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| 1 | Value of screening endoscopy in evaluation of esophageal,gastric and colon cancers显示文摘Esophageal,gastric,and colorectal cancers are deadly diseases that continue to plague our world today.The value of screening endoscopy in evaluating these types of cancers is a critical area of discussion due to a potential reduction in morbidity and mortality.This article describes how to identify a good screening test and explains what are important criteria in the field of screening endoscopy.Furthermore,the current status and progress of screening endoscopy for esophageal,gastric,and colorectal cancer will be evaluated and discussed.Mass screening programs have not been implemented for esophageal and gastric carcinomas in those with average or low risk populations.However,studies of high-risk populations have found value and a cost-benefit in conducting screening endoscopy.Colorectal cancer,on the other hand,has had mass screening programs in place for many years due to the clear evidence of improved outcomes.As the role of endoscopy as a screening tool has continued to develop,newer technology and techniques have emerged to improve its utility.Many new image enhancement techniques and computer processing programs have shown promise and may have a significant role in the future of endoscopic screening.These developments are paving the way for improving the diagnostic and therapeutic capability of endoscopy in the field of gastroenterology. | Tae H Ro Michelle A Mathew Subhasis Misra | 2015 | World Journal of Gastroenterology2015，21，33： | 9 |
| 2 | Fecal DNA testing for colorectal cancer screening:molecular targets and perspectives显示文摘The early detection of colorectal cancer with effective screening is essential for reduction of cancer-specific mortality. The addition of fecal DNA testing in the armamentarium of screening methods already in clinical use launches a new era in the noninvasive part of colorectal cancer screening and emanates from a large number of previous and ongoing clinical investigations and technological advancements. In this review, we discuss the molecular rational and most important genetic alterations hallmarking the early colorectal carcinogenesis process. Also, representative DNA targets-markers and key aspects of their testing at the clinical level in comparison or/and association with other screening methods are described. Finally, a critical view of the strengths and limitations of fecal DNA tests is provided, along with anticipated barriers and suggestions for further exploitation of their use. | Amaninder Dhaliwal Panagiotis J Vlachostergios Katerina G Oikonomou Yitzchak Moshenyat | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 3 |
| 3 | Light and sound- emerging imaging techniques for inflammatory bowel disease显示文摘Patients with inflammatory bowel disease are known to have a high demand of recurrent evaluation for therapy and disease activity. Further, the risk of developing cancer during the disease progression is increasing from year to year. New, mostly non-radiant, quick to perform and quantitative methods are challenging, conventional endoscopy with biopsy as gold standard. Especially, new physical imaging approaches utilizing light and sound waves have facilitated the development of advanced functional and molecular modalities. Besides these advantages they hold the promise to predict personalized therapeutic responses and to spare frequent invasive procedures. Within this article we highlight their potential for initial diagnosis, assessment of disease activity and surveillance of cancer development in established techniques and recent advances such as wide-view full-spectrum endoscopy, chromoendoscopy, autofluorescence endoscopy, endocytoscopy, confocal laser endoscopy, multiphoton endoscopy, molecular imaging endoscopy, B-mode and Doppler ultrasound, contrast-enhanced ultrasound, ultrasound molecular imaging, and elastography. | Ferdinand Knieling Maximilian J Waldner | 2016 | World Journal of Gastroenterology2016，22，25： | 1 |
| 4 | How to improve colon cancer screening rates显示文摘Colorectal carcinoma is a common cause of death throughout the world and may be prevented by routine control, which can detect precancerous neoplasms and early cancers before they undergo malignant transformation or metastasis. Three strategies may improve colon cancer screening rates: convince the population about the importance of undergoing a screening test; achieve higher efficacy in standard screening tests and make them more available to the community and develop new more sensitive and efficacious screening methods and make them available as routine tests. In this light, the present study seeks to review these three means through which to increase colon cancer screening rates. | Luiz Ronaldo Alberti Diego Paim Carvalho Garcia Debora Lucciola Coelho David Correa Alves De Lima Andy Petroianu | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 1 |
| 5 | Feasibility of full-spectrum endoscopy:Korea's first full-spectrum endoscopy colonoscopic trial显示文摘AIM: To evaluate the full-spectrum endoscopy(FUSE) colonoscopy system as the first report on the utility thereof in a Korean population.METHODS: We explored the efficacy of the FUSE colonoscopy in a retrospective, single-center feasibility study performed between February 1 and July 20, 2015. A total of 262 subjects(age range: 22-80) underwent the FUSE colonoscopy for colorectal cancer screening, polyp surveillance, or diagnostic evaluation. The cecal intubation success rate, the polyp detection rate(PDR), the adenoma detection rate(ADR), and the diverticulum detection rate(DDR), were calculated. Also, the success rates of therapeutic interventions were evaluated with biopsy confirmation.RESULTS: All patients completed the study and the success rates of cecal and terminal ileal intubation were 100% with the FUSE colonoscope; we found 313 polyps in 142 patients and 173 adenomas in 95. The overall PDR, ADR and DDR were 54.2%, 36.3%, and 25.2%, respectively, and were higher in males, and increased with age. The endoscopists and nurses involved considered that the full-spectrum colonoscope improved navigation and orientation within the colon.No colonoscopy was aborted because of colonoscope malfunction.CONCLUSION: The FUSE colonoscopy yielded a higher PDR, ADR, DDR than did traditional colonoscopy, without therapeutic failure or complications, showing feasible, effective, and safe in this first Korean trial. | Jeong-Yeop Song Youn Hee Cho Mi A Kim Jeong-Ae Kim Chun Tek Lee Moon Sung Lee | 2016 | World Journal of Gastroenterology2016，22，8： | 0 |
| 6 | Expanding the view of a standard colonoscope with the Third Eye~ Panoramic^(TM) cap显示文摘AIM: To evaluate a new imaging device for colonoscopy that adds two side viewing CMOS lenses, the Third EyePanoramic. cap.METHODS: In this prospective observational feasibility study, 33 patients, 18 male and 15 female, underwent routine screening, surveillance or diagnostic colonoscopy with the new Third EyePanoramic. cap clipped on to the distal tip of a high definition Fuji EC530-LS Slim Colonoscope. All procedures were performed at the New York Presbyterian-Queens Endoscopy unit by two experienced endoscopists(Rubin M and Kim SH). Main outcome measurements included evaluation of the image quality of the Third EyePanoramic. cap, adenoma detection rate, cecal intubation rate, withdrawal time and total procedure time.RESULTS: The Third EyePanoramic. cap enabled enhanced views without affecting the quality of the colonoscope's image or its handling characteristics through the colon. Ileal intubation was accomplished in most cases, but was more challenging. The side view lenses detected polyps and diverticula hidden behind folds and in flexures not seen on the standard view.The side view lenses were easily cleaned utilizing an EndogatorIrrigation Pump(Medivators, Minneapolis,MN, United States) by angling the scope tip against the mucosa while washing. The cecum was reached in all33 patients. Mean cecal intubation time was 8.19 ± 2.17 min, mean withdrawal time was 10.15 ± 5.56 min and mean total procedure time was 20.31 ± 5.14 min. The overall adenoma detection rate was 44%.CONCLUSION: The Third EyePanoramic. cap enables wide view colonoscopy with enhanced visualization utilizing standard forward view colonoscopes. | Moshe Rubin Leigh Lurie Konika Bose Sang H Kim | 2015 | World Journal of Gastroenterology2015，21，37： | 0 |
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