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| 1 | Correlation between blood pressure changes and AMS, sleeping quality and exercise upon high-altitude exposure in young Chinese men显示文摘Background: Excessive elevation of arterial blood pressure(BP) at high altitude can be detrimental to our health due to acute mountain sickness(AMS) or some AMS symptoms. This prospective and observational study aimed to elucidate blood pressure changes induced by exposure to high-altitude hypoxia and the relationships of these changes with AMS prevalence, AMS severity, sleep quality and exercise condition in healthy young men.Methods: A prospective observational study was performed in 931 male young adults exposed to high altitude at 3,700 m(Lhasa) from low altitude(LA, 500 m). Blood pressure measurement and AMS symptom questionnaires were performed at LA and on day 1, 3, 5, and 7 of exposure to high altitude. Lake Louise criteria were used to diagnose AMS. Likewise, the Athens Insomnia Scale(AIS) and the Epworth Sleepiness Scale(ESS) were filled out at LA and on day 1, 3, and 7 of exposure to high altitude.Results: After acute exposure to 3,700 m, diastolic blood pressure(DBP) and mean arterial blood pressure(MABP) rose gradually and continually(P<0.05). Analysis showed a relationship with AMS for only MABP(P<0.05) but not for SBP and DBP(P>0.05). Poor sleeping quality was generally associated with higher SBP or DBP at high altitude, although inconsistent results were obtained at different time(P<0.05). SBP and Pulse BP increased noticeably after high-altitude exercise(P<0.05).Conclusions: Our data demonstrate notable blood pressure changes under exposure to different high-altitude conditions: 1) BP increased over time. 2) Higher BP generally accompanied poor sleeping quality and higher incidence of AMS. 3) SBP and Pulse BP were higher after high-altitude exercise. Therefore, we should put more effort into monitoring BP after exposure to high altitude in order to guard against excessive increases in BP. | Yang Liu Ji-Hang Zhang Xu-Bin Gao Xiao-Jing Wu Jie Yu Jian-Fei Chen Shi-Zhu Bian Xiao-Han Ding Lan Huang | 2014 | Journal of Medical Colleges of PLA(China)2014，29，2： | 6 |
| 2 | Smoking is associated with the incidence of AMS: A large-sample cohort study显示文摘Background: In recent years, the number of people visiting high altitudes has increased. After rapidly ascending to a high altitude, some of these individuals, who reside on plains or other areas of low altitude, have suffered from acute mountain sickness(AMS). Smoking interferes with the body's oxygen metabolism, but research about the relationship between smoking and AMS has yielded controversial results.Methods: We collected demographic data, conducted a smoking history and performed physical examinations on 2,000 potential study participants, at sea level. Blood pressure(BP) and pulse oxygen saturation(SpO2) were measured for only some of the patients due to time and manpower limitations. We ultimately recruited 520 smokers and 450 nonsmokers according to the inclusion and exclusion criteria of our study. Following acute high-altitude exposure, we examined their Lake Louise Symptom(LLS) scores, BP, HR and SpO2; however, cerebral blood flow(CBF) was measured for only some of the subjects due to limited time, manpower and equipment.Results: Both the incidence of AMS and Lake Louise Symptom(LLS) scores were lower in smokers than in nonsmokers. Comparing AMS-related symptoms between nonsmokers and smokers, the incidence and severity of headaches and the incidence of sleep difficulties were lower in smokers than in nonsmokers. The incidences of both cough and mental status change were higher in smokers than in nonsmokers; blood pressure, HR and cerebral blood flow velocity were lower in smokers than in nonsmokers.Conclusions: Our findings suggest that the incidence of AMS is lower in the smoking group, possibly related to a retardation of cerebral blood flow and a relief of AMS-related symptoms, such as headache. | Pan Song Ji-Hang Zhang Jun Qin Xu-Bin Gao Jie Yu Xu-Gang Tang Cai-Fa Tang Lan Huang | 2014 | Journal of Medical Colleges of PLA(China)2014，29，2： | 1 |
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