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| 1 | 乙型和丙型肝炎后肝硬化与糖尿病的关系显示文摘乙型肝炎后肝硬化和丙型肝炎后肝硬化与糖尿病密切相关。一方面,乙型肝炎后肝硬化和丙型肝炎肝硬化会导致糖尿病,此类糖尿病为肝源性糖尿病。另一方面,糖尿病又会导致慢性乙型肝炎和慢性丙型肝炎进展为肝硬化,并使其进一步发生发展。且导致肝硬化并发症(感染、肝性脑病等)的发生率及病死率升高,同时糖尿病可能与乙型肝炎后肝硬化和丙型肝炎后肝硬化进展为肝癌密切相关。 | 李月月 陈青锋 | 2016 | 医学综述2016，22，10： | 4 |
| 2 | Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C显示文摘AIM: To clarify the characteristics of metabolite profiles in virus-related hepatocellular carcinoma(HCC) patients using serum metabolome analysis. METHODS: The serum levels of low-molecular-weight metabolites in 68 patients with HCC were quantified using capillary electrophoresis chromatography and mass spectrometry. Thirty and 38 of the patients suffered from hepatitis B virus-related HCC(HCC-B) and hepatitis C virus-related HCC(HCC-C), respectively.RESULTS: The main metabolites characteristic of HCC were those associated with glutathione metabolism, notably 13 γ-glutamyl peptides, which are by-products of glutathione induction. Two major profiles, i.e., concentration patterns, of metabolites were identified in HCC patients, and these were classified into two groups: an HCC-B group and an HCC-C group including some of the HCC-B cases. The receiver operating characteristic curve for the multiple logistic regressionmodel discriminating HCC-B from HCC-C incorporating the concentrations of glutamic acid, methionine and γ-glutamyl-glycine-glycine showed a highly significant area under the curve value of 0.94(95%CI: 0.89-1.0, P < 0.0001).CONCLUSION: The serum levels of γ-glutamyl peptides, as well as their concentration patterns, contribute to the development of potential biomarkers for virus-related HCC. The difference in metabolite profiles between HCC-B and HCC-C may reflect the respective metabolic reactions that underlie the different pathogeneses of these two types of HCC. | Takafumi Saito Masahiro Sugimoto Kazuo Okumoto Hiroaki Haga Tomohiro Katsumi Kei Mizuno Taketo Nishina Sonoko Sato Kaori Igarashi Hiroko Maki Masaru Tomita Yoshiyuki Ueno Tomoyoshi Soga | 2016 | World Journal of Gastroenterology2016，22，27： | 0 |
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