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| 1 | 实时组织弹性成像肝纤维化指数在慢性乙型肝炎患者中的应用价值显示文摘目的评估实时组织弹性成像在慢性乙型肝炎患者中的应用价值。方法选取2013年5月至2015年4月122例健康志愿者、107例慢性乙型肝炎患者、92例肝硬化患者进行实时组织弹性成像检查,采用组织弥散定量分析软件,得到多个定量弹性参数。采用单因素方差分析各弹性参数的组间差异,Spearman等级相关分析弹性参数与疾病严重程度的关系,构建受试者工作特征曲线,评估诊断效能。结果健康对照组、慢性肝炎组、肝硬化组三组间比较,应变均值(MEAN)、标准差(SD)、蓝色区域面积比(AREA%)、复杂度(COMP)、峰度(KURT)、偏度(SKEW)、对比度(CONT)、均等性(ENT)、杂乱度(IDM)、相关性(CORR)、肝纤维化指数(LF index)等多个弹性参数差异均具有显著统计学意义(P<0.01);其中LF index、AREA%、COMP、SD与病情程度呈高度相关(|r|≥0.7);LF index诊断慢性肝炎及肝硬化的受试者工作特征曲线下面积分别为0.874(0.836~0.913)和0.922(0.887~0.949)。结论实时组织弹性成像在慢性乙型肝炎患者中具有较好的应用价值。 | 李开林 农华斌 冯霞 江堤 黄小平 吴向东 方北 | 2016 | 海南医学2016，27，7： | 3 |
| 2 | New horizon for radical cure of chronic hepatitis B virus infection显示文摘About 250 to 350 million people worldwide are chronically infected with hepatitis B virus(HBV), and about 700000 patients per year die of HBV-related cirrhosis or hepatocellular carcinoma(HCC). Several anti-viral agents, such as interferon and nucleos(t)ide analogues(NAs), have been used to treat this disease. NAs especially have been shown to strongly suppress HBV replication, slowing the progression to cirrhosis and the development of HCC. However, reactivation of HBV replication often occurs after cessation of treatment, because NAs alone cannot completely remove covalentlyclosed circular DNA(ccc DNA), the template of HBV replication, from the nuclei of hepatocytes. Anti-HBV immune responses, in conjunction with interferon-γ and tumor necrosis factor-α, were found to eliminate ccc DNA, but complete eradication of ccc DNA by immune response alone is difficult, as shown in patients who recover from acute HBV infection but often show long-term persistence of small amounts of HBV-DNA in the blood. Several new drugs interfering with the life cycle of HBV in hepatocytes have been developed, with drugs targeting ccc DNA theoretically the most effective for radical cure of chronic HBV infection. However, the safety of these drugs should be extensively examined before application to patients, and combinations of several approaches may be necessary for radical cure of chronic HBV infection. | Kazuto Tajiri Yukihiro Shimizu | 2016 | World Journal of Hepatology2016，8，21： | 1 |
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