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		题名	作者	年代	出处	被引量
	1	Clinical significance of microRNA-130b in osteosarcoma and its role in cell growth and invasion显示文摘Objective: To investigate clinical signii cance of microRNA-130b(mi R-130b) in osteosarcoma and its role in cell growth and invasion. Methods: miR-130b expression was detected in 68 samples of surgically resected osteosarcoma and matched normal tumor-adjacent tissues by q RT-PCR. The expression of miR-130b was altered by corresponding vectors in osteosarcoma cells, and then Western blot was used to detect the expression of PPAR毭. Brd U cell proliferation and Transwell assays were performed to determine cell proliferation and invasion. Results: The expression of miR-130b in osteosarcoma tissues was signii cantly higher than that in normal tumor-adjacent tissues. Its expression in patients with metastasis was signii cantly higher than that in those without metastases. miR-130b expression in tumor tissues was signii cantly associated with tumor size, clinical stage and distant metastasis. And its expression was signii cantly correlated with overall survival and disease free survival. miR-130b overexpression obviously repressed the expression of PPAR毭, and resulted in signii cant increase of Saos-2 cell proliferation and invasion. On the contrast, repressing miR-130b expression with its inhibitor signii cantly increased PPAR毭 expression, and inhibited MG-63 cell proliferation and invasion. Conclusions: The high-expression of miR-130b is correlated with the adverse clinicopathological features and poor prognosis in osteosarcoma. miR-130b may regulate proliferation and invasion of osteosarcoma cells by targeting PPAR毭, suggesting miR-130b may play a key role in the progression of osteosarcoma.	Lie-Dao Yu Ri-Long Jin Peng-Cheng Gu Zhi-Heng Ling Xiang-Jin Lin Jing-Yu Du	2015	Asian Pacific Journal of Tropical Medicine2015，8，9：	3
	2	miR-720在乳腺癌中的表达水平显示文摘目的检测mi R-720在乳腺癌中的表达水平。方法应用Quantitative stem-loop RT–PCR检测55对石蜡包埋乳腺癌及相应癌旁组织、乳腺癌细胞与永生化乳腺上皮细胞中mi R-720的表达水平。结果 mi R-720在石蜡包埋乳腺癌组织和乳腺癌细胞中均呈低表达。结论 mi R-720在乳腺癌中表达水平降低,可能成为乳腺癌诊断的新的分子标志。	刘佳琴李国鸿逯晶易纯	2015	世界最新医学信息文摘2015，15，71：	0

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