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| 1 | Clinical outcomes of combined flow-pressure drop measurements using newly developed diagnostic endpoint:Pressure drop coefficient in patients with coronary artery dysfunction显示文摘AIM:To combine pressure and flow parameter, pressure drop coefficient(CDP) will result in better clinical outcomes in comparison to the fractional flow reserve(FFR) group. METHODS:To test this hypothesis, a comparison was made between the FFR < 0.75 and CDP > 27.9 groups in this study, for the major adverse cardiac events [major adverse cardiac events(MACE): Primary outcome] and patients’ quality of life(secondary outcome). Further, a comparison was also made between the survival curves for the FFR < 0.75 and CDP > 27.9 groups. Two-tailed χ~2 test proportions were performed for the comparison of primary and secondary outcomes. Kaplan-Meier survival analysis was performed to compare the survival curves of FFR < 0.75 and CDP > 27.9 groups(MedcalcV10.2, Mariakerke, Belgium). Results were considered statistically significant for P < 0.05. RESULTS: The primary outcomes(%MACE) in the FFR < 0.75 group(20%, 4 out of 20) was not statistically different(P = 0.24) from the %MACE occurring in CDP > 27.9 group(8.57%, 2 out of 35). Noteworthy is the reduction in the %MACE in the CDP > 27.9 group, in comparison to the FFR < 0.75 group. Further, the secondary outcomes were not statistically significant between the FFR < 0.75 and CDP > 27.9 groups. Survival analysis results suggest that the survival time for the CDP > 27.9 group(n = 35) is significantly higher(P = 0.048) in comparison to the survival time for the FFR < 0.75 group(n = 20). The results remained similar for a FFR = 0.80 cut-off. CONCLUSION: Based on the above, CDP could prove to be a better diagnostic end-point for clinical revascularization decision-making in the cardiac catheterization laboratories. | Mohamed A Effat Srikara Viswanath Peelukhana Rupak K Banerjee | 2016 | World Journal of Cardiology2016，8，3： | 2 |
| 2 | 压力导丝在冠状动脉介入诊治中的应用优势显示文摘临床中,冠心病是一种较为常见的慢性病,CAG(冠状动脉造影)技术视为作为评估冠心病严重程度的主要标准[2,3]。如果冠状动脉造影显示为冠状动脉有严重病变或者是正常情况,冠状动脉造影结果明确,可以指导冠状动脉介入治疗或者是药物治疗,但需要注意的是冠脉造影在判断冠状动脉交界性病变方面有着一定的局限性。冠状动脉造影通常情况下只能显示出造影剂填充的管腔轮廓,并且间接反映患者血管病变,但无法提供功能方面的信息[4]。最近几年以来, | 高丽华 夏禹华 胡庆鹰 王智慧 | 2016 | 中国实验诊断学2016，20，8： | 2 |
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