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| 1 | Ever-changing endoscopic treatment for early gastric cancer:Yesterday-today-tomorrow显示文摘Endoscopic resection has been an optimal treatment for selected patients with early gastric cancer(EGC) based on advances in endoscopic instruments and techniques. As endoscopic submucosal dissection(ESD) has been widely used for treatment of EGC along with expanding ESD indication, concerns have been asked to achieve curative resection for EGC while guaranteeing precise prediction of lymph node metastasis(LNM). Recently, new techniques including ESD or endoscopic full-thickness resection combined with sentinel node navigation enable minimal tumor resection and a laparoscopic lymphadenectomy in cases of EGC with high risk of LNM. This review covers the development and challenges of endoscopic treatment for EGC. Moreover, a new microscopic imaging and endoscopic techniques for precise endoscopic diagnosis and minimally invasive treatment of EGC are introduced. | Mi-Young Kim Jun-Hyung Cho Joo Young Cho | 2014 | World Journal of Gastroenterology2014，20，37： | 21 |
| 2 | New approaches to gastric cancer staging:Beyond endoscopic ultrasound,computed tomography and positron emission tomography显示文摘Currently,there is no single gold standard modality for staging of gastric cancer and several methods have been used complementarily in the each clinical situation. To make up for the shortcomings of conventional modalities such as endoscopic ultrasound,computed tomography and 18F-fluoro-2-deoxyglucose positron emission tomography,numerous attempts with new approaches have been made for gastric cancer staging. For T staging,magnifying endoscopy with narrow-band was evaluated to differentiate mucosal cancer from submucosal cancer. Single/double contrast-enhanced ultrasound and diffusion-weighted magnetic resonance imaging were also tried to improve diagnostic accuracy of gastric cancer. For intraoperative staging with sentinel node mapping,indocyanine green infrared and fluorescence imaging was introduced. In addition,to detect micrometastasis,real-time reverse transcription-polymerase chain reaction system with multiple markers was studied.Staging laparoscopy using 5-aminolevulinic acid-mediated photodynamic diagnosis and percutaneous diagnostic peritoneal lavage were also evaluated.However,most studies reporting new staging methods is preliminary and further studies for validation in clinical practice are needed.In this mini-review,we discuss new progress in gastric cancer staging.Especially,we focus on new diagnostic approach to gastric cancer staging beyond the conventional modalities and briefly review the remarkable clinical results of the studies published over the past three years. | Hyuk Yoon Dong Ho Lee | 2014 | World Journal of Gastroenterology2014，20，38： | 17 |
| 3 | Endoscopic submucosal dissection for undifferentiated-type early gastric cancer: Do we have enough data to support this?显示文摘Although endoscopic submucosal dissection(ESD)is now accepted for treatment of early gastric cancers(EGC)with negligible risk of lymph node(LN)metastasis,ESD for intramucosal undifferentiated type EGC without ulceration and with diameter≤2 cm is regarded as an investigational treatment according to the Japanese gastric cancer treatment guidelines.This consideration was largely based on the analysis of surgically resected EGCs that contained undifferentiated type EGCs;however,results from several institutes showed some discrepancies in sample size and incidence of LN metastasis.Recently,some reports about the safety and efficacy of ESD for undifferentiated type EGC meeting the expanded criteria have been published.Nonetheless,only limited data are available regarding long-term outcomes of ESD for EGC with undifferentiated histology so far.At the same time,endoscopists cannot ignore the patients’desire to guarantee quality of life after the relatively non-invasive endoscopic treatment when compared to conventional surgery.To satisfy the needs of patients and provide solid evidence to support ESD for undifferentiated EGC,we need more delicate tools to predict undetected LN metastasis and more data that can reveal predictive factors for LN metastasis. | Choong Nam Shim Sang Kil Lee | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 4 | Sentinel lymph node navigation surgery for gastric cancer: Does it really benefit the patient?显示文摘Sentinel lymph node(SLN) navigation surgery is accepted as a standard treatment procedure for malignant melanoma and breast cancer. However, the benefit of reduced lymphadenectomy based on SLN examination remains unclear in cases of gastric cancer. Here, we review previous studies to determine whether SLN navigation surgery is beneficial for gastric cancer patients. Recently, a large-scale prospective study from the Japanese Society of Sentinel Node Navigation Surgery reported that the endoscopic dual tracer method, using a dye and radioisotope for SLN biopsy, was safe and effective when applied to cases of superficial and relatively small gastric cancers. SLN mapping with SLN basin dissection was preferred for early gastric cancer since it is minimally invasive. However, previous studies reported that limited gastrectomy and lymphadenectomy may not improve the patient's postoperative quality of life(QOL). As a result, the benefit of SLN navigation surgery for gastric cancer patients, in terms of their QOL, is limited. Thus, endoscopic and laparoscopic limited gastrectomy combined with SLN navigation surgery has the potential to become the standard minimally invasive surgery in early gastric cancer. | Tohru Tani Hiromichi Sonoda Masaji Tani | 2016 | World Journal of Gastroenterology2016，22，10： | 6 |
| 5 | Cutting edge of endoscopic full-thickness resection for gastric tumor显示文摘Recently,several studies have reported local full-thickness resection techniques using flexible endoscopy for gastric tumors,such as gastrointestinal stromal tumors,gastric carcinoid tumors,and early gastric cancer(EGC). These techniques have the advantage of allowing precise resection lines to be determined using intraluminal endoscopy. Thus,it is possible to minimize the resection area and subsequent deformity. Some of these methods include:(1) classical laparoscopic and endoscopic cooperative surgery(LECS);(2) inverted LECS;(3) combination of laparoscopic and endoscopic approaches to neoplasia with non-exposure technique; and(4) non-exposed endoscopic wall-inversion surgery. Furthermore,a recent prospective multicenter trial of the sentinel node navigation surgery(SNNS) for EGC has shown acceptable results in terms of sentinel node detection rate and the accuracy of nodal metastasis. Endoscopic full-thickness resection with SNNS is expected to become a treatment option that bridges the gap between endoscopic submucosal dissection and standard surgery for EGC. In the future,the indications for these procedures for gastric tumors could be expanded. | Tadateru Maehata Osamu Goto Hiroya Takeuchi Yuko Kitagawa Naohisa Yahagi | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，16： | 4 |
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