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		题名	作者	年代	出处	被引量
	1	Translational research in pancreatic ductal adenocarcinoma: current evidence and future concepts显示文摘Pancreatic ductal adenocarcinoma(PDA) is one of the major causes for cancer death worldwide. Treatment of metastatic disease remains challenging as only certain patients benefit from advances made with the intensified chemotherapy regimen folinic acid, irinotecan and oxaliplatin, the epidermal growth factor receptor inhibitor erlotinib or the recently FDA-approved nab-paclitaxel. Up to date, no established approach for prediction of treatment response or specific treatment allocation exists. Translational research was able to identify a number of potential biomarkers that might help to improve the dismal prognosis of PDA by facilitating upfront treatment allocation. This topic highlight is focused on current evidence on potential biomarkers for tumor biology, prognosis and prediction of treatment efficacy.	Stephan Kruger Michael Haas Steffen Ormanns Sibylle Bchmann Jens T Siveke Thomas Kirchner Volker Heinemann Stefan Boeck	2014	World Journal of Gastroenterology2014，20，31：	1
	2	Pancreatic biomarkers:Could they be the answer?显示文摘Pancreatic ductal adenocarcinoma(PDA)is known for its poor prognosis.Most of the patients are diagnosed with advanced stages,when no curative treatment is available.Currently,despite extensive clinical research on PDA,the median overall survival remains short.Diagnosis delay and primary chemo-resistance due to its intrinsic biological nature may explain the challenges to improve our results.Our knowledge about the molecular biology of PDA has exponentially increased during the last decades and its use for the development of biomarkers could help to reach better results in the clinical setting.These biomarkers could be the clue for the improvement in PDA clinical research by earlier detection strategies with diagnostic biomarkers,and by an individualization of treatment approach with prognostic and predictive biomarkers.This review summarizes the current knowledge about the molecular biology of PDA and the status of the most important prognostic and predictive biomarkers.	Angela Lamarca Jaime Feliu	2014	World Journal of Gastroenterology2014，20，24：	0

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