the same time,the needle can be used to convey a potential therapy to the internal organs,allowing access to remote sites.In this review,we aim to highlight the expanding spectrum of EUS indications and uses in the field of gastroenterology. | Mohamed A Mekky Wael A Abbas | 2014 | World Journal of Gastroenterology2014，20，24： | 4 |
| 4 | 造影增强内镜超声在胰腺囊性病变中的应用显示文摘胰腺囊性病变(pancreatic cystic lesions,PCLs)分非肿瘤性和肿瘤性两类,非肿瘤性主要为胰腺假性囊肿(pancreatic pseudocysts,PPs),肿瘤性包括浆液性囊性肿瘤(serous cystic neoplasm,SCN)、黏液性囊性肿瘤(mucinous cystic neoplasm,MCN)、导管内乳头状黏液瘤(intraductal papillary mucinous neoplasm,IPMN)、实性假乳头状瘤(solid pseudopapillary neoplasm,SPN)等。 | 孙金山 周益峰 金震东 李兆申 | 2014 | 中华消化内镜杂志2014，31，8： | 1 |
| 5 | 内镜在胆胰系统疾病诊治中的应用显示文摘随着人们生活水平的提高,微创、快速康复的医疗理念逐渐深入人心。自从1968年内镜下逆行胆胰管造影术(ERCP)问世以来,尤其是1974年内镜下乳头括约肌切开术(EST)的临床应用,ERCP已成为临床诊断和治疗胆胰疾病的重要手段,近年来,胆道镜、胆道母子镜以及超声内镜在胆胰系统疾病中的应用也日益广泛,以上技术在临床上联合应用、相互补充,进一步确定了内镜在胆胰系统疾病中诊断及治疗中难以取代的巨大作用。本文将简述内镜在胆胰系统疾病诊治中的应用现状。 | 周文策 李玉民 王正峰 | 2015 | 医院与医学2015，3，1： | 1 |
| 6 | Imaging techniques used for the real-time assessment of angiogenesis in digestive cancers显示文摘Angiogenesis has a critical role in primary tumor growth and the development of metastases.Several angiogenesis inhibitors were recently developed,being a very attractive target for digestive tumor therapy.However,individualized therapy should not only be based on the pre-treatment imaging evaluation,but also on sensitive monitoring of microvascular changes during treatment.State-of-theart imaging techniques have the potential to visualize and characterize angiogenesis,although the technology and methodologies employed are recent and need further validation.The aim of this series of reviews was to analyze and enhance current knowledge and future perspectives about the real-time assessment of angiogenesis in digestive cancers,used for the longitudinal monitoring of the effects of chemo-radiotherapy(including anti-angiogenic therapies),as well as for the precise targeting of drugs through molecular-based drug-delivery systems. | Adrian Sǎftoiu Peter Vilmann | 2011 | World Journal of Gastroenterology2011，17，1： | 0 |
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