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| 1 | Reduced expression of circulating microRNA-218 in gastric cancer and correlation with tumor invasion and prognosis显示文摘AIM:To investigate the expression of microRNA-218(miR-218)in serum from gastric cancer patients and its relationship with clinicopathological characteristics.METHODS:A total of 68 patients with pathologically diagnosed gastric cancer and 56 healthy individuals were recruited to this study.The expression of miR-218was detected in the serum of gastric cancer patients and healthy individuals by quantitative real-time polymerase chain reaction.The clinical data were collectedand analyzed by statistical software.RESULTS:miR-218 was reduced significantly in the serum of gastric cancer patients compared to healthy individuals(1.15±0.08 vs 0.37±0.023;P=0.026).In the gastric cancer group,serum expression of miR-218was lower in patients with metastasis and poorly differentiated cancer compared with non-metastatic and well-differentiated cancer(0.19±0.011 vs 0.45±0.021,P=0.031 and 0.21±0.019 vs 0.49±0.021,P=0.025).Serum miR-218 was found to be significantly associated with gastric cancer metastasis(P=0.003),tumor T stage(P=0.018)and tumor grade(P=0.012).Low serum expression of miR-218 was related to an increase in the stage of gastric cancer.The expression level of miR-218 in the serum was correlated with the3-year survival.Ninety-seven percent of patients with a high level of miR-218 expression survived for 3 years,while only 54%of those with low miR-218 expression survived.CONCLUSION:miR-218 is deregulated in gastric cancer patients and is strongly correlated with tumor stage,grade and metastasis.Serum expression of miR-218 may be a prognostic marker. | Shi-Yong Xin Xiao-Shan Feng Li-Qing Zhou Jun-Jun Sun Xiao-Le Gao Guo-Liang Yao | 2014 | World Journal of Gastroenterology2014，20，22： | 11 |
| 2 | MicroRNA-218在肿瘤中的研究进展显示文摘微小RNA(microRNA,miRNA)是一类内源性非编码小RNA,可调控不同基因的表达,从而改变细胞和生物体的表型。微小RNA-218(MicroRNA-218,miR-218)的异常表达可导致细胞的增殖、分化、凋亡异常,与肿瘤的发生发展及预后密切相关。本文简述了miR-218与女性生殖系统肿瘤、消化道肿瘤、颅内肿瘤、呼吸道肿瘤、泌尿生殖系肿瘤之间的关系,拟出miR-218可能的调控机制,有助于为肿瘤的诊断和治疗提供新的靶点。 | 龙倩 周航 | 2016 | 大家健康(学术版)2016，，8： | 2 |
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