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| 1 | 免疫佐剂研究进展及前景展望显示文摘本文从免疫佐剂的发现、作用机理、发展进行论述,综述了传统免疫佐剂、细胞因子佐剂、天然来源佐剂及新型免疫佐剂的类别与免疫机理,并就免疫佐剂的发展前景进行了展望。 | 李学钊 洪炀 王治仓 李祥瑞 宋鸿雁 | 2014 | 中国动物传染病学报2014，22，4： | 22 |
| 2 | 天花粉中总三萜皂苷的含量分析显示文摘目的:对天花粉中总三萜皂苷含量进行测定,为天花粉质量评价提供依据。方法:选用熊果酸为对照品,5%香草醛-冰醋酸和高氯酸为显色剂,以紫外分光光度法测定天花粉中总三萜皂苷的含量。结果:标品在16~48μg范围内有良好的线性关系(r=0.9905)。样品在10~40min内稳定,加样回收率为97.22%,RSD=1.59。结论:该方法操作简便,快速,灵敏度高和重复性好,可用于天花粉及其相关产品的质量控制。 | 陈颖 董孝刚 孟丽 孙海燕 曹银萍 | 2010 | 中国野生植物资源2010，29，4： | 9 |
| 3 | Ginsenosides stimulated the proliferation of mouse spermatogonia involving activation of protein kinase C显示文摘The effect of ginsenosides on proliferation of type A spermatogonia was investigated in 7-day-old mice. Spermatogonia were characterized by c-kit expression and cell proliferation was assessed by immunocytochemical demonstration of proliferating cell nuclear antigen (PCNA). After 72-h culture, Sertoli cells formed a confluent monolayer to which numerous spermatogonial colonies attached. Spermatogonia were positive for c-kit staining and showed high proliferating activity by PCNA expression. Ginsenosides (1.0~10 μg/ml) significantly stimulated proliferation of spermatogonia. Activation of protein kinase C (PKC) elicited proliferation of spermatogonia at 10-8 to 10-7 mol/L and the PKC inhibitor H7 inhibited this effect. Likewise, ginsenosides-stimulated spermatogonial proliferation was suppressed by combined treatment of H7. These results indicate that the proliferating effect of ginsenosides on mouse type A spermatogonia might be mediated by a mechanism involving the PKC signal transduction pathway. | Da-lei ZHANG Kai-ming WANG Cai-qiao ZHANG | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，2： | 5 |
| 4 | 白术对猪O型口蹄疫疫苗免疫效果及抗氧化性的影响显示文摘为提高猪O型口蹄疫疫苗的免疫效果,将试验猪分为5组,在免疫口蹄疫疫苗前分别饲喂基础日粮、添加了0.5%粉碎白术、1.0%粉碎白术、0.5%煎煮白术、1.0%煎煮白术的试验日粮,然后对各组猪进行口蹄疫的常规免疫,首免前和二免后3周后分别采血测定口蹄疫抗体水平.结果表明,首免前各试验组猪与对照组相比,除饲喂1.0%粉碎白术组外,口蹄疫抗体水平与对照组相比差异均不显著(P>0.05),且低于试剂盒0.4的阳性标准,二免后3周的测定结果表明,0.5%水平的粉碎白术和0.5%煎煮白术均较对照组显著提高了口蹄疫的抗体水平(P<0.05),试验中未见明显不良反应,对试验猪体增重的影响也不大;此外,首免前饲喂1.0%粉碎白术组的抗体水平均值为0.409,高于试剂盒0.4的阳性标准,且显著高于对照组(P<0.05),二免后3周该组的均值为0.384,低于试剂盒0.4的阳性标准,与对照组差异不显著(P>0.05).总之,0.5%的煎煮或粉碎白术添加到基础日粮饲喂10 d,可显著提高O型口蹄疫疫苗二免后3周的口蹄疫抗体水平,生产中母源抗体对口蹄疫疫苗免疫失败的影响也值得重视. | 李瑞丽 严寒 郑小明 万明春 | 2019 | 猪业科学2019，36，8： | 1 |
| 5 | Ethnobotanical review and pharmacological properties of selected medicinal plants in Brunei Darussalam:Litsea elliptica,Dillenia suffruticosa,Dillenia excelsa,Aidia racemosa,Vitex pinnata and Senna alata显示文摘The aim of the current study is to review the medicinal properties of the plants found in Brunei Darussalam namely Litsea elliptica, Dillenia suffruticosa, Dillenia excelsa, Aidia racemosa, Vitex pinnata and Senna alata. The known phytochemical constituents of these plants and their ability to bring about a range of biological activities are included in this review. These plants have been used traditionally for a multitude of diseases and illnesses. There is a lot of untapped potential in these medicinal plants which could cure multiple diseases. | May Poh Yik Goh Aida Maryam Basri Hartini Yasin Hussein Taha Norhayati Ahmad | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，2： | 0 |
| 6 | Multidisciplinary perspectives on mechanisms of activity of popular immune-enhancing herbal supplements used by athletes显示文摘这份报纸检验可以支撑的细胞、分子的机制在运动员免疫者的上下文的五草药的补充的声称的效果工作。人参和 echinacea 被运动员经常使用,而距骨和接骨木不经常被使用, pequi 就作为可能的补充正在出现。在这些的 vivo 研究,运动员免疫者功能上的产品产出异构的结果,由于试验性的设计差别可能。人参, echinacea,接骨木,和 pequi 被认为海盘车 sensu lato。人参看起来在适应免疫, CD4+T 房间的特别地维持的 Th1/Th2 平衡和他们的下游的效果的部件上施加最强壮的效果,经由它的人参皂甙, flavonoids,和多糖。Echinacea alkamides,咖啡的酸衍生物,和 polysacchardies 可以指向天生、适应的免疫,尽管也许前者更一致地。接骨木怀有可以调制天生的免疫的 anthocyanins 和 lectins。pequi 上的数据被限制,但是建议类胡萝卜素,酚,和丰满的酸可以改变传播白血球人口。更种系发生地远,距骨是 rosid sensu lato 并且可以通过 flavonoids,多糖,和 saponins 影响天生的免疫系统。补充通常不在生理的参数例如上表明效果喂奶,氧动力学,或运动性能。Bioavailability 研究显示那声称这些补充的 bioactive 分子可以在低却 therapeutically 相关的数量到达循环。在 crosscomparisons 的困难由于学习设计差别,结合了关于话题的研究的全面缺乏,当前为运动员作为 immunoregulators 关于这些补充的功效妨碍任何正式结论。 | David S. SENCHINA Justus E. HALLAM David J. CHENEY | 2013 | Frontiers in Biology2013，8，1： | 0 |
| 7 | Investigation on Prescription Screening of a Polyherbal Preparation Based on Splenocyte Proliferation Activity and its Preparation Method显示文摘Objective: The present study aims to optimize the extraction conditions of polysaccharides and flavonoids from a polyherbal preparation consisting of three kinds of Chinese medicinal herbs, Codonopsis pilosula, Crataegus pinnatifida, and Lycium barbarum, and evaluation of its immunomodulatory activity in immunosuppressed mice. Materials and Methods: An orthogonal design(L_9 [3]~4) was constructed to achieve the optimal extraction conditions. The immunomodulatory action of the polyherbal preparation was studied at three doses of 10, 20, and 40 mL/kg/day orally by measuring splenocyte proliferation in mice model of cyclophosphamide-induced immunosuppression. Results: The chosen parameters, including the ratio of solvent-to-raw material, duration of extraction, and extraction times, were the fundamental variables that influenced the extract yields. The highest yield of total polysaccharides content was 54.3 mg/mL when the ratio of solvent-to-raw material,duration of extraction, and number of extractions were 12:1, 1.5 h, and 3, respectively. The maximum extraction yield of the flavonoids was 3.5 mg/mL when the ratio of solvent-to-raw material was 12:1, the extraction time was 2 h, and the number of extractions was 3. The prescription screening showed that the impact of the polyherbal preparation on the splenocyte proliferation capacity was more pronounced than its disassembled components. Oral administration of the polyherbal preparation could significantly increase the concanavalin A-stimulated mouse spleen cells proliferation in a dose-dependent manner. Conclusion: These findings suggested that the polyherbal preparation possesses potential for augmenting the immune activity due to the polysaccharide and flavonoid content in these herbal medicines. | Ahmed Attia Ahmed Abdelmoaty Yu-Ling Ma Ruibin Bai Xiao-Ping Zheng Fang-Di Hu Ying-Dong Li | 2017 | World Journal of Traditional Chinese Medicine2017，3，4： | 0 |
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